Gene News and Research

Latest Gene News and Research

Accelerating rare disease diagnosis with Mondo

Coryssa Barnes, of Henderson, N.C., welcomed her first child, Ezra, in 2020. At four months old, he was unable to sit without support. As time went on, he failed to reach other developmental milestones, prompting his worried parents to consult several medical experts.

2 Mar 2026

ATP delivery fixes dysfunctional dopamine packaging in Parkinson's neurons

A new study shows how dysfunctional packaging of the neurotransmitter dopamine triggers toxic processes in neurons - and how this can be repaired with simple delivery of energy (ATP).

2 Mar 2026

Wisdom Bioscience establishes Scientific Advisory Board to advance oral cancer diagnostics and screening

Wisdom Bioscience, Inc., a biotechnology company pioneering non-invasive oral cancer diagnostics, today announced the formation of its Scientific Advisory Board (SAB) following the close of an initial funding round.

2 Mar 2026

Forecasting disease intensity through genomic risk

Approximately 60,000 Danes live with chronic inflammatory bowel disease. Some experience limited discomfort, while others go through a debilitating disease course involving surgery and a stoma. Add to this the fear of leaving home due to urgent toilet needs.

2 Mar 2026

The surprising neurological benefits of GLP-1s

For people with chronic migraine, taking glucagon-like peptide-1 receptor agonists, or GLP-1 drugs, for other conditions such as diabetes and weight loss, was associated with fewer emergency department visits and hospitalizations overall, and with less need for medications used to stop and prevent migraine attacks, according to a preliminary study released March 1, 2026, that will be presented at the American Academy of Neurology's 78th Annual Meeting taking place April 18-22, 2026, in Chicago and online.

2 Mar 2026

Study maps how NF-κB regulates gene expression in cells

To further the quantitative understanding of cellular decision making, Dr. Gregory Reeves and his team in the chemical engineering department have worked to interpret how a transcription factor dictates the alteration of gene expression in cells.

27 Feb 2026

NIH’s continued investment fuels TMJ pain research

Chronic pain is one of the most common health conditions worldwide. Back pain is the most frequently reported type, followed closely by head and face pain linked to the jaw joint, in the form of temporomandibular joint (TMJ) disorder.

27 Feb 2026

Expanded Seq-Scope method boosts gene-mapping resolution within tissues

In 2021, a technology developed at University of Michigan, called Seq-Scope, revolutionized the ability to map gene activity within intact tissue at microscopic resolution, enabling researchers to measure all expressed mRNA molecules and determine precisely where they are located within the tissue, using an Illumina sequencer machine.

27 Feb 2026

Engineered proteins track gene expression in living primate brains

Gene therapy has been successfully used to treat a number of diseases, including immune deficiencies, hereditary blindness, hemophilia and, recently, Huntington's disease, a fatal neurological disorder.

27 Feb 2026

New structural insights pave way for hantavirus vaccines

Hantaviruses, transmitted from rodents to people, have a death rate approaching 40%. They're found around the world, and because there are no approved vaccines or treatments, they're among the pathogens of highest concern for future pandemics.

27 Feb 2026

Genomic landscape and clinicopathologic significance of POLE mutant colorectal carcinoma

DNA polymerase epsilon catalytic subunit A (POLE) gene plays a crucial role in DNA repair and chromosomal replication.

27 Feb 2026

New pathway found connecting liver congestion to fibrosis and cancer

Researchers from The University of Osaka find that chronic liver congestion is linked to severe liver diseases through a specific signaling pathway in liver sinusoidal endothelial cells - key cells lining the liver's tiny blood vessels.

27 Feb 2026

Corneal nerve function declines with age in aniridia patients

Congenital aniridia is a rare disease caused, in most cases, by mutations in the PAX6 gene, which is essential for the development of ocular structures.

27 Feb 2026

Study reveals pancreatic cancer's early immune evasion tactics

A new study suggests that pancreatic cancer may start preparing to "hide" from the immune system long before the disease becomes full-blown cancer.

27 Feb 2026

New review explains how circular RNAs could unlock fat browning therapies

A Cell Death & Disease review synthesizes preclinical evidence that circular RNAs regulate adipose browning and metabolic pathways through microRNA interactions, protein binding, and organelle-linked stress mechanisms. It highlights their biomarker and therapeutic potential in obesity and type 2 diabetes while underscoring key translational challenges, including delivery specificity and human validation.

26 Feb 2026

Smoking triggers epigenetic damage linked to macular degeneration

Through a series of experiments supported by the National Institutes of Health, Johns Hopkins Medicine (JHM) researchers say they have advanced understanding of how smoking damages the eye and contributes to the development of age-related macular degeneration (AMD), the leading worldwide cause of visual impairment and blindness among people 50 and older.

26 Feb 2026

New method clarifies whether NOTCH1 variants cause congenital heart defects

One to two out of every 100 newborn babies are born with a Congenital Heart Defect (CHD), yet the exact cause remains unclear.

26 Feb 2026

Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80s

Researchers used single-nucleus RNA sequencing and chromatin accessibility profiling to map human hippocampal neurogenesis across adulthood, aging, and Alzheimer’s disease. They found that chromatin accessibility changes, more than gene expression alone, distinguish healthy aging, preclinical pathology, Alzheimer’s disease, and cognitive resilience in SuperAgers.

26 Feb 2026

Neanderthal DNA loss tied to ancient interbreeding dynamics

The human genome is a rich, complex record of migration, encounters, and inheritance written over thousands of millennia.

26 Feb 2026

Jumping DNA fragments found to destabilize cancer genome

A study published today in the journal Science reveals how jumping fragments of human DNA, a type of genetic parasite, destabilise the cancer genome. Unstable genomes are a fertile playground for cancer evolution, giving malignant cells more opportunities to grow, adapt and evade treatment.

26 Feb 2026