Genes News and Research

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Scientists develop mathematical model to predict tumor behavior and personalized therapies

Dana-Farber Cancer Institute scientists have developed a mathematical model to predict how a patient's tumor is likely to behave and which of several possible treatments is most likely to be effective.

24 Jan 2014

Scientists map genetic changes that drive tumors pediatric soft-tissue cancer

Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes.

24 Jan 2014

CUMC researchers identify gene that appears to play major role in motor neuron degeneration in ALS

Columbia University Medical Center researchers have identified a gene, called matrix metalloproteinase-9 (MMP-9), that appears to play a major role in motor neuron degeneration in amyotrophic lateral sclerosis, also known as Lou Gehrig's disease. The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still-incurable neurodegenerative disease. The study was published today in the online edition of the journal Neuron.

23 Jan 2014

Research reveals new information about the genetic complexity underpinning schizophrenia

The Icahn School of Medicine at Mount Sinai today announced the publication of two papers in the journal Nature that reveal new information about the genetic complexity underpinning schizophrenia. These collaborative studies represent the largest exome sequencing efforts to date to elucidate this mental illness, and together found that the disorder is likely caused by far more rare genetic mutations than previously suspected.

23 Jan 2014

Inovio Pharmaceuticals unveils new DNA-based cytokine immune activator

Inovio Pharmaceuticals, Inc. today unveiled that the company has developed a new DNA-based cytokine immune activator, interleukin -33 (IL-33), that in combination with optimized DNA vaccines delivered by electroporation increased the potency and efficacy of the therapeutic response to the DNA vaccines in a preclinical study.

23 Jan 2014

New heart tissue could help patients suffering from irreparable damage

In the U.S., someone suffers a heart attack every 34 seconds - their heart is starved of oxygen and suffers irreparable damage. Engineering new heart tissue in the laboratory that could eventually be implanted into patients could help, and scientists are reporting a promising approach tested with rat cells.

23 Jan 2014

Researchers discover new gene involved in severe childhood epilepsy

A European consortium of epilepsy researchers has reported the discovery of a new gene involved in severe childhood epilepsy. Using a novel combination of technologies, including trio exome sequencing of patient/parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome - a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

23 Jan 2014

Researchers identify five new genes associated with increased waist-to-hip ratio

Excess abdominal fat can be a precursor to diseases such as cardiovascular disease, type 2 diabetes and cancer. A person's measure of belly fat is reflected in the ratio of waist circumference to hip circumference, and it is estimated that genetics account for about 30-60 percent of waist-to-hip ratio.

23 Jan 2014

NCCC physicians use new gene sequencing equipment for testing abnormal DNA in cancerous tumor cells

Clinical laboratory experts and physicians at Dartmouth-Hitchcock Norris Cotton Cancer Center (NCCC) achieved 100 percent accuracy in testing for abnormal DNA in cancerous tumor cells with its new gene sequencing equipment and panels.

23 Jan 2014

Scientists develop new genetic platform that yields novel antibiotic from ocean bacteria

Scientists at the University of California, San Diego have developed a new genetic platform that allows efficient production of naturally occurring molecules, and have used it to produce a novel antibiotic compound.

23 Jan 2014

Researchers find that 20% of women with ovarian cancer had inherited mutations in gene pathway

A new study conservatively estimates that one in five women with ovarian cancer has inherited genetic mutations that increase the risk of the disease, according to research at Washington University School of Medicine in St. Louis.

23 Jan 2014

Chinese and American researchers introduce new approach to gene therapy

Resistance of tumor cells toward multiple cytostatic drugs is a serious problem in cancer treatment. In the journal Angewandte Chemie, a team of Chinese and American researchers has now introduced a new approach to gene therapy that could counter this problem: The gene that codes for resistance is “silenced” through the use of an ingenious nanocomplex.

22 Jan 2014

Blood methylome offers clues to schizophrenia

Researchers show that a methylome-wide association study of the blood can provide a glimpse of past environmental insults that may contribute to the development of schizophrenia.

22 Jan 2014

Long-term exposure to particulate matter linked with increased risk for heart attack

Long-term exposure to particulate matter is associated with an increased risk for heart attack. Moreover, this association can already be observed in levels of particulate exposure below the current specified European limit values.

22 Jan 2014

Researchers assess familial risks for MS using population registers, health care registries

Even though multiple sclerosis is largely caused by genetic factors, the risk of patients' relatives developing the disease is lower than previously assumed. This is the conclusion of a new population registry-based study, published in the scientific journal Brain.

22 Jan 2014

Study ultimately could lead to development of screening test for diagnosing bladder cancer

Findings from a Loyola University Medical Center study ultimately could lead to tests to screen for and diagnose bladder cancer.

22 Jan 2014

UT Southwestern' faculty receives Stanley J. Korsmeyer Award for contributions to understanding of autophagy

Dr. Beth Levine, a Howard Hughes Medical Institute Investigator and Director of the Center for Autophagy Research at UT Southwestern Medical Center, has received the 2014 Stanley J. Korsmeyer Award from the American Society for Clinical Investigation.

22 Jan 2014

Clues of "silent thief of sight”: Glaucoma

Glaucoma is sometimes called the "silent thief of sight" because it slowly damages the eyes and can cause irreparable harm before there is any vision loss. But this disease is stealthy in more ways than one.

22 Jan 2014

Researchers demonstrate existence of an epigenetic lesion in hippocampus of Alzheimer patients

Alzheimer's disease can reach epidemic range in the coming decades, by the increasing average age of society. There are two key issues for Alzheimer's disease: there is currently no effective treatment and it has been described very few associated genetic changes (mutations) which reduces the number of targets for future therapies.

22 Jan 2014

Parkin and PINK1 function in vesicular trafficking pathway regulates mitochon-drial quality control

Scientists from the Montreal Neurological Institute and Hospital in Canada have discovered that two genes linked to hereditary Parkinson's disease are involved in the early-stage quality control of mitochondria.

22 Jan 2014

Genes News and Research

Scientists develop mathematical model to predict tumor behavior and personalized therapies

Scientists map genetic changes that drive tumors pediatric soft-tissue cancer

CUMC researchers identify gene that appears to play major role in motor neuron degeneration in ALS

Research reveals new information about the genetic complexity underpinning schizophrenia

Inovio Pharmaceuticals unveils new DNA-based cytokine immune activator

New heart tissue could help patients suffering from irreparable damage

Researchers discover new gene involved in severe childhood epilepsy

Researchers identify five new genes associated with increased waist-to-hip ratio

NCCC physicians use new gene sequencing equipment for testing abnormal DNA in cancerous tumor cells

Scientists develop new genetic platform that yields novel antibiotic from ocean bacteria

Researchers find that 20% of women with ovarian cancer had inherited mutations in gene pathway

Chinese and American researchers introduce new approach to gene therapy

Blood methylome offers clues to schizophrenia

Long-term exposure to particulate matter linked with increased risk for heart attack

Researchers assess familial risks for MS using population registers, health care registries

Study ultimately could lead to development of screening test for diagnosing bladder cancer

UT Southwestern' faculty receives Stanley J. Korsmeyer Award for contributions to understanding of autophagy

Clues of "silent thief of sight”: Glaucoma

Researchers demonstrate existence of an epigenetic lesion in hippocampus of Alzheimer patients

Parkin and PINK1 function in vesicular trafficking pathway regulates mitochon-drial quality control

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