Genes News and Research

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Coding variants in immune disease-related genes play only small part in risk for psoriasis

Coding variants in immune disease-related genes play only a small part in the overall genetic risk for psoriasis, according to a new study led by Anhui Medical University and BGI.

10 Nov 2013

Breast cancer drug appears to protect cells against UV radiation, inflammation

Exemestane, a synthetic steroid drug widely prescribed to fight breast cancers that thrive on estrogens, not only inhibits the production of the hormone, but also appears to protect cells throughout the body against damage induced by UV radiation, inflammation and other assaults, according to results of research by Johns Hopkins scientists.

8 Nov 2013

Gladstone-led study sheds light on critical molecular process

One of biology's most fundamental processes is something called transcription. It is just one step of many required to build proteins-and without it life would not exist. However, many aspects of transcription remain shrouded in mystery. But now, scientists at the Gladstone Institutes are shedding light on key aspects of transcription, and in so doing are coming even closer to understanding the importance of this process in the growth and development of cells-as well as what happens when this process goes awry.

8 Nov 2013

Discovery could rev up body's immune response to infection, autoimmune diseases

UT Southwestern Medical Center researchers report that disrupting the light-dark cycle of mice increased their susceptibility to inflammatory disease, indicating that the production of a key immune cell is controlled by the body's circadian clock.

8 Nov 2013

Cholesterol metabolite promotes tumor growth in breast cancers

A team of researchers at UT Southwestern has found that as cholesterol is metabolized, a potent stimulant of breast cancer is created - one that fuels estrogen-receptor positive breast cancers, and that may also defeat a common treatment strategy for those cancers.

8 Nov 2013

Brain & Behavior Research Foundation announces recipients of NARSAD Investigator Grants

The Brain & Behavior Research Foundation (formerly known as NARSAD, the National Alliance for Research on Schizophrenia and Depression), under the direction of Dr. Jeffrey Borenstein, President & CEO, has announced the latest recipients of its NARSAD Distinguished Investigator Grants.

8 Nov 2013

Researchers identify chain reaction that triggers regrowth of some damaged nerve cell

Researchers at Washington University School of Medicine in St. Louis have identified a chain reaction that triggers the regrowth of some damaged nerve cell branches, a discovery that one day may help improve treatments for nerve injuries that can cause loss of sensation or paralysis.

8 Nov 2013

Researchers able to regrow bone, hair, soft tissues and cartilage in mouse model

Young animals are known to repair their tissues effortlessly, but can this capacity be recaptured in adults? A new study from researchers at the Stem Cell Program at Boston Children's Hospital suggests that it can. By reactivating a dormant gene called Lin28a, which is active in embryonic stem cells, researchers were able to regrow hair and repair cartilage, bone, skin and other soft tissues in a mouse model.

8 Nov 2013

Lowa researchers create bio patch that regenerates missing or damaged bone

Researchers at the University of Iowa have created a bio patch to regenerate missing or damaged bone by putting DNA into a nano-sized particle that delivers bone-producing instructions directly into cells.

8 Nov 2013

Researchers identify enzymes that are crucial for growth of cancers with genetic aberrations in p53

The most frequently mutated gene across all types of cancers is a gene called p53. Unfortunately it has been difficult to directly target this gene with drugs. Now a multi-institutional research team, led by Dr. Lewis Cantley and investigators at Weill Cornell Medical College, has identified a family of enzymes they say is crucial for the growth of cancers that have genetic aberrations in p53.

8 Nov 2013

Diets and the famine reaction: an interview with Associate Professor Amanda Salis, University of Sydney

The statistic that you often hear is that 95% of diets fail, but in actual fact, emerging research is now showing that it’s around 70% of diets that fail. That means that around 30% of people who are losing weight are actually keeping it off. So we’re doing better now than we were doing in the past, but there’s still work to be done.

7 Nov 2013

Researchers identify markers of social disability in 2 to 6-month-old infants

Researchers at Marcus Autism Center, Children's Healthcare of Atlanta and Emory University School of Medicine have identified signs of autism present in the first months of life.

