Antimicrobial Drug News and Research

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Antimicrobials are substance that kills microorganisms such as bacteria or mold, or stops them from growing and causing disease.

Nasal vaccine for smallpox protects animals against 77 times the potentially lethal dose of smallpox

Scientists at NanoBio Corporation and the University of Michigan have demonstrated their nasally delivered vaccinia vaccine can protect animals against 77 times the potentially lethal dose of smallpox, and without the safety risks of current vaccines for smallpox.

27 Feb 2008

Scientists identify proteins that help bacteria put up a fight

Scientists have identified the role of two proteins that contribute to disease-causing bacteria cells' versatility in resisting certain classes of antibiotics.

27 Feb 2008

Questions over use of antibiotics in 'end of life' care

Antibiotics appear to be frequently prescribed to individuals with advanced dementia in nursing homes, especially in the two weeks before death, according to a report in the February 25 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

26 Feb 2008

Newly discovered ERK pathway proteins related to CagA induced disease

Cytotoxin-associated gene A protein (CagA) from type I H.pylori has been proved by epidemiological and experimental studies to be closely associated with the H.pylori induced gastric diseases, especially gastric cancer.

25 Feb 2008

Researchers examine animal antibiotic resistance, possible human link

It's bad enough when pathogenic bacteria work their way into the animal food supply.

20 Feb 2008

Mathematical approach to tackle dual-resistant hospital infections

A mathematical model that looks at different strategies for curbing hospital-acquired infections suggests that antimicrobial cycling and patient isolation may be effective approaches when patients are harboring dual-resistant bacteria.

17 Feb 2008

Researchers find new U.S. trend in antibiotic resistance

A research team from The University of Texas Health Science Center at San Antonio, examining bacterial isolates obtained in hospital and non-hospital clinical settings between 2000 and 2006, has identified drug-resistant strains of E. coli and Klebsiella bacteria in more than 50 blood, urine and respiratory samples.

11 Feb 2008

Unique fungal collection could hold key to future antibiotics

Scientists at Royal Holloway, University of London have joined forces with CABI to establish a facility to screen for potential new antibiotics.

23 Jan 2008

New compounds for treating tuberculosis and malaria

University of Navarra PhD in chemistry researcher, Esther Vicente, has discovered new compounds active for treating tuberculosis and malaria.

23 Jan 2008

Studies highlight MRSA evolution and resilience

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are caused primarily by a single strain USA300 of an evolving bacterium that has spread with "extraordinary transmissibility" throughout the United States during the past five years, according to a new study led by National Institutes of Health (NIH) scientists.

22 Jan 2008

Brits get to grips with superbugs

The British government, as part of it's fight against 'superbugs' such as methicillin-resistant Staphylococcus aureu (MRSA) and Clostridium difficile, has promised every hospital the funds to recruit four specialist nurses to help curb the infections.

10 Jan 2008

Urinary tract infections from the catheter - most common hospital-acquired infection

One in four Americans in the hospital right now has a urinary catheter. One percent of them will get a urinary tract infection from that catheter.

4 Jan 2008

BD Diagnostics announces FDA clearance of test to identify superbug

BD Diagnostics, a segment of BD (Becton, Dickinson and Company), has announced that it received clearance from the U.S. Food and Drug Administration (FDA) for the BD GeneOhm StaphSR assay.

From BD (Becton, Dickinson and Company) 3 Jan 2008

New drug targets may fight tuberculosis and other bacterial infections in novel way

Over the course of the 20th Century, doctors waged war against infectious bacterial illness with the best new weapon they had: antibiotics.

28 Dec 2007

Paradigm shift in TB: virulence factors, not antibiotics

Over the course of the 20th Century, doctors waged war against infectious bacterial illness with the best new weapon they had: antibiotics.

27 Dec 2007

Poultry workers at greater risk of carrying antibiotic-resistant E. coli

Poultry workers in the United States are 32 times more likely to carry E. coli bacteria resistant to the commonly used antibiotic, gentamicin, than others outside the poultry industry, according to a recent study conducted by researchers at the Johns Hopkins Bloomberg School of Public Health.

18 Dec 2007

Intracellular bacterial communities in cystitis; rifapentine cures TB in mouse model; and more

A study published this week in the open access journal PLoS Medicine presents convincing evidence that intracellular bacterial communities (IBCs) commonly exist in women with bladder infections and may contribute to the recurrence of these infections.

18 Dec 2007

Antibacterial chemical in bath soaps disrupts hormone activities

A new UC Davis study shows that a common antibacterial chemical added to bath soaps can alter hormonal activity in rats and in human cells in the laboratory - and does so by a previously unreported mechanism.

10 Dec 2007

Purified bacterial extract sprayed into lungs ramps up innate immune system

A purified extract prepared from a common microbe and delivered to the lungs of laboratory mice in a spray set off a healthy immune response and provided powerful protection against all four major classes of pathogens including those responsible for anthrax and bubonic plague, according to a presentation at the American Society for Cell Biology's 47th Annual Meeting.

4 Dec 2007

Cethromycin achieves all endpoints in second pivotal Phase III Trial for treatment for pneumonia

Advanced Life Sciences Holdings, Inc. (Nasdaq: ADLS), today announced positive results from Trial CL-05, the second of two pivotal phase III clinical trials designed to assess the safety and effectiveness of cethromycin, a novel once-a-day oral antibiotic for the treatment of mild-to-moderate community acquired pneumonia (CAP), the sixth leading cause of death in the United States.

16 Nov 2007