Atomic force microscopy (AFM) is a high-resolution surface analysis technique that allows for 3D topographic imaging at the nanoscale and multiparametric characterization of the mechanical properties of soft matter, materials, as well as biological samples.
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When it comes to analyzing living cells, challenging biological samples and thick, multilayer tissue samples require purposefully designed instrumentation. BioAFMs are ideal when it comes to these samples, as they allow for measurements under near-physiological or controlled environmental conditions.
BioAFMs can also be seamlessly integrated with advanced optical microscopy to deliver complementary datasets and correlated measurements, offering novel insights into molecular mechanisms and paving the way for new and exciting research applications.
This eBook is a valuable tool for both seasoned AFM users and those still unfamiliar with the technique but interested in learning more about how it can expand their current research capabilities. Readers can expect to find an overview of BioAFM technology, practical tips on getting the most out of the technique, and other key information.
Key topics covered:
- The working principle of BioAFM, including the latest advanced features and imaging modes
- How to choose cantilevers for specific biological applications
- Enhancing analysis capabilities through correlative microscopy and the integration of AFM with advanced optical techniques.
A dive into some case studies demonstrating the application of BioAFM in life science research, including the investigation of DNA origami, cellular and molecular dynamics, and microrheological in living cells, as well as AFM-based single-molecule force spectroscopy
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About Bruker Nano Surfaces and Metrology
Bruker’s suite of fluorescence microscopy systems provides a full range of solutions for life science researchers. Their multiphoton imaging systems provide the imaging depth, speed and resolution required for intravital imaging applications, and their confocal systems enable cell biologists to study function and structure using live-cell imaging at speeds and durations previously not possible. Bruker’s super-resolution microscopes are setting new standards with quantitative single molecule localization that allows for the direct investigation of the molecular positions and distribution of proteins within the cellular environment. And their Luxendo light-sheet microscopes, are revolutionizing long-term studies in developmental biology and investigation of dynamic processes in cell culture and small animal models.
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