Randox unveils innovative test for risk assessment of cardiovascular disease

Global diagnostics company Randox Laboratories has unveiled an innovative new test for the risk assessment of cardiovascular disease at this year's AACC Clinical Lab Expo in Anaheim, California.

The test detects and measures the cardiac biomarker sPLA2-IIA. When raised, sPLA2-IIA is an independent indicator of primary and secondary cardiovascular risk.

The release of the new automated sPLA2-IIA assay from Randox adds to the company's extensive cardiac and lipid testing panel, that are all designed for use on biochemistry platforms.

Susan Hammond, Randox Product Specialist, commented:

By 2030, it is estimated that almost 23.6 million people globally will die from CVD, with heart disease and stroke projected to remain the leading causes of death. This confirms that early diagnosis is an essential step in reducing the number of individuals affected. The continued investment and addition of early biomarkers that add clinical utility in cardiac risk testing is key to refining clinical assessment, and ultimately the treatment plan required.

sPLA2-llA, a member of the secretory phospholipase A2 family, offers clinical utility as an inflammatory biomarker specifically in the diagnosis of CVD risk. As the prototypic member of the group II sPLA2 subfamily, it is known as "inflammatory sPLA2".

Susan Hammond continued:

sPLA2 -llA hydrolyses phospholipids from membranes, native lipoproteins and oxidized protein. As it is not bound to Apolipoprotein B its impact is more significant. Hydrolysis produces biolipid mediators lyso phospholipids and fatty acids along with Arachidonic acid which then accelerates inflammatory mediators. Due to increases in lipid and inflammatory mediators, increased cholesterol rich foam cells form- adding to plaque formation. sPLA2-IIA reduces biomarkers such as HDL-C capacity to mediate cellular cholesterol efflux from these lipid-loaded macrophages."

Key Benefits of Randox sPLA2-llA

  • A niche product from Randox meaning that Randox are one of the only manufacturers to provide the sPLA2-llA mass test in an automated biochemistry format.
  • Applications available detailing instrument-specific settings for the convenient use of the Randox sPLA2-llA assay on a wide range of clinical chemistry analysers.
  • Liquid ready-to-use reagents for convenience and ease-of-use.
  • Latex enhanced immunoturbidimetric method delivering high performance.
  • Dedicated controls and calibrators available offering a complete testing package.
  • Automated assay which removes the inconvenience and time consumption associated with traditional ELISA based testing.


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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