Genes News and Research

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Autism Speaks grants $2.7M to develop potential treatments for ASD, increase access to high-quality early intervention

Autism Speaks, the world's leading autism science and advocacy organization, today announced the award of nearly $2.7 million for the funding of 13 new research projects over the next three years.

6 Jan 2014

Johns Hopkins Kimmel Cancer Center scientists to receive $90M in new funding for cancer research

cientists at the Johns Hopkins Kimmel Cancer Center will receive $90 million in new funding as part of a $540 million gift from Ludwig Cancer Research, on behalf of its founder Daniel K. Ludwig, to six U.S. institutions. The new award is among the largest for a single private gift to cancer research.

6 Jan 2014

Editing of protein-making sequences promotes development of ESCC, find NUS researchers

Esophageal Squamous Cell Carcinoma, the major histological form of esophageal cancer, is the leading cause of cancer death worldwide. Scientists from the National University of Singapore have discovered a biomarker, called adenosine deaminase acting on RNA-1, which has the potential to improve the diagnosis, prognosis and treatment of this disease.

6 Jan 2014

Special publication details breakthrough research on causes of vascular disease

The world's leading voices in the fight against Pulmonary Hypertension have compiled a special publication detailing the breakthrough research into the causes of this debilitating vascular disease.

6 Jan 2014

Hopkins scientists design new mouse that mimics common form of leukemia

Johns Hopkins Kimmel Cancer Center investigators have genetically engineered a new mouse that mimics a common form of leukemia in humans. Studying the model could lead to new understanding of the disease, they say.

6 Jan 2014

Gene-based technology for effective weight loss solutions

Losing weight is the most popular New Year's resolution for 2014, but research shows that only eight percent of people are successful in achieving their resolutions.

6 Jan 2014

Researchers observe mating for the first time in microbes responsible for African sleeping sickness

Caught in the act! Researchers from the University of Bristol have observed mating for the first time in the microbes responsible for African sleeping sickness. This tropical disease is caused by trypanosomes, single-celled parasites that are found in the blood of those afflicted.

5 Jan 2014

Dysfunction in MADD gene in mice causes fasting hyperglycemia

Researchers from the University of Illinois at Chicago College of Medicine have found that dysfunction in a single gene in mice causes fasting hyperglycemia, one of the major symptoms of type 2 diabetes. Their findings were reported online in the journal Diabetes.

5 Jan 2014

AstraZeneca to take over Probiodrug's CDK9 inhibitor program

Probiodrug AG announced today the transfer of its experimental cyclin-dependent kinase 9 inhibitor program to AstraZeneca. The transaction includes the sale to AstraZeneca of a lead molecule and back-up compounds with the associated intellectual property. CDK9, which has been implicated in the transcriptional regulation of genes involved in proliferation and inflammation, is a promising target for the treatment of both cancer and inflammatory diseases.

3 Jan 2014

Discovery opens new pathways for treatment of toxoplasmosis and malaria

A newly identified protein and other proteins it interacts with could become effective targets for new drugs to control the parasite that cause toxoplasmosis, researchers led by investigators at Indiana University School of Medicine have reported.

3 Jan 2014

Study indicates that smoking disrupts circadian clock function in both lungs and brain

As if cancer, heart disease and other diseases were not enough motivation to make quitting smoking your New Year's resolution, here's another wake-up call: New research published in the January 2014 issue of The FASEB Journal suggests that smoking disrupts the circadian clock function in both the lungs and the brain.

3 Jan 2014

Study suggests that ROR1 could be an important therapeutic target for patients with CLL

Researchers at the University of California, San Diego School of Medicine report that an oncogene dubbed ROR1, found on chronic lymphocytic leukemia (CLL) B cells but not normal adult tissues, acts as an accelerant when combined with another oncogene, resulting in a faster-developing, more aggressive form of CLL in mice.

3 Jan 2014

Scientists discover new class of cells expressing olfactory receptors in human airways

Your nose is not the only organ in your body that can sense cigarette smoke wafting through the air. Scientists at Washington University in St. Louis and the University of Iowa have showed that your lungs have odor receptors as well.

