Gene News and Research

Latest Gene News and Research

Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

The number of immune cells in and around kidney tumors, the amount of dead cancer tissue, and mutations to a tumor suppressor gene called PBRM1 form a biomarker signature that can predict — before treatment begins — how well patients with kidney cancer will respond to immunotherapy, according to new research directed by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

6 Apr 2023

Researchers discover and characterize a novel protein involved in tumor suppression mechanism

Understanding how cancer develops is critical for designing effective, personalized cancer therapies. Researchers have known for years that cancer begins with mutations in certain types of genes.

6 Apr 2023

Global antimicrobial resistance: socioeconomic factors play an underappreciated role in the spread

Researchers investigated the association between rates of antimicrobial resistance in animals and humans and environmental, socioeconomic, and anthropogenic indicators.

6 Apr 2023

Does higher caffeine and coffee intake impact colonic microbiota composition and diversity?

Researchers investigated the association between caffeine and the colonic microbiome.

6 Apr 2023

Study explores the species-specific use of ACE2 receptors by human and animal coronaviruses

Researchers assessed the ability of spike proteins from 24 animal or human coronaviruses to utilize angiotensin-converting enzyme 2.

5 Apr 2023

Omicron BA.5 variant demonstrates increased neuroinvasiveness and pathogenicity in mice

Researchers assessed the extent of SARS-CoV-2 Omicron VOC BA.5 sub-VOC infection-associated brain infection and death.

5 Apr 2023

Using brain organoids to test gene therapies for a rare disease in children

Brain tissue grown in a laboratory by University of Queensland researchers will be used to test a treatment for a rare disease in children and help unlock therapies for a range of neurological disorders.

5 Apr 2023

Complex assembly process involved in DNA virus replication revealed

In a twist on the question, "Which came first, the chicken or the egg?", scientists have long faced a similar question about how human adenovirus replicates: "Which comes first, assembly of the viral particle, or packaging of the viral genome?"

5 Apr 2023

IU study sheds new light on the development and treatment of rare form of muscular dystrophy

A study by Indiana University School of Medicine researchers sheds new light on the development and treatment of a rare form of muscular dystrophy.

5 Apr 2023

St. Jude computational biologists characterize the full spectrum of oncogenic fusions in pediatric cancer

The scientific foundation needed to work on curing a class of cancer-causing mutations is here, in the form of a tool from St. Jude Children's Research Hospital.

5 Apr 2023

Novel molecule may help overcome the devastating symptoms of Duchenne muscular dystrophy

In a new study published in The FASEB Journal, investigators demonstrated the potential of a molecule that may help overcome some of the devastating symptoms of Duchenne muscular dystrophy (DMD), the most common life-limiting congenital neuromuscular disorder.

5 Apr 2023

New method for lower respiratory tract infection diagnosis in critically ill children

Lower respiratory tract infection (LRTI), which includes conditions such as pneumonia, has long been the leading cause of death from communicable agents and a leading cause of death in children worldwide.

5 Apr 2023

Study sheds light on the mechanisms of brain plasticity induced by fluoxetine

A recent study, published in Neuropsychopharmacology, conducted by researchers from the University of Helsinki and the University of Eastern Finland, sheds light on the mechanisms of neural plasticity induced by the antidepressant fluoxetine.

5 Apr 2023

Biological underpinnings of a reproductive disorder caused by mutation of autism gene

A University of California, Riverside, study has identified the biological underpinnings of a reproductive disorder caused by the mutation of a gene.

5 Apr 2023

New treatment for fibrous dysplasia shows promising results in NIH clinical trial

A clinical trial at the National Institutes of Health found that a medication, denosumab, significantly reduced abnormal bone turnover in adults with fibrous dysplasia, a rare disease marked by weak and misshapen bones.

4 Apr 2023

CRISPR screens reveal genetic determinants of PARP inhibition in prostate cancer

Prostate cancer tumors harboring BRCA1/2 mutations are exceptionally sensitive to PARP inhibitors, while genomic alterations in other DNA damage response (DDR) genes are less responsive.

4 Apr 2023

Clinical trial may change the paradigm of care for patients with ALK-driven high-risk neuroblastoma

In a significant step for the treatment of neuroblastoma, an international group of researchers led by Children's Hospital of Philadelphia (CHOP), Winship Cancer Institute of Emory University and the New Approaches to Neuroblastoma Therapy (NANT) Consortium has shown that the targeted therapy lorlatinib is safe and effective in treating high-risk neuroblastoma.

4 Apr 2023

Gene News and Research

Latest Gene News and Research

Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

Researchers discover and characterize a novel protein involved in tumor suppression mechanism

Global antimicrobial resistance: socioeconomic factors play an underappreciated role in the spread

Does higher caffeine and coffee intake impact colonic microbiota composition and diversity?

Study explores the species-specific use of ACE2 receptors by human and animal coronaviruses

Omicron BA.5 variant demonstrates increased neuroinvasiveness and pathogenicity in mice

Using brain organoids to test gene therapies for a rare disease in children

Complex assembly process involved in DNA virus replication revealed

IU study sheds new light on the development and treatment of rare form of muscular dystrophy

St. Jude computational biologists characterize the full spectrum of oncogenic fusions in pediatric cancer

Novel molecule may help overcome the devastating symptoms of Duchenne muscular dystrophy

New method for lower respiratory tract infection diagnosis in critically ill children

Study sheds light on the mechanisms of brain plasticity induced by fluoxetine

Biological underpinnings of a reproductive disorder caused by mutation of autism gene

New treatment for fibrous dysplasia shows promising results in NIH clinical trial

CRISPR screens reveal genetic determinants of PARP inhibition in prostate cancer

Clinical trial may change the paradigm of care for patients with ALK-driven high-risk neuroblastoma

New software tool uses genetic data to improve cancer modeling technology

Research uncovers the root cause of adverse health effects from circadian rhythm disruption

Research provides new insights into the underlying disease mechanisms for polycystic kidney disease

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting