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New machine learning algorithm finds a gene signature characteristic of tumors

How do cancer cells differ from healthy cells? A new machine learning algorithm called "ikarus" knows the answer, reports a team led by MDC bioinformatician Altuna Akalin in the journal Genome Biology. The AI program has found a gene signature characteristic of tumors.

10 Jun 2022

New molecule kills a broad spectrum of hard-to-treat cancers

A new molecule synthesized by a University of Texas at Dallas researcher kills a broad spectrum of hard-to-treat cancers, including triple-negative breast cancer, by exploiting a weakness in cells not previously targeted by other drugs.

10 Jun 2022

Proteomic analysis of 2002 tumors reveals 11 distinct pan-cancer molecular subtypes

A new study that analyzed protein levels in 2,002 primary tumors from 14 tissue-based cancer types identified 11 distinct molecular subtypes, providing systematic knowledge that greatly expands a searchable online database that has become a go-to platform for cancer data analysis by users worldwide.

10 Jun 2022

Stress protein in fibroblasts appears to be an attractive cancer drug target

A stress protein that is overactive in many types of tumor cells also has a key role in tumor-supporting cells called fibroblasts, and may be a good target for future cancer treatments, suggests a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

10 Jun 2022

Naturally-produced antibodies in mothers may enhance infants' immunity against bacterial pathogens

Researchers have known for some time that maternal breast milk provides critical nutrients for newborns, and antibodies from mothers vaccinated against a specific disease-causing bacterium or virus can be transferred via breast milk to babies.

10 Jun 2022

Deciphering the structure of nuclear pore complex piece by piece

Whatever you are doing, whether it is driving a car, going for a jog, or even at your laziest, eating chips and watching TV on the couch, there is an entire suite of molecular machinery inside each of your cells hard at work.

10 Jun 2022

Creating CAR T cells without an immune brake

T cells are usually very good at eliminating diseased cells. But they seem to fail when it comes to tumor cells.

10 Jun 2022

McMaster scientists develop new rapid test to detect infections in farm animals

Researchers at McMaster University have developed a new form of rapid test to detect infections in farm animals, responding to the rising threat of dangerous outbreaks.

10 Jun 2022

Brain area communication changes over much faster timescales than previously thought

Understanding how brain areas communicate is one of the oldest questions in neuroscience. Researchers at the Sainsbury Wellcome Centre at UCL used causal techniques to uncover how two neocortical areas in the brain communicate with one another and found that their influence on each other changes over much faster-timescales than previously thought.

10 Jun 2022

First-in-class, anti-cancer mitochondrial drug found to be effective against most carcinoma cell lines

A study of the lead agent (CPI-613) in a class of anticancer drugs undergoing Food and Drug Administration (FDA) approved clinical trials reveals that CPI-613 is effective against most carcinoma cell lines, and, used in combination, could have efficacy against reducing some tumors.

9 Jun 2022

New analysis sheds light on diversity and ecological footprint of marine RNA viruses

Community- and "species"-level analysis on Global Ocean RNA sequences sampled from waters worldwide has shed light on the poorly understood diversity and ecological footprint of marine RNA viruses, according to a new report.

9 Jun 2022

New, tiny probe for long-lasting and minimally invasive interfacing with neural circuits

Researchers at the University of California San Diego and the Salk Institute for Biological Studies have developed a tiny neural probe that can be implanted for longer time periods to record and stimulate neural activity, while minimizing injury to the surrounding tissue.

9 Jun 2022

Genomic analysis provides a deeper understanding of DCIS biology

A new study led by the global Cancer Grand Challenges PRECISION team, including researchers from The University of Texas MD Anderson Cancer Center, shifts the long-held belief that all invasive breast cancers following ductal carcinoma in situ (DCIS) arise from the original DCIS lesion.

9 Jun 2022

Aspirin changes the way colorectal cancer cells evolve over time, study reveals

Cancer starts when cells start dividing uncontrollably. Scientists have known that taking aspirin can help protect against the development of colorectal cancer – cancer afflicting the colon or rectum – but the exact reason aspirin has this effect has been mostly a mystery.

9 Jun 2022

Life Science News

New machine learning algorithm finds a gene signature characteristic of tumors

New molecule kills a broad spectrum of hard-to-treat cancers

Proteomic analysis of 2002 tumors reveals 11 distinct pan-cancer molecular subtypes

Stress protein in fibroblasts appears to be an attractive cancer drug target

Naturally-produced antibodies in mothers may enhance infants' immunity against bacterial pathogens

Deciphering the structure of nuclear pore complex piece by piece

Creating CAR T cells without an immune brake

McMaster scientists develop new rapid test to detect infections in farm animals

Brain area communication changes over much faster timescales than previously thought

First-in-class, anti-cancer mitochondrial drug found to be effective against most carcinoma cell lines

New analysis sheds light on diversity and ecological footprint of marine RNA viruses

New, tiny probe for long-lasting and minimally invasive interfacing with neural circuits

Genomic analysis provides a deeper understanding of DCIS biology

Aspirin changes the way colorectal cancer cells evolve over time, study reveals

Cryo-EM helps scientists to decipher the structure of a key part of RNA degradation machinery

Infiltrating gliomas are shaped by genetic evolution and microenvironment, finds study

Researchers reveal important factor behind cancer therapy resistance and a way to counter it

Artificial intelligence-based computational program predicts the 3D structure of rotavirus spike protein

Research reveals how highly proliferative leukemia cells turn into normal harmless ones

Researchers create first comprehensive functional map of genes expressed in human cells

The Proteoform Puzzle: Unlocking the Next Frontier

Synthetic Biology and the Pursuit of Living Diagnostics

Modular, Scalable, Intelligent: How n6 Is Rethinking NGS Library Prep

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