Genetic Engineering News and Research

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Consuming sesame-based ingredients may reduce oxidative stress

The antioxidant boosting properties of sesame, and especially sesame oil, can have a significant effect on oxidative stress, improving human health, according to a systematic review published in Journal of Medicinal Food, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

18 May 2016

Sleeve gastrectomy can give optimal outcomes even in sweet eaters

Sleeve gastrectomy is a novel bariatric surgical procedure showing promising weight loss results, even among individuals classified as moderate or severe sweet eaters before the surgery.

15 May 2016

Researchers develop novel ss-siRNAs to turn off disease-related genes

Combining the therapeutic potential and advantages of existing oligonucleotide-based approaches to turn off disease-related genes, a type of single-stranded silencing RNAs (ss-siRNAs) has shown significantly improved potency and activity.

13 May 2016

McGill researchers discover brain cells that play key role in leptin sensing, weight gain

It's rare for scientists to get what they describe as "clean" results without spending a lot of time repeating the same experiment over and over again. But when researchers saw the mice they were working with doubling their weight within a month or two, they knew they were on to something.

13 May 2016

Mouse models of Zika virus infection in pregnancy provide basis to develop vaccines, treatments

Two mouse models of Zika virus infection in pregnancy have been developed by a team of researchers at Washington University School of Medicine in St. Louis. In them, the virus migrated from the pregnant mouse's bloodstream into the placenta, where it multiplied, then spread into the fetal circulation and infected the brains of the developing pups.

12 May 2016

High-throughput screening can help detect multiple compounds with potent antimicrobial activity

A new study in which researchers rapidly screened more than 11,000 bioactive molecules for activity against an antibiotic-resistant strain of Klebsiella pneumoniae bacteria identified multiple compounds with potent antimicrobial activity.

12 May 2016

New study explores impact of infant feeding practices on childhood obesity risk

Does the timing of introducing solid foods to the infant diet affect a child's risk of being obese by 6 years of age? A new study from the Centers for Disease Control and Prevention (CDC) analyzed data on infant feeding practices, with a 6-year follow-up to determine obesity, and also explored the potential impact of breast versus formula feeding.

12 May 2016

Patient-specific immunotherapeutic vaccines may improve overall survival of melanoma patients

Two patients with melanoma that had spread to the liver survived for at least 8.5 and 12 years after resection of the hepatic tumor and treatment with patient-specific immunotherapeutic vaccines.

11 May 2016

Unique attributes of zebrafish may help study human blood disorders

Genetic regulation of the various types of blood cells in zebrafish and humans is highly similar, making it relatively easy and cost-effective to perform genetic, chemical, imaging and other molecular studies on this invaluable model organism to study normal hematopoetic development in humans as well as blood disorders and malignancies, as described in a Review article in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

9 May 2016

Novel animal model helps understand mechanisms that lead to multiple myeloma

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have developed an animal model that allows them to better understand the mechanisms that lead to the development of multiple myeloma, a hematologic cancer of plasma cells, and the amyloidosis that sometimes accompanies it. The study was published in the journal Scientific Reports.

6 May 2016

Globin gene transfer to treat beta-thalassemias shows promise in first clinical trial

Promising results from the first clinical trials of globin gene transfer to treat beta-thalassemias-inherited forms of anemia-have eliminated the need for blood transfusions in some individuals.

6 May 2016

Better understanding of mechanisms linked to human heart valve disease

A cell-to-cell signaling network that serves as a developmental timer could provide a framework for better understanding the mechanisms underlying human heart valve disease, say University of Oregon scientists.

6 May 2016

Enzyme previously thought beneficial could pose threat to developing embryos

A pair of Oklahoma Medical Research Foundation scientists have discovered that an enzyme previously thought only to be beneficial could, in fact, pose significant danger to developing embryos. The new research could have implications not only for prenatal development but also for treating lymphedema and liver damage resulting from acetaminophen overdose.

5 May 2016

Certain sugars in the body play key role in colitis, colon cancer development

An Oklahoma Medical Research Foundation scientist has discovered that certain sugars produced by the body play an important role in the development of colitis and, ultimately, colon cancer. The new finding could potentially lead to therapies for ulcerative colitis, Crohn's disease and colon cancer.

5 May 2016

New study links cathepsin S protein to tear secretion in Sjogren's syndrome patients

The autoimmune disorder Sjogren's syndrome is often overlooked or misdiagnosed because the symptoms are similar to other conditions. Its characteristic symptoms are dry eyes and dry mouth, and reduced tear production is used as part of the diagnosis.

4 May 2016

Ebola vaccine shows promise in clinical trials

"The results for tolerability, safety, and the immune response to the vaccine candidate are very promising," explains Prof Marylyn Addo. The antibodies which developed against the virus were still detectable after six months. Addo is convinced, "With this, a single vaccine could provide lasting protection against Ebola." The infectious disease specialist, who works for the German Center for Infection Research at the University Medical Center Hamburg Eppendorf in Hamburg, led the trial in Hamburg.

4 May 2016

Study reveals long-term health-related quality of life in bariatric surgery patients

Significant improvement in health-related quality of life was reported by patients 12-14 years after undergoing an uncommon form of bariatric surgery at one U.S. medical center. Follow-up of the 27 patients who underwent biliary pancreatic diversion surgery with duodenal switch (BPD-DS) by the same surgeon is described in an article in Bariatric Surgical Practice and Patient Care, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free for download until June 2, 2016.

3 May 2016

Excess abdominal fat in obese African American women could hide symptoms of ovarian cancer

African American women with ovarian cancer are more likely to die from the disease than are White women and they are also much more likely to be obese. These factors may be linked by the new finding that excess abdominal fat in overweight and obese women could interfere with the detection of early symptoms of ovarian cancer, as presented in a study published in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Women's Health website until May 28, 2016.

29 Apr 2016

Studies on role of vitamin A in heart health have drawn opposite conclusions

Vitamin A is involved in many bodily processes, including vision and skin health, but its role in the heart is unclear. While vitamin A is critical for heart development of embryos—vitamin A deficiency during pregnancy leads to an abnormal heart and prenatal death—studies on vitamin A's role in heart health have drawn opposite conclusions.

29 Apr 2016

Dopamine neuron transplants controlled by designer drug may fight Parkinson's disease in mice

A University of Wisconsin-Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell. The cells in question are neurons and make the neurotransmitter dopamine, whose deficiency is the culprit in the widespread movement disorder Parkinson's disease.

29 Apr 2016

Genetic Engineering News and Research

Consuming sesame-based ingredients may reduce oxidative stress

Sleeve gastrectomy can give optimal outcomes even in sweet eaters

Researchers develop novel ss-siRNAs to turn off disease-related genes

McGill researchers discover brain cells that play key role in leptin sensing, weight gain

Mouse models of Zika virus infection in pregnancy provide basis to develop vaccines, treatments

High-throughput screening can help detect multiple compounds with potent antimicrobial activity

New study explores impact of infant feeding practices on childhood obesity risk

Patient-specific immunotherapeutic vaccines may improve overall survival of melanoma patients

Unique attributes of zebrafish may help study human blood disorders

Novel animal model helps understand mechanisms that lead to multiple myeloma

Globin gene transfer to treat beta-thalassemias shows promise in first clinical trial

Better understanding of mechanisms linked to human heart valve disease

Enzyme previously thought beneficial could pose threat to developing embryos

Certain sugars in the body play key role in colitis, colon cancer development

New study links cathepsin S protein to tear secretion in Sjogren's syndrome patients

Ebola vaccine shows promise in clinical trials

Study reveals long-term health-related quality of life in bariatric surgery patients

Excess abdominal fat in obese African American women could hide symptoms of ovarian cancer

Studies on role of vitamin A in heart health have drawn opposite conclusions

Dopamine neuron transplants controlled by designer drug may fight Parkinson's disease in mice

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