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New research evaluating substantial disease burden of PNH presented at European Hematology Association

Alexion Pharmaceuticals, Inc. today announced new research evaluating the substantial disease burden of paroxysmal nocturnal hemoglobinuria, an ultra-rare blood disorder, in patients worldwide. The International PNH Registry, involving 580 patients from 99 sites in 14 countries as of May 2010, found that the debilitating symptoms and life-threatening complications of PNH are similar across patient populations around the world.

14 Jun 2010

Study finds survival disparities among patients with colorectal cancer

Disparities in cancer stage and treatment are the main reasons why Medicaid-insured and uninsured rectal cancer patients are twice as likely to die within five years as privately insured patients. That is the conclusion of a new study published early online in Cancer, a peer-reviewed journal of the American Cancer Society. Because poorer survival among rectal cancer patients without private insurance is largely attributable to later cancer stage at diagnosis and inadequate treatment, disparities may be lessened through health care reform.

14 Jun 2010

Nexavar does not meet primary endpoint in Phase 3 NExUS trial for advanced NSCLC

Bayer HealthCare Pharmaceuticals and Onyx Pharmaceuticals, Inc. today announced that the final analysis of the Phase 3 NExUS (NSCLC research Experience Utilizing Sorafenib) trial evaluating Nexavar® (sorafenib) tablets in patients with advanced non-squamous non-small cell lung cancer (NSCLC) showed that the study did not meet its primary endpoint of improving overall survival in the first-line setting.

14 Jun 2010

Homeless Brisbane population at risk of dying early: survey

A recent survey has shown that more than 50 percent of Brisbane’s homeless community is at a higher risk of early deaths. The survey was conducted by interviewing at least 231 people who live on Brisbane's streets, using an index to determine their risk of dying or mortality risk.

14 Jun 2010

PolyMedix awarded $150,000 grant to support development of antimicrobial sutures to reduce SSIs

A new discovery may help curb surgical site infections through the use of a novel antibiotic agent that can be incorporated into sutures. SSIs are the third most common hospital-acquired infection and may be associated with severe morbidity and mortality. Since more than 60% of SSIs occur in the area of the incision, the use of sutures coated with an antibacterial agent called PolyCides, created by Radnor, PA-based PolyMedix Inc., may reduce infection rates.

14 Jun 2010

Study: Children with idiopathic onset epilepsy have high remission rate

A study conducted by researchers in The Netherlands confirmed that children with idiopathic new-onset epilepsy have a significantly higher rate of remission than those with remote symptomatic epilepsy.

14 Jun 2010

Chiasma successfully completes Phase I clinical study of Octreolin

Chiasma, Inc., a privately held biopharma company, announced that it has successfully completed a Phase I clinical study evaluating the safety and pharmacokinetics (PK) of its proprietary product Octreolin, which contains the active ingredient octreotide actetate and is administered orally

14 Jun 2010

Trauma patients without insurance more likely to die of injuries than privately insured patients: Study

Trauma patients without insurance are more likely to die of their injuries from auto accidents and gunshot wounds than privately insured patients with similar injuries, according to findings of an analysis of 193,804 patients from 649 facilities conducted by University Buffalo emergency medicine physicians.

14 Jun 2010

Community-based model of DOT improves HIV patient survival: Researchers

When applied to HIV care, the community-based model of directly observed therapy has no effect on virologic outcomes, but significantly improves patient survival. This is according to researchers at the Johns Hopkins Bloomberg School of Public Health, in collaboration with colleagues at University of Cape Town, South Africa, who conducted the first randomized controlled trial of patient-nominated treatment-supporters providing partial DOT in resource-limited settings.

11 Jun 2010

Boston Scientific announces event schedule at 17th Cardiostim World Congress

Boston Scientific Corporation today announced the schedule of the Company's key events and sponsored research at the 17th Cardiostim World Congress, June 16 – 19 in Nice, France.

11 Jun 2010

Phase 2b RESTORE-CLI clinical trial in patients with CLI reaches statistical significance

Richard J. Powell, M.D., section chief of vascular surgery at the Dartmouth-Hitchcock Medical Center in Lebanon, NH and a principal investigator of the U.S. Phase 2b RESTORE-CLI clinical trial sponsored by Aastrom Biosciences, will present the full results from the interim analysis at today's session of the annual meeting of the Society for Vascular Surgery.

11 Jun 2010

Dabigatran Etexilate anticoagulant as effective as Enoxaparin in preventing venous thromboembolism

Data from the RE-NOVATE® II study presented today at the 15th Annual Congress of the European Hematology Association (EHA) have shown that dabigatran etexilate 220mg once daily is as effective and safe as enoxaparin 40mg in preventing venous thromboembolism (VTE) after total hip replacement surgery.

