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Upregulation of Robo4 expression reduces mortality from severe infection

The researchers screened a library of drugs using a mouse endothelial cell line to identify pathways that are involved in the regulation of Robo4 and found that two competitive SMAD signaling pathways appear to regulate Robo4 expression.

18 Jan 2023

Exposure to World Trade Center particulate matter accelerates cognitive deterioration in mice model of Alzheimer's

Mice exposed to World Trade Center dust exhibit a significant impairment in spatial recognition and short- and long-term memory, as well as changes in genes related to immune-inflammatory responses and blood-brain barrier disruption, according to a study conducted by researchers from the Icahn School of Medicine at Mount Sinai and published January 17 in the Journal of Alzheimer's Disease.

17 Jan 2023

What are the major findings of long COVID research?

Researchers explored existing literature on long coronavirus disease (COVID). They highlighted key immunological findings, similarities with other diseases, symptoms, and associated pathophysiological mechanisms, and diagnostic and therapeutic options, including COVID-19 vaccinations.

17 Jan 2023

COPD patients have decreased survival and increased costs in the year after surgery

Patients with chronic obstructive pulmonary disease (COPD) who undergo major surgery are more likely to die in the year after surgery and incur higher health care costs than similar patients without COPD, found a new study published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.220733.

17 Jan 2023

Endothelial cell-specific protein Robo4 reduces mortality in severe infection

Pipes play an essential role in bringing water to the faucets in your home, but if one of those pipes springs a leak, damage can result.

16 Jan 2023

Walking pace and handgrip strength can indicate dementia risk

The current study, published in the journal Alzheimer's Research & Therapy, drew data on almost 496,000 participants from the UK Biobank Study. None had symptoms or a diagnosis of dementia at the start of the study.

15 Jan 2023

Study directly links gut leakage with retinopathy severity in people with Type 1 diabetes

The leading cause of blindness in American adults is diabetic retinopathy, progressive damage to blood vessels in the light-sensitive tissue at the back of the eye.

14 Jan 2023

Risks and benefits of recently approved Alzheimer’s drug

The U.S. Food and Drug Administration (FDA) recently granted approval to Lecanemab, the first Alzheimer's disease treatment to win approval since the largely failed rollout of Aduhelm two years ago.

13 Jan 2023

CNB-CSIC vaccine fully protects against SARS-CoV-2 infection of the brain

In a recent study published in the journal Nature Neuroscience, researchers in Spain described the effectiveness of a modified vaccinia virus Ankara (MVA) vector severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine candidate in protecting against SARS-CoV-2 infection in the brain using a mouse model.

12 Jan 2023

The same genetic factors may contribute to both cardiometabolic diseases and dementia

Being affected by several cardiometabolic diseases such as diabetes, heart disease and stroke, is linked to a greatly increased risk of dementia and Alzheimer's disease.

12 Jan 2023

Simple method increases the efficacy of T cell therapy by cytokine conjugation

The recent years have seen a wave of adoptive cell therapies (ACTs), a type of immunotherapy in which T cells (T cell transfer therapy) and other immune cells are obtained from patients, activated and multiplied outside the body, and infused in larger numbers back into the blood circulation to help fight cancers.

11 Jan 2023

2022: a year in MIS-C research

In a recent review published in Nature Reviews Rheumatology, researchers reviewed existing data on the multisystem inflammatory syndrome in children (or MIS-C).

11 Jan 2023

Study identifies LAP1 as a master regulator of nuclear envelope remodeling during melanoma progression

Researchers discovered that the elevated expression of LAP1, an inner nuclear membrane protein, helps metastatic melanoma cells surmount the physical challenges presented by tissue structure and the microenvironment during metastasis.

11 Jan 2023

Protein Medin: A new treatment target for Alzheimer's

A recent study published in the journal Nature reported the co-aggregation of medin, a fragment of lactadherin, with vascular amyloid-β in Alzheimer’s disease (AD).

10 Jan 2023

What are the effects of prenatal exposure to alcohol and marijuana on fetal development?

Researchers presented the effects of simultaneous alcohol and cannabinoid (SAC) usage during gestation on fetal brain development.

10 Jan 2023

Are hospitalizations with infection associated with dementia incidence?

A recent study reveals that hospitalized patients with infection are at higher risk of developing dementia.

10 Jan 2023

Study: Two separate eye diseases may contribute to age-related macular degeneration

Two separate eye diseases may contribute to age-related macular degeneration (AMD), a leading cause of blindness in the United States, according to a new study from New York Eye and Ear Infirmary of Mount Sinai.

9 Jan 2023

Researchers develop a novel, improved system for identifying fluorescent agents

The nascent field of fluorescence-guided surgery (FGS) is fast growing, with potential to vastly improve the safety and efficacy of surgical procedures.

9 Jan 2023

New electrically conductive hydrogel scaffold supports neural cell differentiation

Brain-computer interfaces (BCIs) are a hot topic these days, with companies like Neuralink racing to create devices that connect humans' brains to machines via tiny implanted electrodes.

5 Jan 2023

Mediterranean diet may benefit health in part by incorporating moderate wine consumption

Many public health warnings have been issued against alcohol consumption, even in small quantities, though the evidence for such strict limits is controversial. The current study, published in the MDPI journal Nutrients, is a narrative review focused on clearing up some of the confusion associated with alcoholic drinks.

4 Jan 2023

Vascular News and Research

Upregulation of Robo4 expression reduces mortality from severe infection

Exposure to World Trade Center particulate matter accelerates cognitive deterioration in mice model of Alzheimer's

What are the major findings of long COVID research?

COPD patients have decreased survival and increased costs in the year after surgery

Endothelial cell-specific protein Robo4 reduces mortality in severe infection

Walking pace and handgrip strength can indicate dementia risk

Study directly links gut leakage with retinopathy severity in people with Type 1 diabetes

Risks and benefits of recently approved Alzheimer’s drug

CNB-CSIC vaccine fully protects against SARS-CoV-2 infection of the brain

The same genetic factors may contribute to both cardiometabolic diseases and dementia

Simple method increases the efficacy of T cell therapy by cytokine conjugation

2022: a year in MIS-C research

Study identifies LAP1 as a master regulator of nuclear envelope remodeling during melanoma progression

Protein Medin: A new treatment target for Alzheimer's

What are the effects of prenatal exposure to alcohol and marijuana on fetal development?

Are hospitalizations with infection associated with dementia incidence?

Study: Two separate eye diseases may contribute to age-related macular degeneration

Researchers develop a novel, improved system for identifying fluorescent agents

New electrically conductive hydrogel scaffold supports neural cell differentiation

Mediterranean diet may benefit health in part by incorporating moderate wine consumption

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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