WARNING: Gastrointestinal hypomotility with severe complications:
Clozapine may cause slowing down or blockage of intestine function, causing reactions
such as constipation; nausea with or without vomiting; tenderness or swelling of the
abdomen, or bloating; gas/wind; foul-smelling breath; stomach pains/spasms; leakage
of diarrhoea or frequent and forceful bowel movements; bowel urges with no resulting
movements; weight loss due to lack of appetite; lower back pain; pain or pressure
in the rectum and bleeding from the rectum. These can lead to extremely severe outcomes.
Your doctor must monitor intestine function before prescribing and during your therapy
with Clopine. It is extremely important to immediately advise your doctor, coordinator,
pharmacist, or any other health professional, of any changes to your bowel movements.
Cases of myocarditis (heart inflammation) and cardiomyopathy (disease of heart muscles)
have been reported in patients on clozapine, some being very severe. Please advise
your doctor if you have, or previously had, any heart problems. Your doctor will also
monitor for this. If you feel any symptoms such as chest pain, please speak to your
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about CLOPINE.
It does not contain all the available information. It does not take the place of talking
to your doctor or pharmacist.
The information in this leaflet was last updated on the date listed on the final page.
More recent information on the medicine may be available. You should ensure that you
speak to your pharmacist or doctor to obtain the most up to date information on the
Those updates may contain important information about the medicine and its use of
which you should be aware.
All medicines have risks and benefits. Your doctor has weighed the risks of you taking
CLOPINE against the benefits they expect it will have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.
What CLOPINE is used for
CLOPINE is used in patients with schizophrenia for whom other antipsychotic medicines
have not worked or have caused severe side effects.
This medicine belongs to the group of medicines known as antipsychotics. This group
of medicines is mainly used in the treatment of schizophrenia. Schizophrenia is a
mental illness with disturbances in thinking, feelings and behaviour.
This medicine is thought to work by correcting the chemical imbalances in the brain
which may cause mental illness.
Ask your doctor if you have any questions about why this medicine has been prescribed
Your doctor may have prescribed it for another reason.
There is no evidence that this medicine is addictive.
This medicine is available only with a doctor's prescription.
There is not enough information to recommend the use of this medicine in children
under the age of 16 years.
Before you take CLOPINE
When you must not take it
Do not take CLOPINE if you have an allergy to:
any medicine containing clozapine
any of the ingredients listed at the end of this leaflet.
Some of the symptoms of an allergic reaction may include:
shortness of breath
wheezing or difficulty breathing
swelling of the face, lips, tongue or other parts of the body
rash, itching or hives on the skin
If you think that you are allergic to Clopine, ask your doctor for advice before taking
Do not take this medicine if you have a low white blood cell count, or if you have
previously had a low white blood cell count caused by a drug treatment (except if
it was following a treatment for cancer).
CLOPINE can cause agranulocytosis. This is a condition where the number of white blood
cells is reduced. These cells are needed to fight infections. If you have a low white
blood cell count or have had one in the past, you must not take CLOPINE.
Do not take CLOPINE if you are unable to have regular blood tests.
Before starting this medicine and during your therapy, checks will be required to
monitor the levels of various components in your blood. Your doctor will tell you
when these tests are needed.
Do not take this medicine if you have a problem with your intestines/bowel, including
any conditions in which the intestines do not work properly, or you experience severe
constipation or blockage (refer to the warning at the beginning of this document).
Do not take this medicine if you have or have had any of the following medical conditions:
any disease of the blood which causes a reduced number of red blood cells or platelets
bone marrow disorder
severe kidney disease
severe heart disease
problems with the circulatory (blood) or nervous system
symptoms of active liver disease such as jaundice (yellowing of the skin and eyes,
feeling sick, loss of appetite) , liver failure or any other severe liver diseasemyocarditis
(an inflammation of the heart muscle) or any other heart problems
uncontrolled epilepsy (fits or seizures)
problems with alcohol or drug abuse
CLOPINE must not be given to anyone who is unconscious or in a coma, or who has an
acute mental illness caused by alcohol or drugs.
Do not take this medicine after the expiry date printed on the pack or if the packaging
is torn or shows signs of tampering.
If it has expired or is damaged return it to your pharmacist for disposal.
If you are not sure whether you should start taking this medicine, talk to your doctor.
Before you start to take it
Tell your doctor if you have any allergies to any other medicines, foods, preservatives
Tell your doctor if you are pregnant or plan to become pregnant.
There is limited information on the safety of CLOPINE in pregnancy.
Your doctor will discuss the risks and benefits of taking this medicine during pregnancy.
Make sure you use a contraceptive to prevent pregnancy during treatment with CLOPINE.
Tell your doctor if you are breast- feeding or plan to breast-feed.
You should not breast feed during CLOPINE treatment. This medicine may pass into breast
milk and affect your baby.
Tell your doctor if you have or have had any of the following medical conditions:
heart disease or a family history of heart disease, including blood clots
chronic constipation or problems with your intestines/bowel. This needs to be treated
before you start taking CLOPINE. Your doctor must also monitor intestine function
while you are on CLOPINE.
difficulty passing urine or unable to pass urine.
joint-replacement, or other major surgery, or past major fractures or traumatic accidents
a job or pastime where you sit for long periods at a time, or if you travel sitting
down for long periods
any issues with walking around (called “mobility”)
any genetic conditions that cause abnormal blood clotting
serious lung disease, like pneumonia or obstructive pulmonary disease
liver or kidney problems
fits or epilepsy that is under control
diabetes or a family history of diabetes
glaucoma (raised pressure in the eye)
neuroleptic malignant syndrome, a reaction to some medicines with a sudden increase
in body temperature, sweating, fast heart beat, muscle stiffness and fluctuating blood
pressure, which may lead to coma
tardive dyskinesia, a reaction to some medicines with uncontrolled movements of the
tongue, face, mouth or jaw (such as puffing of the cheeks, puckering of the mouth
or chewing movements)
dementia, a condition in which there is a decline in all areas of mental ability
any other serious medical condition.
Your doctor may want to take special precautions if you have any of these conditions.
Tell your doctor if you will be in a hot environment or you do a lot of vigorous exercise.
CLOPINE may make you sweat less, causing your body to overheat.
Tell your doctor if you smoke and how much coffee you drink.
Smoking and caffeine can affect how CLOPINE affects your body. Sudden changes in
your usual smoking or coffee drinking habits can also change the effects of CLOPINE
and how much CLOPINE you need.
Tell your doctor if you are lactose intolerant.
This medicine contains lactose.
If you have not told your doctor or pharmacist about any of the above, tell them before
you start taking CLOPINE.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any
that you get without a prescription from your pharmacy, supermarket or health food
Some medicines and CLOPINE may interfere with each other. These include:
medicines which may decrease the number of blood cells produced by your body
strong pain killers such as morphine
antihistamines, medicines used to control and prevent symptoms of allergies such as
anticholinergic medicines, which are used to relieve stomach cramps, spasms and travel
medicines used to treat Parkinson's disease
medicines used to treat high blood pressure
medicines used to treat a fast or irregular heart beat such as digoxin
atropine, a medicine which may be used in some eye drops or cough preparations
adrenaline, a drug used in emergency situations
warfarin, a medicine used to prevent blood clots
medicines used for stomach ulcers and reflux oesophagitis such as cimetidine, pantoprazole,
lansoprazole and omeprazole
medicines used to treat bacterial infections such as erythromycin, clarithromycin,
azithromycin, norfloxacin, rifampicin, and ciprofloxacin
medicines used to treat epilepsy such as phenytoin, carbamazepine and valproic acid
other medicines for mental disorders such as schizophrenia, mood swings or depression
medicines to calm you and help you sleep such as benzodiazepines
medicines used to treat fungal and viral infections
St John's wort (Hypericum perforatum), a herbal remedy
birth-control tablets, or hormone-replacement therapy
These medicines may be affected by CLOPINE or may affect how well it works. You may
need to take different amounts of your medicine, or you may need to take different
medicines. Your doctor will advise you.
Your doctor and pharmacist may have more information on medicines to be careful with
or avoid while taking CLOPINE.
How to take CLOPINE
Follow all directions given to you by your doctor or pharmacist carefully.
They may differ from the information contained in this leaflet.
If you do not understand the instructions on the label, ask your doctor or pharmacist
Take CLOPINE exactly as prescribed by your doctor to help prevent unwanted side effects.
How much to take
Your dose of CLOPINE has been determined for you by your doctor. The dose will depend
on how you respond to the medicine, other medicines you are taking, and other medical
conditions that you may have. The dose may be altered from time to time.
When you first start taking CLOPINE, the usual dose is half of a 25 mg tablet (12.5
mg) taken once or twice on the first day, followed by one 25 mg tablet, once or twice
on the second day.
