Gene News and Research

Latest Gene News and Research

Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory

Replacing APOE4 with APOE2 in adult mice rapidly reshapes brain lipids and gene expression, even after development is complete. This switch, especially when targeted to astrocytes, reduces amyloid burden, dampens gliosis, and improves associative memory despite E2-like peripheral lipid risks.

12 Nov 2025

Researchers identify a protein vital to endothelial wound healing after surgery

Surgeons in the United States perform nearly 600,000 coronary artery stent procedures and bypass surgeries every year.

12 Nov 2025

Study clarifies how biliary atresia overlaps with multiple congenital syndromes

Biliary atresia (BA) represents one of the leading causes of pediatric liver failure, often requiring surgical intervention or transplantation in early infancy.

12 Nov 2025

LRIG1 could serve as important biomarker to distinguish between glioma types and grades

A new research paper was published in Oncotarget (Volume 16) on November 6, 2025, titled "LRIG1-3 in gliomas: LRIG1 protein expression decreased in higher grade gliomas."

12 Nov 2025

SwRI-developed single-use 3D-printed bioreactor harvests induced Pluripotent Stem Cells

Southwest Research Institute (SwRI) has demonstrated a new application for its cell-expansion bioreactor to advance tissue engineering and cell-based therapies for treatment of injuries and diseases.

12 Nov 2025

Study: Biological underpinnings of autism and ADHD may transcend traditional diagnostic boundaries

A new study published in Molecular Psychiatry reveals that the biological underpinnings of autism and ADHD may transcend traditional diagnostic boundaries.

12 Nov 2025

Common antibiotic can improve survival and neurological outcomes in CNS-TB

Researchers at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have demonstrated that doxycycline, a commonly available and inexpensive antibiotic, can improve survival rates and neurological outcomes in Central Nervous System Tuberculosis (CNS-TB) in a preclinical non-human study.

12 Nov 2025

Shift Bioscience publishes improved metric calibration framework for robust genetic perturbation modeling using AI Virtual Cells

Shift Bioscience (Shift), a biotechnology company uncovering the biology of cell rejuvenation to end the morbidity and mortality of aging, today announced the release of new research detailing an improved framework for evaluating benchmark metric calibration in virtual cell models. U

From Shift Bioscience 11 Nov 2025

Utah researchers uncover microglia as key regulators of anxiety in the brain

Anxiety disorders are some of the most common mental health conditions in America, affecting about one in five people nationwide.

11 Nov 2025

AI chat box helps investigate complex biology in English language

Using sophisticated RNA sequencing technology, biomedical researchers can measure the activity of our genes across millions of single cells, creating detailed maps of tissues, organs, and diseases.

11 Nov 2025

Northwestern scientists create new genetic risk score to improve prediction of arrhythmia

In a new Northwestern Medicine study, scientists have developed a more precise genetic risk score to determine whether a person is likely to develop arrhythmia, an irregular heartbeat that can lead to serious conditions such as atrial fibrillation (AFib) or sudden cardiac death.

11 Nov 2025

New precision therapies reshape the future of pancreatitis treatment

Pancreatitis remains a major global health burden, encompassing acute pancreatitis (AP), chronic pancreatitis (CP), and autoimmune pancreatitis (AIP).

11 Nov 2025

Targeting RNA splicing errors protects against tau-induced neurodegeneration

Alzheimer's Disease (AD), the leading cause of dementia, affects nearly 40 million individuals globally, resulting in a gradual loss of memory and independence. Despite extensive research over the past decades, no treatments have been found that can halt or reverse the progression of this devastating disease.

11 Nov 2025

Study uncovers new mechanism for chromosome congression during mitosis

A research team from The University of Osaka, in collaboration with the Massachusetts Institute of Technology, has uncovered a new molecular mechanism underlying chromosome alignment during cell division. The study demonstrates that two motor proteins, KIF18A and CENP-E, act cooperatively to ensure proper chromosome congression. Remarkably, simultaneous inhibition of these proteins selectively kills cancer cells, suggesting a promising therapeutic avenue.

10 Nov 2025

Micro-RNA in sperm proves vital for human embryogenesis

The sperm is not a passive supplier of genetic material to the egg. A study from Linköping University, Sweden, shows that certain molecules that come with the sperm, so-called micro-RNA, contribute to the development of the embryo several days after conception. The findings, published in the journal Nature Communications, may in the long term contribute to better diagnosis and treatment of involuntary childlessness.

10 Nov 2025

Study advances the possibility of age-based pancreatic cancer treatment

While some risk factors for cancer can be mitigated through lifestyle choices such as diet or exercise, aging is not one of them. In the case of pancreatic cancer, it also can limit treatment options if a patient is too frail to be safely treated with surgery or other alternatives.

10 Nov 2025

One-time CRISPR therapy safely lowers cholesterol and triglycerides in early trial

In a 15-patient, Phase 1 one, first-in-human trial, a one-time, CRISPR-Cas9 gene-editing therapy safely reduced LDL cholesterol and triglycerides in people with difficult-to-treat lipid disorders, according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025.

10 Nov 2025

Gene News and Research

Latest Gene News and Research

Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory

Researchers identify a protein vital to endothelial wound healing after surgery

Study clarifies how biliary atresia overlaps with multiple congenital syndromes

LRIG1 could serve as important biomarker to distinguish between glioma types and grades

SwRI-developed single-use 3D-printed bioreactor harvests induced Pluripotent Stem Cells

Study: Biological underpinnings of autism and ADHD may transcend traditional diagnostic boundaries

Common antibiotic can improve survival and neurological outcomes in CNS-TB

Shift Bioscience publishes improved metric calibration framework for robust genetic perturbation modeling using AI Virtual Cells

Utah researchers uncover microglia as key regulators of anxiety in the brain

AI chat box helps investigate complex biology in English language

Northwestern scientists create new genetic risk score to improve prediction of arrhythmia

New precision therapies reshape the future of pancreatitis treatment

Targeting RNA splicing errors protects against tau-induced neurodegeneration

Study uncovers new mechanism for chromosome congression during mitosis

Micro-RNA in sperm proves vital for human embryogenesis

Study advances the possibility of age-based pancreatic cancer treatment

One-time CRISPR therapy safely lowers cholesterol and triglycerides in early trial

Weill Cornell scientists discover early step in fat cell inflammation leading to diabetes

Uppsala researchers develop Trojan horse approach for medulloblastoma treatment

New diagnostic approach identifies dementia stages based on neurovascular and metabolic changes

eBook: Using iPSCs models for human disease research and drug discovery eBook

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting