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Targeted therapy combo overcomes treatment resistance in liver cancer

Researchers at the University of Pennsylvania School of Medicine and Abramson Cancer Center reported at the annual meeting of the American Association for Cancer Research that combining two targeted therapies overcomes treatment resistance in liver cancer cell lines.

13 Apr 2008

Medicare reimbursement changes likely influenced changes in prostate cancer treatment

Financial pressures from Medicare reimbursement changes may have caused physicians to switch from providing hormonal-induced castration to providing surgical castration for men with prostate cancer.

13 Apr 2008

Angina drug ranolazine potentially useful against heart rhythm disorders

A recently approved angina drug may also represent a powerful new treatment for a rare hereditary syndrome that places teens at risk for sudden cardiac death, according to research presented on April 1st at the 57th Annual Scientific Sessions of the American College of Cardiology (ACC) in Chicago.

9 Apr 2008

Aripiprazole has potential for treating alcohol dependence

Aripiprazole is currently approved to treat bipolar disorder as well as schizophrenia. A new study has found that it significantly and dose-dependently increases the sedative effects of alcohol and, to a lesser degree, decreases the euphoric effects of alcohol. Future research will need to examine the beneficial versus the side effects of aripiprazole for treatment of alcohol dependence.

4 Apr 2008

Asthma medicines often not prescribed as guidelines recommend

More than a decade after national guidelines were issued for asthma treatment, some patients still don't receive prescriptions for the inhalers that experts say offer the safest and most effective long-term control of the disease, a new study suggests.

20 Mar 2008

Potential new neuronal tumor suppressor

In a G&D paper published online ahead of its April 1 print publication date, Dr. William Kaelin (Dana Farber Cancer Institute) and colleagues identify a potential new neuronal tumor suppressor.

18 Mar 2008

New Parkinson's disease research points to serotonin

For most people with Parkinson's disease, the only relief from the tremors, rigidity and impaired movement associated with the progressive loss of their motor skills is a drug called L-DOPA. But as the disease progresses, L-DOPA can cause prominent side effects that counteract its effectiveness.

4 Feb 2008

Altering brain's lipid metabolism reduces Alzheimer's plaques in mice

Increasing levels of a protein that helps the brain use cholesterol may slow the development of Alzheimer's disease changes in the brain, according to researchers studying a mouse model of the disease at Washington University School of Medicine in St. Louis.

18 Jan 2008

Taranabant shows promise for weight loss in obese people

The first clinical studies of an experimental drug have revealed that obese people who take it for 12 weeks lose weight, even at very low doses.

9 Jan 2008

Intensive care quality of sleep improved by new drug dexmedetomidine

A new sedative drug has been shown to improve the sleep quality and comfort levels of intensive care patients, compared to the most commonly-used medication, according to research published today in the journal JAMA.

13 Dec 2007

Bionovo describes a new class of therapeutic compounds

Bionovo, Inc. has announced the publication of a groundbreaking paper in the journal Molecular and Cellular Endocrinology covering the isolation, identification and description of a pure chemical compound, liquiritigenin, which represents a new class of therapeutic compounds showing promise for the safe treatment of menopausal symptoms.

2 Dec 2007

New clinical standards on the treatment of patients with cystic fibrosis

New clinical standards on the treatment of patients with cystic fibrosis (CF) have been released following an exhaustive review of all available literature.

16 Nov 2007

Brain may have important influences on glucose metabolism and insulin action

An appetite-suppressing chemical also improves glucose tolerance and lowers insulin levels in obese and diabetic mice, researchers report in the November issue of Cell Metabolism, a publication of Cell Press.

13 Nov 2007

Managing asthma

The great majority of the nearly 23 million people with asthma, including 6.5 million children, can avoid serious symptoms and disability if they follow the latest guidelines to keep their disease under control.

13 Nov 2007

Brain appears to play important role in glucose metabolism and insulin action

6 Nov 2007

Attenuation of NASH by stimulation of free fatty acid metabolism

Medically-complicated obesity is a societal problem that needs to be solved. Liver disease, specifically non-alcoholic steatohepatitis or NASH, is just one of the many complications of increased body weight.

28 Oct 2007

Safety of nebulized Formoterol in COPD

Data from two Phase III clinical trials were presented today in Chicago at CHEST 2007, the annual scientific assembly of the American College of Chest Physicians (ACCP), supporting the use of Perforomist (formoterol fumarate) Inhalation Solution as a safe and effective maintenance treatment for COPD patients.

24 Oct 2007

New therapy for chronic spasticity and rigidity

Research led by scientists at the University of California, San Diego (UCSD) School of Medicine has identified a target with potential as an effective new therapy for chronic spasticity and rigidity, a painful condition that often results from spinal cord injury.

17 Oct 2007

Findings could lead to new therapy for spinal cord injury

17 Oct 2007

Dermatology's role in advancing the science of wound care

Cosmetic, medical and surgical dermatologists all play a role in the treatment and management of wounds, according to an editorial in the October issue of Archives of Dermatology, a theme issue on wound healing.

16 Oct 2007