Gene

What are Genes?

Deoxyribonucleic acid (DNA) is the chemical information database that carries the complete set of instructions for the cell as to the nature of the proteins produced by it, its life span, maturity, function and death. Genes are the working subunits of DNA. Each gene contains a particular set of instructions, usually coding for a particular protein or for a particular function.

Gene History

Gene Concepts

Scientists reveal ability to reverse Huntington's disease-causing DNA repeat mutations in the lab

Neurodegenerative diseases, like Huntington's disease and myotonic dystrophy, are often referred to as DNA repeat diseases, named because of long repeated sequences in the DNA of patients. Increasing repeat expansion length in the affected tissues contribute to earlier age of disease onset and worsen the progression and severity of the disease over time.

27 Feb 2020

Increased numbers of bacterial cells could be associated with anti-microbial resistance

Scientists from the University of Surrey have identified mutations in a gene in an Escherichia coli (E. coli) model that could help explain a form of anti-microbial resistance (AMR) known as 'persistence'.

27 Feb 2020

Drug used for breast, renal cancers may provide survival benefit for patients with head and neck cancers

A targeted therapy drug used for breast and kidney cancers may also extend progression-free survival for patients with advanced head and neck cancer who are at high risk for recurrence after standard treatment.

27 Feb 2020

First human vaginal non-redundant gene catalog released

University of Maryland School of Medicine's Institute for Genome Sciences researchers have created the first catalog of genes that comprise the community of microbes, which inhabit the human vagina.

26 Feb 2020

Study reveals the effects of pre-surgical chemotherapy on breast cancer genome

Results from one of the first studies to determine the effects of pre-surgical, or neoadjuvant, chemotherapy on the breast cancer genome offer up two key insights.

26 Feb 2020

UC researchers uncover potential new treatment for patients with metastatic melanoma

Researchers at the University of Cincinnati have uncovered a potentially more beneficial treatment regimen for patients with metastatic melanoma.

26 Feb 2020

Study contributes to better understanding of rare KAT6A syndrome

A research team has described five new cases of a rare disease -known as KAT6A syndrome- of which there are only eighty dominant cases worldwide.

26 Feb 2020

New form of gene editing slows ALS progression in mice

With a new CRISPR gene-editing methodology, scientists from the University of Illinois at Urbana-Champaign inactivated one of the genes responsible for an inherited form of amyotrophic lateral sclerosis - a debilitating and fatal neurological disease for which there is no cure.

26 Feb 2020

Study identifies novel anti-aging targets

A recent study published in Nature has reported two conserved epigenetic regulators as novel anti-aging targets.

26 Feb 2020

Cellular metabolism plays key role in dictating the fate decision between pathogenic and regulatory T cells

Patients with autoimmune diseases like multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis have an imbalance between two types of immune system T cells.

26 Feb 2020

Gene-editing is more error-prone than thought, new findings suggest

The standard gene-editing tool, CRISPR-Cas9, frequently produces a type of DNA mutation that ordinary genetic analysis misses, claims new research published in the journal Proceedings of the National Academy of Sciences.

26 Feb 2020

Large non-protein coding gene regulates process vital to placental implantation in early pregnancy

Abnormal formation and growth of the placenta is considered an underlying cause of various pregnancy complications such as miscarriages, preeclampsia and fetal growth restriction.

25 Feb 2020

Genome research collaboration in Finland welcomes Janssen and Maze Therapeutics

FinnGen, a large-scale academic - industry, genome research collaboration in Finland now includes eleven industry partners with the addition of the Janssen Pharmaceutical Companies of Johnson & Johnson and Maze Therapeutics.

25 Feb 2020

Scientists discover new biological mechanism of insulin signaling

In a discovery that may further the understanding of diabetes and human longevity, scientists at Scripps Research have found a new biological mechanism of insulin signaling.

25 Feb 2020

Common challenges facing drug development and reimbursement for rare diseases

Approximately 90% of rare diseases still have no effective treatments, despite regulators implementing expedited approval pathways for these indications.

25 Feb 2020

A promising new oral therapy to speed up healing of broken bones

People with diabetes are at a higher risk of fracturing a bone than the general population. And if they do break one it also takes longer than normal to heal.

24 Feb 2020

Small molecules may open the door to new therapies for Duchenne muscular dystrophy

Researchers identified a group of small molecules that may open the door to developing new therapies for Duchenne muscular dystrophy, an as-yet-uncured disease that results in devastating muscle weakening and loss.

24 Feb 2020

DNA topological problems may cause lymphoma, study shows

Researchers from the Spanish National Cancer Research Centre, Madrid, and the Andalusian Molecular Biology and Regenerative Medicine Centre, Seville, published today a paper in Nature Communications that shows that DNA topological problems may cause endogenous DNA breaks that have a causal relationship with cancer.

24 Feb 2020

New way to chart human genome with CRISPR/nanopore sequencing technique

In search of new ways to sequence human genomes and read critical alterations in DNA, researchers at Johns Hopkins Medicine say they have successfully used the gene cutting tool CRISPR to make cuts in DNA around lengthy tumor genes, which can be used to collect sequence information.

24 Feb 2020

Inflammation caused by radiation can promote survival of triple-negative breast cancer cells

While radiation is successfully used to treat breast cancer by killing cancer cells, inflammation caused as a side-effect of radiation can have a contrary effect by promoting the survival of triple-negative breast cancer cells, according to research published online in the International Journal of Radiation Biology by Jennifer Sims-Mourtada, Ph.D., director of Translational Breast Cancer Research at ChristianaCare's Helen F. Graham Cancer Center & Research Institute.

24 Feb 2020

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Gene

Overview

Gene History

Gene Concepts

Latest Gene News and Research

Scientists reveal ability to reverse Huntington's disease-causing DNA repeat mutations in the lab

Increased numbers of bacterial cells could be associated with anti-microbial resistance

Drug used for breast, renal cancers may provide survival benefit for patients with head and neck cancers

First human vaginal non-redundant gene catalog released

Study reveals the effects of pre-surgical chemotherapy on breast cancer genome

UC researchers uncover potential new treatment for patients with metastatic melanoma

Study contributes to better understanding of rare KAT6A syndrome

New form of gene editing slows ALS progression in mice

Study identifies novel anti-aging targets

Cellular metabolism plays key role in dictating the fate decision between pathogenic and regulatory T cells

Gene-editing is more error-prone than thought, new findings suggest

Large non-protein coding gene regulates process vital to placental implantation in early pregnancy

Genome research collaboration in Finland welcomes Janssen and Maze Therapeutics

Scientists discover new biological mechanism of insulin signaling

Common challenges facing drug development and reimbursement for rare diseases

A promising new oral therapy to speed up healing of broken bones

Small molecules may open the door to new therapies for Duchenne muscular dystrophy

DNA topological problems may cause lymphoma, study shows

New way to chart human genome with CRISPR/nanopore sequencing technique

Inflammation caused by radiation can promote survival of triple-negative breast cancer cells

Isolating Single T-cells of Interest using an Optofluidic Platform

Microscopy in Neuroscience Research

Universal 'One-Size-Fits-All' Cancer Treatment

Gene

Overview

Latest Gene News and Research

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