Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Protease inhibition could help defeat SARS-CoV-2

As the COVID-19 pandemic caused by the coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to spread around the world, many researchers are studying epidemiological models to predict its propagation. As of yet, there are no effective vaccines that could counter the SARS- CoV-2 infection or drugs to treat COVID-19 disease

9 Jun 2020

A new strategy to combat influenza A and Zika virus

Leuven researchers have deployed synthetic amyloids to trigger protein misfolding as a strategy to combat the influenza A and Zika virus.

9 Jun 2020

New technique to identify genes implicated in the development of malignant brain tumor

Researchers at Uppsala University have developed a method for identifying functional mutations and their effect on genes relevant to the development of glioblastoma - a malignant brain tumor with a very poor prognosis. The study is published in Genome Biology.

9 Jun 2020

Avacta provides update on COVID-19 antigen diagnostic test development with Adeptrix

Avacta Group plc is pleased to announce that a BAMS™ diagnostic test for COVID-19, being developed with Adeptrix, has reached the prototype stage.

From Avacta Life Sciences Ltd. 9 Jun 2020

Anti-RBD antibodies shown to neutralize active SARS-CoV-2

A new study published on the preprint server bioRxiv* in June 2020 reports the discovery of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in samples from healthy donors, collected before the pandemic. These antibodies are capable of inhibiting the binding of the spike protein of the virus to the angiotensin-converting enzyme 2 (ACE2) molecule and can neutralize active infection of cells in culture.

9 Jun 2020

COVID-19 produces lung inflammation in non-human primate experiments

A new study published on the online preprint server bioRxiv in June 2020 reports the successful use of three primate species to model the infection, pathogenesis, and clinical features associated with COVID-19. The research provides useful and immediately available models to test new vaccines and treatments.

9 Jun 2020

Metabolic diseases alter ACE2 expression and increase COVID-19 severity

A new study published on the preprint server medRxiv in June 2020 reports that one mechanism for this variable severity is the differential expression of the ACE2 receptor in various metabolic conditions, thereby facilitating viral entry into the host cells.

9 Jun 2020

Scientists harness cancer immunotherapy tools to identify targets for COVID-19 vaccine

Cancer researchers at Children's Hospital of Philadelphia have harnessed tools used for the development of cancer immunotherapies and adapted them to identify regions of the SARS-CoV-2 virus to target with a vaccine, employing the same approach used to elicit an immune response against cancer cells to stimulate an immune response against the virus.

8 Jun 2020

New Canadian study investigates how cancer adapts its metabolism to overcome therapies

Knowing what cancer will do next could lessen the likelihood of it becoming resistant to treatment. A new Canadian study investigates how cancer adapts its metabolism to potentially overcome therapies still in development.

8 Jun 2020

Census of viral spike protein antigens could benefit development of SARS-CoV-2 therapeutics

A group of researchers has determined how different proteins associated with SARS-CoV-2 - the virus that causes COVID-19 - generate immune responses when given to rabbits as immunizations.

8 Jun 2020

Health disparities negatively impact various groups of people

Certain illnesses and diseases have the ability to affect various groups of people in detrimental ways.

8 Jun 2020

Chemotherapy and cancer join together to cause neuropathy

Contrary to common medical guidance, chemotherapy does not appear to be the only culprit in neuropathy, a neurological side effect of cancer treatment, a new study says. Cancer itself contributes heavily, too, and the stresses on neurons appear far worse than the sum of the two causes.

8 Jun 2020

Innovative algorithm helps select patients in need of urgent surgery or chemotherapy during COVID-19

A new approach to better select breast cancer patients in need of urgent surgery or chemotherapy during the COVID-19 pandemic has been developed by researchers at The Royal Marsden and the Breast Cancer Now Research Centre at The Institute of Cancer Research, London, in collaboration with colleagues in the UK, Germany and US.

8 Jun 2020

Research team identifies key ingredients for producing high-value chemical compounds

Researchers have identified key ingredients for producing high-value chemical compounds in an environmentally friendly fashion: repurposed enzymes, curiosity, and a little bit of light.

8 Jun 2020

Synthetic monoclonal antibodies effectively neutralize SARS-CoV-2 in laboratory conditions

In a new study available on the preprint server bioRxiv*, a multinational research group demonstrated how monoclonal antibodies strongly inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro at even sub-nanomolar concentrations. This makes them a prime candidate for the treatment of coronavirus disease (COVID-19).

8 Jun 2020

SARS-CoV-2 infection causes specific kidney proximal tubular injury

SARS-CoV-2-associated acute kidney injury (AKI) is one of the more frequently encountered organ involvements in COVID-19 - in as many as 80% of critically ill patients, according to a recent study.

8 Jun 2020

New EUbOPEN consortium will enable access to research tools to unlock disease biology

Frankfurt and Ingelheim. Almost twenty years after deciphering the human genome, our understanding of human disease is still far from complete.

8 Jun 2020

Incidence of intracerebral hemorrhages increasing in older people, study finds

Brain bleeds called intracerebral hemorrhages remained stable in incidence among all age groups over the past 30 years, but they increased in people 75 and older, according to a new analysis of the Framingham Heart Study. The findings are in JAMA Neurology.

8 Jun 2020

Acute kidney injury in intensive-care COVID-19 patients

71 patients with severe lung injury were admitted to four intensive care units at Bordeaux University Hospital and their data were collected and evaluated over a period of six weeks (March/April 2020). AKI was defined using KDIGO criteria and ADQI according to the Acute Disease Quality Initiative (ADQI) 16 workgroup.

8 Jun 2020

Study uncovers link between psoriasis and joint disease

A team led by Case Western Reserve University School of Medicine researchers has made two major discoveries involving psoriasis, a chronic and debilitating skin disease with no known cure.

8 Jun 2020

Protein News and Research

Further Reading

Protease inhibition could help defeat SARS-CoV-2

A new strategy to combat influenza A and Zika virus

New technique to identify genes implicated in the development of malignant brain tumor

Avacta provides update on COVID-19 antigen diagnostic test development with Adeptrix

Anti-RBD antibodies shown to neutralize active SARS-CoV-2

COVID-19 produces lung inflammation in non-human primate experiments

Metabolic diseases alter ACE2 expression and increase COVID-19 severity

Scientists harness cancer immunotherapy tools to identify targets for COVID-19 vaccine

New Canadian study investigates how cancer adapts its metabolism to overcome therapies

Census of viral spike protein antigens could benefit development of SARS-CoV-2 therapeutics

Health disparities negatively impact various groups of people

Chemotherapy and cancer join together to cause neuropathy

Innovative algorithm helps select patients in need of urgent surgery or chemotherapy during COVID-19

Research team identifies key ingredients for producing high-value chemical compounds

Synthetic monoclonal antibodies effectively neutralize SARS-CoV-2 in laboratory conditions

SARS-CoV-2 infection causes specific kidney proximal tubular injury

New EUbOPEN consortium will enable access to research tools to unlock disease biology

Incidence of intracerebral hemorrhages increasing in older people, study finds

Acute kidney injury in intensive-care COVID-19 patients

Study uncovers link between psoriasis and joint disease

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