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Missing proteins explain century-old mystery of scalp skin absence in children

Children with the condition aplasia cutis congenita (ACC) are born with the absence of skin along the midline of the scalp.

3 Jan 2024

Researchers uncover variations in how IBD affects people of different races, sexes and places of birth

Researchers from Rutgers and other institutions have uncovered significant variations in how inflammatory bowel disease (IBD) affects people of different races, sexes and places of birth.

3 Jan 2024

New study demystifies clinicians' decision-making process for drug-drug interactions

Drug-drug interactions causing adverse effects are common and can cause significant patient harm and even death.

3 Jan 2024

New brain imaging technique sheds light on invisible mTBIs

Researchers have created a new brain imaging method that allows mild traumatic brain injuries (mTBIs) to be diagnosed, even when existing imaging techniques like magnetic resonance imaging (MRI) don't show any structural abnormalities.

3 Jan 2024

MGH study identifies key proteins linked to pregnancy hypertension disorders

Preeclampsia and other hypertensive disorders of pregnancy - which are characterized by high blood pressure with or without organ dysfunction during the second half of pregnancy - carry considerable short- and long-term risks for both the mother and child. Treatment options (other than expedited delivery) remain limited.

3 Jan 2024

Existing beta blocker investigated as novel sickle cell therapy

A beta blocker typically used to treat heart problems, hemangioma, migraines and anxiety could be a new therapeutic for patients with sickle cell disease. Researchers led by Ankit A. Desai, MD, associate professor of medicine at the Krannert Cardiovascular Research Center (KCVRC) at Indiana University School of Medicine, have been awarded a $3 million grant by the U.S. Department of Defense to evaluate the efficacy of this drug.

3 Jan 2024

Enlarged perivascular spaces in infancy associated with sleep problems and autism risk

Throughout the day and night, cerebrospinal fluid (CSF) pulses through small fluid-filled channels surrounding blood vessels in the brain, called perivascular spaces, to flush out neuroinflammation and other neurological waste.

2 Jan 2024

Study identifies α-MSH as therapeutic candidate for corneal endothelial disease

Findings from a pioneering study in The American Journal of Pathology, published by Elsevier, reveal that administration of the neuropeptide α-melanocyte-stimulating hormone (α-MSH) promotes corneal healing and restores normal eye function to an otherwise degenerating and diseased cornea by providing protection against cell death and promoting cell regeneration.

2 Jan 2024

Degron Therapeutics announced as winner of AFCR's 2023 BRACE Award Venture Competition

The Asian Fund for Cancer Research (AFCR) is pleased to announce that Degron Therapeutics was selected as the winner of the 2023 BRACE Award Venture Competition.

27 Dec 2023

Private equity takeovers linked to higher rates of patient harm in hospitals

Patients are more likely to fall, get new infections, or experience other forms of harm during their stay in a hospital after it is acquired by a private equity firm, according to a new study led by researchers at Harvard Medical School.

26 Dec 2023

New model links RNA editing glitch to early-stage type 1 diabetes

Hebrew University study proposes a new model suggesting that disrupted RNA editing within pancreatic beta cells might initiate an inflammatory response akin to early-stage type 1 diabetes.

26 Dec 2023

Examining two serum biomarkers as early predictors of cognitive decline in women

Researchers from the University of Michigan have connected two blood biomarkers to changes in cognitive function in women in midlife, opening a potentially powerful path to noninvasive, earlier detection and interventions for Alzheimer’s disease and other dementias.

21 Dec 2023

New models identify pregnant women at risk of missing crucial prenatal care

Socioeconomic factors, like education and location, can affect access to life-saving prenatal care services.

20 Dec 2023

How a malaria drug may hold the key to ending malnutrition's cycle of devastation

Wars, drought, displacement, and instability are causing a dramatic increase in the number of pregnant and breastfeeding women around the world who suffer from malnutrition.

20 Dec 2023

iWHELD training improves quality of life for dementia residents, study finds

Quality of life for people with dementia living in residential and nursing home care substantially improved after staff took part in a digital training programme that was specially adapted to Covid-19 restrictions.

20 Dec 2023

Widespread cannabis use linked to increase in psychiatric disorders, UMSOM review finds

The widespread use of cannabis (marijuana) and its increased potency are associated with a rise in cannabis-related psychiatric conditions, according to a new University of Maryland School of Medicine (UMSOM) review article that was recently published in the New England Journal of Medicine.

19 Dec 2023

Study: Depression, anxiety and PTSD common among caregivers of severe stroke survivors

Stroke is an abrupt, devastating disease that instantly changes a person's life and has the potentially to cause lasting disability or death. However, the condition also has profound effects on the patient's loved ones - who are often called to make difficult decisions quickly.

19 Dec 2023

Autopsy study provides new insights into yellow fever's impact on the heart

To fill gaps in knowledge of yellow fever (YF), a group of researchers in Brazil affiliated with the Department of Pathology at the University of São Paulo's Medical School (FM-USP), Hospital das Clínicas (HC, the hospital complex run by FM-USP), the Heart Institute (InCor, linked to HC) and Emílio Ribas Institute of Infectious Diseases (IIER) decided to study the pathogenesis of YF-associated heart injury.

19 Dec 2023

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

19 Dec 2023

First case of COVID-caused vocal cord paralysis in teen reported by Mass Eye and Ear doctors

Physician-researchers from Mass Eye and Ear, a member of Mass General Brigham, report the first pediatric case of bilateral vocal cord paralysis after COVID-19 (SARS-CoV-2) infection.

19 Dec 2023

Medical School News and Research

Missing proteins explain century-old mystery of scalp skin absence in children

Researchers uncover variations in how IBD affects people of different races, sexes and places of birth

New study demystifies clinicians' decision-making process for drug-drug interactions

New brain imaging technique sheds light on invisible mTBIs

MGH study identifies key proteins linked to pregnancy hypertension disorders

Existing beta blocker investigated as novel sickle cell therapy

Enlarged perivascular spaces in infancy associated with sleep problems and autism risk

Study identifies α-MSH as therapeutic candidate for corneal endothelial disease

Degron Therapeutics announced as winner of AFCR's 2023 BRACE Award Venture Competition

Private equity takeovers linked to higher rates of patient harm in hospitals

New model links RNA editing glitch to early-stage type 1 diabetes

Examining two serum biomarkers as early predictors of cognitive decline in women

New models identify pregnant women at risk of missing crucial prenatal care

How a malaria drug may hold the key to ending malnutrition's cycle of devastation

iWHELD training improves quality of life for dementia residents, study finds

Widespread cannabis use linked to increase in psychiatric disorders, UMSOM review finds

Study: Depression, anxiety and PTSD common among caregivers of severe stroke survivors

Autopsy study provides new insights into yellow fever's impact on the heart

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

First case of COVID-caused vocal cord paralysis in teen reported by Mass Eye and Ear doctors

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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