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Neuroscientists track gene expression to gain insights into drug addiction, Parkinson's disease

Two MIT neuroscientists have received grants from the G. Harold and Leila Y. Mathers Foundation to screen for genes that could help brain cells withstand Parkinson's disease and to map how gene expression changes in the brain in response to drugs of abuse.

4 Jan 2021

Epigenetic modulators have a rapid antidepressant-like effect, study shows

Treatment of depression faces two main challenges. The first is that almost 50% of patients do not respond well to existing antidepressants.

4 Jan 2021

Study clarifies the effect of aging on hematopoietic stem cells

By transferring mouse aged hematopoietic stem cells (aged HSCs) to the environment of young mice (bone marrow niche), it was demonstrated that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells.

24 Dec 2020

Could engineered red blood cells be an effective antiviral against SARS-CoV-2?

In a new study, released on the bioRxiv* preprint server, a team of researchers explores the antiviral potential of red blood cells against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19.

24 Dec 2020

Researchers discover protein that adjusts gene activity to match nutrient levels in roundworms

Transforming a fertilized egg into a fully functional adult is a complicated task. Cells must divide, move, and mature at specific times. Developmental genes control that process, turning on and off in a choreographed way.

23 Dec 2020

Transcription factors in the brain strongly correlate with the behavior of honey bees

An unusual study that involved bar coding and tracking the behavior of thousands of individual honey bees in six queenless bee hives and analyzing gene expression in their brains offers new insights into how gene regulation contributes to social behavior.

23 Dec 2020

New drug starves cancer cells by attacking mitochondria

A newly developed compound starves cancer cells by attacking their "power plants" - the so-called mitochondria.

22 Dec 2020

Anti-diarrhea drug triggers cell death in glioblastoma cells

In cell culture, loperamide, a drug commonly used against diarrhea, proves effective against glioblastoma cells. A research team at Goethe University has now unraveled the drug’s mechanisms of action of cell death induction and – in doing so – has shown how this compound could help attack brain tumors that otherwise are difficult to treat.

22 Dec 2020

Researchers detect novel IRAK4 mutations in infant with encephalitis and HHV6 reactivation

An infant's odd case of rare encephalitis not typically found in children led researchers to discover never before seen genetic mutations and a more accurate technique to examine the IRAK4 gene responsible for innate immunity.

22 Dec 2020

Study highlights the far-reaching effects of mutagenic compounds on human health

In order to survive, flourish and successfully reproduce, organisms rely on a high degree of genetic stability. Mutagenic agents, which can threaten the integrity of the genetic code by causing mutations in DNA, pose a serious risk to human health.

21 Dec 2020

Pooled COVID-19 testing methods could detect outbreaks in schools, says study

A team of researchers at Tufts University, USA, has found that pool testing in schools and universities can identify COVID-19 patients. This way, schools can immediately report the case, refer the staff to health departments, and conduct contact tracing.

21 Dec 2020

Research may lead to better treatment and vaccines for Ebola, COVID-19

In the midst of a global pandemic with COVID-19, it's hard to appreciate how lucky those outside of Africa have been to avoid the deadly Ebola virus disease.

21 Dec 2020

Researchers identify novel mechanism by which CREB3L3 protein protects against atherosclerosis

Researchers from the University of Tsukuba identify a novel mechanism by which the protein CREB3L3 protects against atherosclerosis.

21 Dec 2020

Researchers discover more accurate technique to study gene responsible for innate immunity

20 Dec 2020

AOAC INTERNATIONAL issues Certificates of Validation for three test kits that detect SARS-CoV-2

AOAC INTERNATIONAL announced today that it has issued Certificates of Validation for three proprietary test kits that detect SARS-CoV-2, the causative agent of COVID-19 illness, on environmental surfaces.

18 Dec 2020

Higher COVID-19 mortality among certain groups in Colombia linked to structural inequalities

Researchers at the Ministry of Health and Social Protection in Bogotá, Colombia, provided evidence of socioeconomic inequalities in COVID-19 deaths in terms of age, sex, ethnicity, type of health insurance regime, and socioeconomic status.

18 Dec 2020

Study reveals innovative gene therapy approach to regenerate functional new neurons

Spinal cord injury (SCI) often causes disability and seriously compromises quality of life. While decades of research have made significant progress in axonal regeneration after SCI, most of the interventions have not been translated into clinical therapies.

18 Dec 2020

Transcription News and Research

Neuroscientists track gene expression to gain insights into drug addiction, Parkinson's disease

Epigenetic modulators have a rapid antidepressant-like effect, study shows

Study clarifies the effect of aging on hematopoietic stem cells

Could engineered red blood cells be an effective antiviral against SARS-CoV-2?

Researchers discover protein that adjusts gene activity to match nutrient levels in roundworms

Transcription factors in the brain strongly correlate with the behavior of honey bees

New drug starves cancer cells by attacking mitochondria

Anti-diarrhea drug triggers cell death in glioblastoma cells

Researchers detect novel IRAK4 mutations in infant with encephalitis and HHV6 reactivation

Study highlights the far-reaching effects of mutagenic compounds on human health

Pooled COVID-19 testing methods could detect outbreaks in schools, says study

Research may lead to better treatment and vaccines for Ebola, COVID-19

Researchers identify novel mechanism by which CREB3L3 protein protects against atherosclerosis

Researchers discover more accurate technique to study gene responsible for innate immunity

AOAC INTERNATIONAL issues Certificates of Validation for three test kits that detect SARS-CoV-2

Higher COVID-19 mortality among certain groups in Colombia linked to structural inequalities

Study reveals innovative gene therapy approach to regenerate functional new neurons

Study shows an inflammatory response in the mice brain is responsible for severe COVID-19

Why are some groups more vulnerable to COVID-19?

Researchers explain the role of enzyme that facilitates appropriate development of mouse embryo

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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