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Safety, reactogenicity, and immunogenicity of the BNT and half-m1273 mRNA COVID-19 vaccines given as a fourth dose booster

Researchers evaluated the immunogenicity of Pfizer’s BNT162b2 and Moderna’s mRNA-1273 vaccines offered as the fourth dose against SARS-CoV-2.

12 Apr 2022

COVID-19 vaccination during pregnancy not associated with any observable birth defects on ultrasound

In our latest interview, News Medical speaks to Dr. Rachel Ruderman about her current research, which reveals no detectable link on ultrasound scans between COVID-19 vaccination and birth defects.

12 Apr 2022

Differences in symptoms and risk of hospitalization following infection with Omicron or Delta SARS-CoV-2 variants among vaccinated people

A recent study assessed the prevalence of SARS-CoV-2 symptoms and the risk of hospitalization in vaccinated individuals infected with SARS-CoV-2 Omicron and Delta variants.

12 Apr 2022

SARS-CoV-2 mutations change proteasome processing to alter CD8+ T cell responses

Researchers identified mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleoproteins (NP) epitope flanking regions and their potential effects on CD8+ T cell activation.

12 Apr 2022

Unique heightened aggregation of SARS-CoV-2 Delta variant spike pseudotyped particles

A recent study illustrated the enhanced distinct clustering of pseudotyped particles (PPs) expressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant.

12 Apr 2022

NVX-CoV2373 vaccine found to induce functional SARS-CoV-2-specific T cell responses

In a recent study researchers evaluated the T cell responses elicited by full-length severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein vaccine NVX-CoV2373.

12 Apr 2022

Scientists find critical role for Hippo signaling pathway in COVID-19 pathogenesis

A recent article posted to the bioRxiv* preprint server illustrated that the activation of the Hippo signaling pathway upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection aids the host antiviral response.

11 Apr 2022

Drug used to treat lung cancer could help improve survival rates for bladder cancer patients

Scientists from the University of Sheffield have discovered a drug already used to treat lung cancer could help to improve survival rates for bladder cancer patients.

11 Apr 2022

Therapies for LGL leukemia should target the immune system, not only cancer cells

An international study coordinated by a University of Helsinki research group demonstrates that the body's immune system attacks itself in a rare type of blood cancer.

11 Apr 2022

Inflammation weakens odor signals and may be responsible for COVID19 loss of smell

Anosmia, the loss of smell, is a frequent and often long-term symptom associated with COVID-19 that can severely burden a person's quality of life, making it extremely difficult to taste foods, detect airborne hazards in the environment and carry out other functions dependent on the sense.

11 Apr 2022

Study identifies several therapeutically effective drugs for bladder cancer

Hundreds of chemical compounds were screened on cell cultures representing different stages and subtypes of bladder cancer and several promising agents with inhibitory (growth-inhibiting) effects were identified.

11 Apr 2022

Cryo-electron microscopy shows how Omicron BA.2 structure differs from BA.1 substantially

Researchers used cryogenic electron microscopy (cryo-EM) to determine the structure of the spike (S) protein of BA.2 sub-variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern (VOC) and compared them with previously determined S structures of Omicron's BA.1 sub-variant.

11 Apr 2022

Drugs targeting DNA damage response pathway show therapeutic potential against advanced solid tumors

Results from early-stage clinical trials show two drugs that target the DNA damage response (DDR) pathway in cancers - ATR inhibitor elimusertib and PARP inhibitor AZD5305 - are safe and clinically beneficial in treating patients with advanced solid tumors.

11 Apr 2022

Patients with allergic disorders have greater risk of high blood pressure and coronary heart disease

Data from the National Health Interview Survey demonstrated adults with a history of allergic disorders have an increased risk of high blood pressure and coronary heart disease, with the highest risk seen in Black male adults.

11 Apr 2022

The relationship between household type, COVID-19 and mental health

Researchers demonstrated the relationship between the built environment with a common element and coronavirus disease 2019 (COVID-19) transmission and mental health conditions.

11 Apr 2022

Study finds molecular features responsible for the development of metastatic breast cancer

Susana Garcia-Recio, PhD, a research associate in the lab of Charles M. Perou, PhD, at UNC Lineberger Comprehensive Cancer Center, will present findings that identified molecular features responsible for the development and progression of metastatic breast cancer at the 2022 American Association for Cancer Research annual meeting. (Presentation: Abstract LB176/4, Tuesday, April 12, 3:20 p.m. ET, Room 217-219, Ernest N. Morial Convention Center in New Orleans.)

11 Apr 2022

Discovery of key regulator of body weight could lead to new treatments for metabolic disorders

Yale scientists uncover key regulator of body weight. Yale scientists have discovered that a protein known as augmentor-alpha regulates body weight in mice, an insight that could lead to new treatments for metabolic disorders.

11 Apr 2022

UMass Amherst-based COVID-19 Forecast Hub generates accurate predictions of pandemic deaths

The University of Massachusetts Amherst-based U.S. COVID-19 Forecast Hub, a collaborative research consortium, has generated the most consistently accurate predictions of pandemic deaths at the state and national level, according to a paper published April 8 in the Proceedings of the National Academies of Sciences.

11 Apr 2022

Sex-specific guidelines needed for treating obesity, hypertension and diabetes in women

Academic researchers are calling for new healthcare guidelines for treating obesity, hypertension and diabetes in women. Currently, there are no sex-specific guidelines for treating or preventing these health conditions, potentially limiting the medical care available to women.

11 Apr 2022

Alternative anti-HIV strategy generates promising results in a phase I clinical trial

vaccines against the virus, but unfortunately, HIV has numerous defense mechanisms that prevent a person's immune system from mounting an effective response following HIV vaccination.

11 Apr 2022

Medical News

Safety, reactogenicity, and immunogenicity of the BNT and half-m1273 mRNA COVID-19 vaccines given as a fourth dose booster

COVID-19 vaccination during pregnancy not associated with any observable birth defects on ultrasound

Differences in symptoms and risk of hospitalization following infection with Omicron or Delta SARS-CoV-2 variants among vaccinated people

SARS-CoV-2 mutations change proteasome processing to alter CD8+ T cell responses

Unique heightened aggregation of SARS-CoV-2 Delta variant spike pseudotyped particles

NVX-CoV2373 vaccine found to induce functional SARS-CoV-2-specific T cell responses

Scientists find critical role for Hippo signaling pathway in COVID-19 pathogenesis

Drug used to treat lung cancer could help improve survival rates for bladder cancer patients

Therapies for LGL leukemia should target the immune system, not only cancer cells

Inflammation weakens odor signals and may be responsible for COVID19 loss of smell

Study identifies several therapeutically effective drugs for bladder cancer

Cryo-electron microscopy shows how Omicron BA.2 structure differs from BA.1 substantially

Drugs targeting DNA damage response pathway show therapeutic potential against advanced solid tumors

Patients with allergic disorders have greater risk of high blood pressure and coronary heart disease

The relationship between household type, COVID-19 and mental health

Study finds molecular features responsible for the development of metastatic breast cancer

Discovery of key regulator of body weight could lead to new treatments for metabolic disorders

UMass Amherst-based COVID-19 Forecast Hub generates accurate predictions of pandemic deaths

Sex-specific guidelines needed for treating obesity, hypertension and diabetes in women

Alternative anti-HIV strategy generates promising results in a phase I clinical trial

How Programmable Nanobiology Could Drive the Fifth Industrial Revolution

Dr. Anthony Grice

Building quality into drug development for safer, faster medicines

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