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Preterm infants born in lower-level hospitals show high mortality rates: Study

An analysis of data from previously published studies indicates that very low-birth-weight and very preterm infants not born in highly specialized, level III hospitals have an associated higher likelihood of neonatal and predischarge death compared to similar infants born at level III hospitals, according to an article in the September 1 issue of JAMA.

2 Sep 2010

Sangart reports positive MP4OX Phase IIa study data in severely injured trauma patients with hemorrhagic shock

Sangart, Inc., today announced positive results from its Phase IIa proof-of-concept study of MP4OX (oxygenated pegylated hemoglobin) in severely injured trauma patients with hemorrhagic shock causing lactic acidosis. The study demonstrated that MP4OX, when given in addition to standard of care, was effective at decreasing lactate levels in treated patients.

2 Sep 2010

Sangart reports positive data from MP4OX Phase IIa study in trauma patients

31 Aug 2010

DANPACE trial shows dual chamber pacing decreases atrial fibrillation in sick sinus syndrome

DANPACE, a Danish multicentre randomised trial comparing single lead atrial and dual chamber pacing in patients with sick sinus syndrome, concludes that dual chamber pacing, which was associated with lower rates of atrial fibrillation and re-operation, "should be the preferred pacing mode".

31 Aug 2010

$Unfractionated heparin standard dose may be optimal treatment strategy in PCI patients on fondaparinux$

Unfractionated heparin standard dose may be optimal treatment strategy in PCI patients on fondaparinux

Results from the FUTURA/OASIS 8 study presented today at the ESC Congress provide initial evidence that a low dose of unfractionated heparin does not reduce the incidence of bleeding or vascular complications in PCI patients treated with the anticoagulant fondaparinux. Findings showed that the rates of peri-PCI major bleeding were 1.4% in those given low dose heparin and 1.2% the standard dose.

31 Aug 2010

Genetic profiling to predict treatment benefits of ACE inhibitor therapy for CAD

The advantages of prescribing angiotensin-converting enzyme (ACE) inhibitors for stable coronary artery disease (CAD) may be increased by targeting the therapy to the patients most likely to benefit.Clinical characteristics alone do not allow a reliable identification of these patients, so a research programme was carried out at Erasmus University Medical Centre in Rotterdam to develop a genetic profiling model that predicts the treatment benefits of ACE inhibitors and optimises the recommended therapy.

31 Aug 2010

Using clopidogrel, PPIs increases cardiac damage risk: Study

Patients with coronary artery disease undergoing stent implantation are often prescribed the antiplatelet drug, clopidogrel. This drug prevents blood clots, but is known to have a side-effect that can cause stomach bleeding. Consequently, many users are also prescribed a proton pump inhibitor (PPI). Now, however, a meta-analysis of almost 160,000 patients carried out at the Medical University of Vienna and Wilhelminenhospital, Vienna, has shown that simultaneous use of these drugs can increase the risk of cardiac damage.

31 Aug 2010

Data suggests BIMA improves coronary artery bypass graft efficiency

Recent trial data indicate that coronary artery bypass graft (CABG) surgery remains the most effective intervention for patients with severe coronary artery disease (CAD).

31 Aug 2010

Over use of decongestants by women leads to preterm birth delivery: Study

A new study led by Boston University School of Public Health (BUSPH) epidemiologists has found that women who took over-the-counter decongestants during their pregnancies are less likely to give birth prematurely.

31 Aug 2010

Opinions: MDG progress; Drug patents; Aid for scientific research; Avoiding food crises; Hunger in India; U.S. commitments to PEPFAR, Global Fund

"Between the catastrophes of the Haiti earthquake and the Pakistan floods, there was actually some good news this spring on the global health front, which offers hope that the United Nations' ambitious Millennium Development Goals might not be at a standstill. Though a great deal remains to be done, all of us are living longer, fewer mothers are dying in childbirth, and fewer children are dying before school age," Eli Adashi, professor of medical science at Brown University, writes in Boston Globe editorial.

30 Aug 2010

Selective lowering of heart rate reduces risk of death and hospitalization: Study

The results of a major international study presented at the European Society of Cardiology Congress in Stockholm and published simultaneously in The Lancet show, for the first time, that selectively lowering heart rate with a novel medication, ivabradine, significantly reduces risk of death and hospitalization for patients with heart failure. This also resolves a longstanding debate about whether lowering heart rate itself can actually lower the risk of heart disease progression.

30 Aug 2010

MedCath to sell interest in Avera Heart Hospital of South Dakota to Avera McKennan

MedCath Corporation announced today it has entered into a definitive agreement to sell its subsidiary which is the indirect owner of a one-third ownership interest and management rights in Avera Heart Hospital of South Dakota to Avera McKennan. The transaction is expected to close in 45 to 90 days, subject to certain closing conditions.