If this dose is well tolerated, then the dose may be slowly increased, usually to
between 200 mg and 450 mg each day. Once the maximum benefit is reached, the dose
can often be decreased to between 150 mg and 300 mg each day.
If you have heart, kidney or liver disease, epilepsy or you are elderly, your doctor
may start you on a lower dose and gradually increase the dose to prevent unwanted
Do not take more or less CLOPINE than your doctor has prescribed.
If you think the dose is too weak or too strong, talk to your doctor.
How to take it
The total daily amount of CLOPINE is usually divided into two doses. However, if your
total dose is 200 mg or less, your doctor may allow you to take the whole amount in
one dose, usually in the evening.
Swallow CLOPINE tablets with water or other liquid.
24 HOURS BEFORE THE FIRST USE:
1. Unscrew and remove the cap from the bottle.
2. Push the bottle adaptor into the top of the bottle. Once the adaptor is in place
it stays there.
3. Replace the cap and ensure it is tightened.
4. Before the first dose only, SHAKE THE BOTTLE for 90 seconds.
5. Note the expiry date on the product label in permanent marker as 90 days from the
date of opening.
6. Leave the bottle to stand for 24 hours to ensure the bubbles formed during shaking
IMMEDIATELY BEFORE DISPENSING DOSES:
1. Ensure the cap is tightened.
2. SHAKE THE BOTTLE for 10 seconds.
3. Remove the cap from the bottle.
4. Draw air into the oral dispenser (syringe) equivalent to the volume of the dose required.
5. Insert the oral dispenser into the opening of the bottle adaptor. Expel all the air
from the oral dispenser into the bottle.
6. Invert the bottle and slowly draw up the amount prescribed by your doctor
7. Turn the bottle upright and detach the oral dispenser from the bottle adaptor.
8. Invert the oral dispenser to prevent spillage. Swallow the contents of the oral dispenser.
9. Leave the bottle adaptor in place on the bottle.
10. Replace the bottle cap over the bottle adaptor after use.
11. Wash the oral dispenser with warm soapy water after each use. Then rinse well with
When to take it
Take your medicine at about the same time each day.
Taking it at the same time each day will have the best effect. It will also help you
remember when to take it.
It does not matter if you take this medicine before or after food.
How long to take it
Continue taking your medicine for as long as your doctor tells you.
This medicine helps to control your condition, but does not cure it. It is important
to keep taking your medicine even if you feel well.
If you forget to take it
If it is almost time for your next dose (within four hours), skip the dose you missed
and take your next dose when you are meant to.
Otherwise take it as soon as you remember, and then go back to taking CLOPINE as you
Do not take a double dose to make up for the dose that you missed.
This may increase the chance of you getting an unwanted side effect.
If you have missed taking CLOPINE for more than two days, do not start taking it again
before you contact your doctor.
To prevent unwanted side effects, your doctor will probably restart you on CLOPINE
at a lower dose and increase it gradually back to your normal dose.
If you are not sure what to do, ask your doctor or pharmacist.
If you have trouble remembering to take your medicine, ask your pharmacist for some
If you take too much (overdose)
Immediately telephone your doctor or the Poisons Information Centre (telephone 13
11 26) for advice, or go to Accident and Emergency at your nearest hospital, if you
think that you or anyone else may have taken too much CLOPINE. Do this even if there
are no signs of discomfort or poisoning.
You may need urgent medical attention.
The most common signs and symptoms of CLOPINE overdose include drowsiness, confusion
coma, light-headedness, shallow breathing or breathing more slowly, fast or irregular
heart beat and dribbling. Occasionally, fits have also been reported.
While you are using CLOPINE
Things you must do
Continue taking Clopine as long as your doctor tells you. If you have questions about
how long to take Clopine, talk to your doctor or your pharmacist.
You must have strict and regular blood tests while taking CLOPINE.
This medicine can cause agranulocytosis. This is a condition where the number of white
blood cells (which are necessary to fight infection in your body) may be reduced.
There is no way of knowing who is at risk of developing agranulocytosis.
Deaths have occurred in severe cases of agranulocytosis. However, with regular blood
tests, agranulocytosis can be detected early, and if CLOPINE is stopped as soon as
possible, the white blood cell numbers should return to normal.
After starting on CLOPINE, you must have a blood test at least once a week for the
first 18 weeks of treatment (this is when the risk of agranulocytosis is greatest),
thereafter at least every 4 weeks for as long as you are taking CLOPINE, and for one
month after stopping the medicine.