11 Jun 2010

New study data on distal aortic perfusion for thoracoabdominal aortic aneurysm repair

The vascular surgeons at Massachusetts General Hospital (MGH) in Boston have traditionally repaired thoracoabdominal aortic aneurysms (TAA) with a clamp and sew (CS) technique that includes neuro-protective adjuncts like epidural cooling and aggressive intercostal reconstruction (IC) to prevent spinal cord ischemia.

11 Jun 2010

Protein IL-10 removes Escherichia coli K1 bacterium from blood and reverses brain damage

A team of researchers at Childrens Hospital Los Angeles (CHLA), along with colleagues from the Keck School of Medicine of the University of Southern California and the Universite Auvergne, France, have discovered an important role for a small, naturally occurring protein called interleukin-10 (IL-10) in removing bacteria from the blood of infected mice and reversing damage to the brain.

11 Jun 2010

New book provides overview of paediatric drug development

Children in the developed world have never enjoyed better medical care: mortality has decreased and many fatal diseases of the past can today be prevented or even cured. However, the current practice of pharmacotherapy in children does not reflect existing scientific knowledge and has come under scrutiny by paediatricians, pharmacists and regulatory authorities. In order to advance the development of medicines tailored to paediatric needs, US and EU legislators have taken action, and the WHO has initiated a global paediatric campaign.

11 Jun 2010

Women Deliver conference concludes

The Women Deliver conference concluded on Wednesday, as attendees "celebrated benchmark achievements in reducing maternal and infant mortality and faced stubborn failures at the same time," Womens eNews reports.

11 Jun 2010

Investigative Workshop aims to discuss current achievements, challenges in modeling solid tumors

With high human mortality associated with cancerous tumors, there is a worldwide need for a better understanding of why a tumor starts to grow and what makes it continue to grow. Mathematical modeling can provide some of the answers.

10 Jun 2010

Ipsilateral PVI failure in patients with CLI predicts poor outcome after LEB: Study

Prior failed ipsilateral percutaneous vascular intervention in patients with critical limb ischemia predicts poor outcome after lower extremity bypass, according to a study from the 64th Vascular Annual Meeting presented by the Society for Vascular Surgery.

10 Jun 2010

Study reveals insurance related differences in hospital mortality for AMI, stroke, pneumonia

An analysis of over 150,000 hospital discharges has revealed that there are significant insurance related differences in hospital mortality, length of stay, and costs among working-age Americans (age 18-64 years) hospitalized for acute myocardial infarction (AMI), stroke, or pneumonia. These three conditions are among the leading causes of non-cancer in-patient deaths in patients under 65 years old. The analysis is published today in the Journal of Hospital Medicine.

10 Jun 2010

Number of Medicare patients transferred to long-term acute care hospital after critical illness tripled: JAMA

From 1997 to 2006, the number of long-term acute care hospitals doubled, the number of Medicare patients who were transferred to a long-term acute care hospital after a critical illness tripled, and the 1 year survival for these patients was poor, according to a study in the June 9 issue of JAMA.

10 Jun 2010

Mortality News and Research

New research evaluating substantial disease burden of PNH presented at European Hematology Association

Study finds survival disparities among patients with colorectal cancer

Nexavar does not meet primary endpoint in Phase 3 NExUS trial for advanced NSCLC

Homeless Brisbane population at risk of dying early: survey

PolyMedix awarded $150,000 grant to support development of antimicrobial sutures to reduce SSIs

Study: Children with idiopathic onset epilepsy have high remission rate

Chiasma successfully completes Phase I clinical study of Octreolin

Trauma patients without insurance more likely to die of injuries than privately insured patients: Study

Community-based model of DOT improves HIV patient survival: Researchers

Boston Scientific announces event schedule at 17th Cardiostim World Congress

Phase 2b RESTORE-CLI clinical trial in patients with CLI reaches statistical significance

Dabigatran Etexilate anticoagulant as effective as Enoxaparin in preventing venous thromboembolism

New study data on distal aortic perfusion for thoracoabdominal aortic aneurysm repair

Protein IL-10 removes Escherichia coli K1 bacterium from blood and reverses brain damage

New book provides overview of paediatric drug development

Women Deliver conference concludes

Investigative Workshop aims to discuss current achievements, challenges in modeling solid tumors

Ipsilateral PVI failure in patients with CLI predicts poor outcome after LEB: Study

Study reveals insurance related differences in hospital mortality for AMI, stroke, pneumonia

Number of Medicare patients transferred to long-term acute care hospital after critical illness tripled: JAMA

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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