7 Nov 2013

New study could help lead to prevention and treatment of heart failure in diabetics

Researchers from the University of Texas Medical Branch at Galveston have discovered one of the pathogenic components of diabetes in the heart, as published in the Journal of Biological Chemistry.

7 Nov 2013

Research: Chronic stress changes gene activity in immune cells before reaching bloodstream

New research shows that chronic stress changes gene activity in immune cells before they reach the bloodstream. With these changes, the cells are primed to fight an infection or trauma that doesn't actually exist, leading to an overabundance of the inflammation that is linked to many health problems.

6 Nov 2013

Gene mutated in rare hereditary disorder also prevents mTORC1 pathway activation

Whitehead Institute scientists report that the gene mutated in the rare hereditary disorder known as Birt-Hogg-Dub- cancer syndrome also prevents activation of mTORC1, a critical nutrient-sensing and growth-regulating cellular pathway.

5 Nov 2013

Research findings could offer new insights into how defective cells can multiply in diseases

A rudimentary form of life that is found in some of the harshest environments on earth is able to sidestep normal replication processes and reproduce by the back door, researchers at The University of Nottingham have found.

5 Nov 2013

Researchers identify factor that promotes metastasis of colon tumors

Tumors become highly malignant when they acquire the ability to colonize other tissues and form metastases. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have identified a factor that promotes metastasis of colon tumors - and presents a possible target for therapy.

5 Nov 2013

Computer-aided image analysis provides "second opinion" to identify breast tumor

Researchers at the University of Chicago are developing computer-aided diagnosis (CADx) and quantitative image analysis (QIA) methods for mammograms, ultrasounds and magnetic resonance images (MRIs) to identify specific tumor characteristics, including size, shape and sharpness, said lead researcher Maryellen Giger, A.N. Pritzker Professor of Radiology/Medical Physics and director of the Imaging Research Institute at the University of Chicago.

5 Nov 2013

Researchers find crucial step in determining normal aging

For the first time in a large study sample, the decline in brain function in normal aging is conclusively shown to be influenced by genes, say researchers from the Texas Biomedical Research Institute in San Antonio and Yale University.

4 Nov 2013

LMU researchers identify a factor that promotes metastasis of colon tumors

Tumors become highly malignant when they acquire the ability to colonize other tissues and form metastases. Researchers at Ludwig-Maximilians-Universitaet in Munich have identified a factor that promotes metastasis of colon tumors - and presents a possible target for therapy.

4 Nov 2013

Genes News and Research

Coding variants in immune disease-related genes play only small part in risk for psoriasis

Breast cancer drug appears to protect cells against UV radiation, inflammation

Gladstone-led study sheds light on critical molecular process

Discovery could rev up body's immune response to infection, autoimmune diseases

Cholesterol metabolite promotes tumor growth in breast cancers

Brain & Behavior Research Foundation announces recipients of NARSAD Investigator Grants

Researchers identify chain reaction that triggers regrowth of some damaged nerve cell

Researchers able to regrow bone, hair, soft tissues and cartilage in mouse model

Lowa researchers create bio patch that regenerates missing or damaged bone

Researchers identify enzymes that are crucial for growth of cancers with genetic aberrations in p53

Diets and the famine reaction: an interview with Associate Professor Amanda Salis, University of Sydney

Researchers identify markers of social disability in 2 to 6-month-old infants

New study could help lead to prevention and treatment of heart failure in diabetics

Research: Chronic stress changes gene activity in immune cells before reaching bloodstream

Gene mutated in rare hereditary disorder also prevents mTORC1 pathway activation

Research findings could offer new insights into how defective cells can multiply in diseases

Researchers identify factor that promotes metastasis of colon tumors

Computer-aided image analysis provides "second opinion" to identify breast tumor

Researchers find crucial step in determining normal aging

LMU researchers identify a factor that promotes metastasis of colon tumors

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