Your doctor will advise if blood tests are required more often. These tests will tell
the doctor if the white blood cell count is dropping.
There are some situations where you may need to have blood tests more often (eg twice
a week). Your doctor will talk to you about this.
If the number of your white blood cells falls below a critical level, CLOPINE must
be stopped immediately and you must never take any medicines containing clozapine
If you suffer from a high level of sugar in the blood (diabetes) your doctor may regularly
check your level of sugar in the blood.
Watch for important side effects:
Be mindful of any changes to your gastrointestinal function. Clozapine may cause slowing
down or blockage of intestine function, causing reactions such as constipation; nausea
with or without vomiting; tenderness or swelling of the abdomen, or bloating; gas/wind;
foul-smelling breath; stomach pains/spasms; leakage of diarrhoea or frequent and forceful
bowel movements; bowel urges with no resulting movements; weight loss due to lack
of appetite; lower back pain; pain or pressure in the rectum, and bleeding from the
rectum. These can lead to extremely severe outcomes. Your doctor must monitor intestine
function before prescribing and during your therapy with Clopine. It is extremely
important to immediately advise your doctor, coordinator, pharmacist, or any other
health professional, of any changes to your bowel movements..
If you develop a fast or irregular heart beat that is present even when you are resting,
accompanied by rapid breathing, shortness of breath, swelling of the feet or legs,
dizziness or light headedness, or chest pain, contact your doctor immediately.
These symptoms could be signs of myocarditis, an inflammation of the heart muscle,
or another heart condition. Your doctor may want to stop your CLOPINE and refer you
to a cardiologist for further tests.
If at any stage during treatment with CLOPINE you develop a sore throat, mouth ulcers,
fever, flu-like symptoms or other signs of infection, you must contact your doctor
This is necessary, as these symptoms may be an early sign of agranulocytosis, a problem
with the blood resulting in an increased risk of infections. Flu-like symptoms may
also be a sign of myocarditis.
Some patients develop fever in the first few weeks of taking CLOPINE. This is usually
harmless. However, you must be checked carefully to make sure you do not have an infection,
agranulocytosis, myocarditis or neuroleptic malignant syndrome, a reaction to some
medicines which can cause a sudden increase in body temperature.
If you notice any uncontrolled movements of the tongue, face, mouth or jaw, such as
puffing of the cheeks, puckering of the mouth or chewing movements, tell your doctor
These are symptoms of a condition called tardive dyskinesia which may develop in people
taking antipsychotic medicines. This condition is more likely to happen during long
term treatment, especially in older women. In very rare cases, it may be permanent.
However, if detected early, these symptoms are usually reversible.
If you are about to be started on any new medicines, remind your doctor and pharmacist
that you are taking CLOPINE.
Tell any other doctors, dentists, and pharmacists who treat you that you are taking
If you are going to have surgery tell the surgeon or anaesthetist that you are taking
It may affect other medicines used during surgery.
Make sure you use a contraceptive to prevent pregnancy during treatment with CLOPINE.
If you become pregnant while taking this medicine, tell your doctor immediately.
Your doctor can discuss with you the risks of taking it while you are pregnant. Some
women taking some antipsychotic medications have irregular or no periods. If you are
female and you have been affected in this way, your periods may return when your medication
is changed to Clopine.
If you suffer from severe stomach pain and/or constipation tell your doctor immediately.
If you develop severe stomach pain it
could be a sign of breakdown of part
of the intestine.
Be sure to keep all of your doctor's appointments so that your progress can be checked.
Your doctor may do some tests from time to time to make sure the medicine is working
and to prevent unwanted side effects.
Things you must not do
Do not take CLOPINE to treat any other complaints unless your doctor tells you to.
Do not give your medicine to anyone else even if they have the same condition as you.
Do not stop taking your medicine or lower the dosage without checking with your doctor.
If you stop taking it suddenly, your condition may worsen or you may experience headache,
nausea (feeling sick), vomiting or diarrhoea. Your doctor will gradually reduce the
amount you take each day before stopping the medicine completely.
Do not let yourself run out of CLOPINE over the weekend or on holidays.
Things to be careful of
Sudden unexplained death and heart attacks that may lead to death have been reported
Be careful driving or operating machinery until you know how CLOPINE affects you.
This medicine may cause tiredness, drowsiness, light-headedness, dizziness, fainting
or seizures (fits) in some people, especially at the start of treatment. Seizures,
drowsiness, fainting, muscle weakness may lead to falls. If you do have any of these
symptoms, do not drive, operate machinery or do anything else that could be dangerous.