30 Aug 2010

Low doses of n-3 fatty acids do not reduce overall rate of major cardiovascular events

Results from the Alpha Omega Trial, a multicentre, placebo-controlled trial in men and women following myocardial infarction (MI), suggest that low doses of n-3 fatty acids given in the form of enriched margarines do not reduce the overall rate of major cardiovascular events.

30 Aug 2010

SHIFT study finds Ivabradine reduces heart failure risk

Ivabradine, a selective If inhibitor already investigated for its effects in coronary artery disease and left ventricular dysfunction, significantly lowers the risk of heart failure, according to results of the SHIFT study (Systolic Heart failure treatment with the If inhibitor ivabradine Trial).

30 Aug 2010

Study finds bone marrow stem cell therapy improves efficacy in chronic heart failure

Bone marrow stem cell therapy improves ventricular performance, quality of life and survival in patients with chronic heart failure, according to results from the STAR-heart study.

30 Aug 2010

ATOLL study favors enoxaparin over UFH for primary Percutaneous Coronary Intervention

The international ATOLL study sponsored by the Assistance Publique - Hopitaux de Paris showed that enoxaparin reduced the composite of death, complication of myocardial infraction, procedure failure or major bleeding by 17% in comparison with standard heparin death, recurrent acute coronary syndrome or urgent revascularisation. The results of the ATOLL study were presented at the hotline session of the annual European Cardiology Congress (ESC 2010) in Stockholm, Sweden.

30 Aug 2010

Recent releases in Global Health

"[N]ew diagnostic techniques [for tuberculosis] need to be studied in children," according to a Lancet Infectious Diseases Reflection. "Tuberculosis is an important cause of morbidity and mortality in children worldwide, but estimates of disease burden are inaccurate because most cases are not confirmed," the author writes. He discusses a study published in the same issue that examines various methods for diagnosing TB in children.

27 Aug 2010

Exmovere to release vital sign monitoring infant sleepwear

Exmovere Holdings, Inc., a biomedical engineering company, today announced plans to release vital sign monitoring infant sleepwear. Exmovere is in the advanced stages of taking to market a washable, conductive fabric-based biosensor pajama called "Exmobaby." Exmobaby is the first-ever baby garment developed for remote monitoring of heart rate, emotional state and behavior.

27 Aug 2010

Expansion of rapid response systems throughout the Veterans Affairs network can reduce morbidity

Implementing a rapid response team to aid in managing "potentially unstable" patients has led to a sharp reduction in the rate of cardiac arrests at a U.S. Veterans Affairs (VA) hospital, reports a study in the September issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

27 Aug 2010

Researchers recommend traumatic brain injury reclassification for additional funding

Traumatic brain injury, currently considered a singular event by the insurance industry and many health care providers, is instead the beginning of an ongoing process that impacts multiple organ systems and may cause or accelerate other diseases and disorders that can reduce life expectancy, according to research from the University of Texas Medical Branch at Galveston.

27 Aug 2010

Mortality News and Research

Preterm infants born in lower-level hospitals show high mortality rates: Study

Sangart reports positive MP4OX Phase IIa study data in severely injured trauma patients with hemorrhagic shock

Sangart reports positive data from MP4OX Phase IIa study in trauma patients

DANPACE trial shows dual chamber pacing decreases atrial fibrillation in sick sinus syndrome

Unfractionated heparin standard dose may be optimal treatment strategy in PCI patients on fondaparinux

Genetic profiling to predict treatment benefits of ACE inhibitor therapy for CAD

Using clopidogrel, PPIs increases cardiac damage risk: Study

Data suggests BIMA improves coronary artery bypass graft efficiency

Over use of decongestants by women leads to preterm birth delivery: Study

Opinions: MDG progress; Drug patents; Aid for scientific research; Avoiding food crises; Hunger in India; U.S. commitments to PEPFAR, Global Fund

Selective lowering of heart rate reduces risk of death and hospitalization: Study

MedCath to sell interest in Avera Heart Hospital of South Dakota to Avera McKennan

Low doses of n-3 fatty acids do not reduce overall rate of major cardiovascular events

SHIFT study finds Ivabradine reduces heart failure risk

Study finds bone marrow stem cell therapy improves efficacy in chronic heart failure

ATOLL study favors enoxaparin over UFH for primary Percutaneous Coronary Intervention

Recent releases in Global Health

Exmovere to release vital sign monitoring infant sleepwear

Expansion of rapid response systems throughout the Veterans Affairs network can reduce morbidity

Researchers recommend traumatic brain injury reclassification for additional funding

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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