3 Jan 2014

University of Utah discovers cellular mechanism that stops metastasis of breast cancer

Researchers from Huntsman Cancer Institute (HCI) at the University of Utah discovered a cellular mechanism that drives the spread of breast cancer to other parts of the body (metastasis), as well as a therapy which blocks that mechanism. The research results were published online in the journal Cell Reports on January 2.

3 Jan 2014

Study finds extraordinary link between narcolepsy and specific gene variant

A new study conducted across Europe found an extraordinary association between narcolepsy and a specific gene variant related to the immune system.

2 Jan 2014

Computer algorithm developed to identify genes that could be transformed to stop aging process

Restricting calorie consumption is one of the few proven ways to combat aging. Though the underlying mechanism is unknown, calorie restriction has been shown to prolong lifespan in yeast, worms, flies, monkeys, and, in some studies, humans.

2 Jan 2014

Researchers identify two novel BRAF fusions in melanomas

Stand Up To Cancer, the charitable initiative supporting ground-breaking research aimed at getting new cancer treatments to patients in an accelerated timeframe, announces that Jeffrey A. Sosman, M.D., a Stand Up To Cancer Melanoma Dream Team investigator, William Pao, M.D., Ph.D., a 2009 Stand Up To Cancer Innovative Research Grant recipient and colleagues identified two novel BRAF fusions in melanomas previously considered to be negative for molecular targets, and that melanomas with these fusions were found to be potentially sensitive to anticancer drugs called MEK inhibitors, according to a study recently published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

2 Jan 2014

Innovative therapy offers new hope to breast cancer patients

A novel breast-cancer therapy that partially reverses the cancerous state in cultured breast tumor cells and prevents cancer development in mice, could one day provide a new way to treat early stages of the disease without resorting to surgery, chemotherapy or radiation, a multi-institutional team led by researchers from the Wyss Institute of Biologically Inspired Engineering at Harvard University reported January 1 in Science Translational Medicine.

2 Jan 2014

Scientists obtain detailed molecular structure of member of Tet family of enzymes

Scientists have obtained the first detailed molecular structure of a member of the Tet family of enzymes.

28 Dec 2013

Cells' adaptations to low oxygen conditions inside tumors promote breast cancer's spread

Biologists at The Johns Hopkins University have discovered that low oxygen conditions, which often persist inside tumors, are sufficient to initiate a molecular chain of events that transforms breast cancer cells from being rigid and stationery to mobile and invasive.

27 Dec 2013

Genes News and Research

Autism Speaks grants $2.7M to develop potential treatments for ASD, increase access to high-quality early intervention

Johns Hopkins Kimmel Cancer Center scientists to receive $90M in new funding for cancer research

Editing of protein-making sequences promotes development of ESCC, find NUS researchers

Special publication details breakthrough research on causes of vascular disease

Hopkins scientists design new mouse that mimics common form of leukemia

Gene-based technology for effective weight loss solutions

Researchers observe mating for the first time in microbes responsible for African sleeping sickness

Dysfunction in MADD gene in mice causes fasting hyperglycemia

AstraZeneca to take over Probiodrug's CDK9 inhibitor program

Discovery opens new pathways for treatment of toxoplasmosis and malaria

Study indicates that smoking disrupts circadian clock function in both lungs and brain

Study suggests that ROR1 could be an important therapeutic target for patients with CLL

Scientists discover new class of cells expressing olfactory receptors in human airways

University of Utah discovers cellular mechanism that stops metastasis of breast cancer

Study finds extraordinary link between narcolepsy and specific gene variant

Computer algorithm developed to identify genes that could be transformed to stop aging process

Researchers identify two novel BRAF fusions in melanomas

Innovative therapy offers new hope to breast cancer patients

Scientists obtain detailed molecular structure of member of Tet family of enzymes

Cells' adaptations to low oxygen conditions inside tumors promote breast cancer's spread

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