If you feel light-headed, dizzy or faint when getting out of bed or standing up, get
Standing up slowly, especially when you get up from bed or chairs, will help your
body get used to the change in position and blood pressure. If this problem continues
or gets worse, talk to your doctor.
You should not drink alcohol while you are taking Clopine.
Clopine may enhance the effects of alcohol.
Be careful when taking antihistamines (medicines used for hayfever, allergies or colds),
sleeping tablets or tablets to relieve pain while taking this medicine.
If you take some medicines, drowsiness, dizziness or light-headedness may be worse.
CLOPINE may cause alteration in blood sugar and lipids. It may also cause weight gain.
Your doctor may monitor your weight, blood sugar and lipid levels.
CLOPINE can cause sleepiness, and remaining in bed for prolonged duration in combination
with weight gain may lead to the formation of blood clots in some patients.
Keep cool in hot weather and keep warm in cool weather.
This medicine may affect the way your body controls temperature, and it may prevent
sweating even in very hot weather. Exercise, hot baths or saunas may make you feel
dizzy or faint while you are taking this medicine.
Tell your doctor if you stop smoking or change the number of caffeine-containing drinks
that you have in one day.
These changes can affect the levels of this medicine in your blood.
Tell your doctor if you are going to be hospitalised or on bed rest for a long period
Being immobile for long periods of time can increase your risk of developing blood
clots while taking CLOPINE.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are taking CLOPINE.
This medicine helps most people with schizophrenia, but it may have unwanted side
effects in a few people. All medicines have side effects. Sometimes these are serious,
most of the time they are not. You may need medical treatment if you get some of the
If you are over 65 years old, you may have an increased chance of getting side effects.
Do not be alarmed by the following lists of side effects. You may not experience
any of them.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor or pharmacist if you notice any of the following:
tiredness, drowsiness or fatigue
dizziness, fainting, light-headedness
too much saliva
difficulty in swallowing
swelling of the glands in the cheeks
constipation (if it seems to be getting worse, check with your doctor immediately)
abdominal discomfort, heartburn or dyspepsia
changes in sexual function
painful menstrual periods
problems in passing or holding urine, dark urine, excessive urination, nocturnal bedwetting
skin reactions or change in the colour of the skin
agitation, confusion, disorientation, vivid dreams
increased or decreased sweating
rash, purplish-red spots usually associated with fever or itching
"butterfly" rash, joint pain, muscle pain, fever and fatigue
uncontrolled bending of the body to one side
repetitive and ritualised behaviour (obsessive compulsive symptoms)
for males, dry orgasm (retrograde ejaculation) where very little or no semen is ejaculated
as it enters the bladder instead. Urine will appear cloudy after an orgasm
a strong urge to move the legs (restless legs syndrome) with an unpleasant feeling
in the legs
If any of the following happen, tell your doctor immediately or go to Accident & Emergency
at your nearest hospital:
signs of an allergic reaction such as itching, skin rash, hives, swelling of the face,
lips or tongue, difficulty in swallowing or breathing
slowing down or blockage of intestine function, causing reactions such as constipation;
nausea with or without vomiting; tenderness or swelling of the abdomen, or bloating;
gas/wind; foul-smelling breath; stomach pains/spasms; leakage of diarrhoea or frequent
and forceful bowel movements; bowel urges with no resulting movements; weight loss
due to lack of appetite; lower back pain; pain or pressure in the rectum and bleeding
from the rectum
fainting or loss of consciousness
falls due to seizure, drowsiness, fainting, muscle weakness
sore throat, mouth ulcers, fever, any "flu-like" symptoms such as swollen glands or
other signs of infection
a sudden increase in body temperature, sweating, fast heart beat and muscle stiffness
which may be symptoms of neuroleptic malignant syndrome
fast or irregular heart beat even when you are resting, accompanied by rapid breathing,
shortness of breath, swelling of the feet or legs, dizziness or light headedness,
or chest pain
signs that blood clots may have formed, such as sudden severe headache, sudden loss
of coordination, blurred vision or sudden loss of vision, slurred speech, numbness
in an arm or leg, chest pain or shortness of breath.
uncontrolled movements of the tongue, jaw, face and mouth (such as puffing at the
cheeks, chewing movements, puckering of the mouth, lipsmacking, grimacing and rapid
eye blinking). These are symptoms of a very rare condition called tardive dyskinesia.
abnormal movements, inability to start moving, inability to stay still, inner feeling
of restlessness, stiff limbs, trembling hands
signs of pneumonia or lower respiratory tract infection such as difficulty breathing,
coughing, and chest pain
signs of sepsis such as shivering, fever, rapid breathing and heart rate, a change
in your mental state sus confusion or disorientation
seizures or fits
jaundice, yellowing of the skin and/or eyes
urinary problems - difficulty passing urine (water) or blood in the urine; loss of
signs of loss of blood sugar control such as excessive thirst, passing large amounts
of urine, dry mouth and skin
muscle spasms associated with fever and/or red-brown urine
loss of co-ordination, shaking or tremor, feeling unable to sit still, rigidity or
muscle stiffness/spasms/weakness or pain
persistent painful erection or prolonged erection
unusual bruising or bleeding
cough, hiccups, rapid breathing,chest pain which can be associated with abdomen pain
pauses in breathing or periods of shallow breathing during sleep.
The above list includes serious side effects which may require medical attention.
Tell your doctor or pharmacist if you notice anything else that is making you unwell.
Other side effects not listed above may also occur in some people.
Some side effects can only be found when your doctor does tests to check your progress.
These tests could show a reduction in white blood cells, red blood cells or changes
in blood platelet levels. These tests could also show a change in liver enzymes, blood
sugar and lipid levels.
After using CLOPINE
Keep your medicine in the original packaging until it is time to take it.
Tablets and Suspension:
Keep your tablets in a cool dry place where the temperature stays below 30°C. Protect
Store the CLOPINE Suspension below 25°C. Recap the bottle tightly following each use.
Discard the bottle 90 days after it has been opened.
Do not store CLOPINE tablets or suspension or any other medicine in the bathroom or
near a sink. Do not leave it on a window sill or in the car.
Heat and dampness can destroy some medicines.
Keep it where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place
to store medicines.
If your doctor tells you to stop taking CLOPINE or the medicine has passed its expiry
date, ask your pharmacist what to do with any medicine that is left over.
CLOPINE Suspension expires 90 days after first opening the bottle.
Remember that you must still have your blood tested for a month after stopping this
What it looks like
CLOPINE 25 are small, round, yellow tablets with "25" embossed over a breakline on
one face, the other side is plain.
CLOPINE 50 are small, round, yellow tablets with "50" embossed over a breakline on
one face, the other side is plain.
CLOPINE 100 are small, round, yellow tablets with "100" embossed over a breakline
on one face, the other side is plain.
CLOPINE 200 are oval shaped yellow tablets with "200" embossed on one side and a breakline
on the other side.
CLOPINE Suspension is a yellow mixture called a suspension in a glass amber bottle
containing 100 mLs.
CLOPINE 25, CLOPINE 50, CLOPINE 100 and CLOPINE 200 come in blister packs or bottles
of 100 tablets.
CLOPINE Suspension comes in a 125 mL bottle containing 100 mLs of the suspension.
The quantity provided to you by the pharmacy will be determined by your doctor.
CLOPINE 25 tablets contain 25 mg of clozapine. CLOPINE 50 tablets contain 50 mg of
clozapine. CLOPINE 100 tablets contain 100 mg of clozapine. CLOPINE 200 tablets contain
200 mg of clozapine.
CLOPINE tablets also contain:
sodium starch glycollate
Each 1 ml of CLOPINE Suspension contains 50 mg of clozapine.
CLOPINE suspension also contains:
sorbitol solution (70 per cent)
monobasic sodium phosphate dihydrate
sodium methyl hydroxybenzoate
sodium propyl hydroxybenzoate,
This medicine does not contain sucrose, gluten, tartrazine or any other azo dyes.
Pfizer Australia Pty Ltd
Toll Free Number: 1800 675 229
CLOPINE is a registered trade mark of Douglas Pharmaceuticals Limited used under licence.
CLOPINE 25 in blister packs
AUST R 67947
CLOPINE 25 in bottles
AUST R 93972
CLOPINE 50 in blister packs
AUST R 95557
CLOPINE 50 in bottles
AUST R 95559
CLOPINE 100 in blister packs
AUST R 67948
CLOPINE 100 in bottles
AUST R 93973
CLOPINE 200 in blister packs
AUST R 95560
CLOPINE 200 in bottles
AUST R 95561
AUST R 142239 (not supplied)
This leaflet was updated in