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Efficacy of polymeric nano-micelles depends on expression level of c-Myc

The Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki in Japan, Abbreviation: iCONM) reported in ACS Nano (Impact Factor: 14.588 in 2019) together with the group of Prof. Yu Matsumoto of Otorhinolaryngology and Head and Neck Surgery (Prof. Tatsuya Yamasoba) and the group of Prof. Horacio Cabral of the Department of Bioengineering (Prof. Ryo Miyake) in the University of Tokyo that the efficacy of polymeric nano-micelles with different drug activation profile depends on the expression level of c-Myc, one of the major proto-oncogene, has been developed.

27 Feb 2021

MicroRNAs predict heart and kidney health in children without disease

Molecules called microRNAs (miRNAs) that are measurable in urine have been identified by researchers at Mount Sinai as predictors of both heart and kidney health in children without disease.

27 Feb 2021

Newly identified genes increase risk of obesity and also protect against this disease

People living with obesity tend to have unhealthy glucose and lipid levels in their blood, as well as high blood pressure.

27 Feb 2021

Diverse patient population helps identify gene variant associated with childhood asthma

Researchers at Henry Ford Health System, as part of a national asthma collaborative, have identified a gene variant associated with childhood asthma that underscores the importance of including diverse patient populations in research studies.

27 Feb 2021

Atherosclerosis can speed up the development of clonal hematopoiesis

Billions of peripheral white blood cells are produced every day by the regular divisions of hematopoietic stem cells and their descendants in the bone marrow.

27 Feb 2021

Study: Heart problems cause disturbed gene activity in the brain's memory center

Heart problems cause disturbed gene activity in the brain's memory center, from which cognitive deficits arise.

27 Feb 2021

Neanderthal-derived protein may protect against COVID-19 susceptibility and severity

Researchers at the Lady Davis Institute at the Jewish General Hospital have discovered that increased levels of the protein OAS1 are associated with reduced mortality and less severe disease requiring ventilation among patients with COVID-19.

26 Feb 2021

Biomarkers in the blood can predict severe outcomes in COVID-19 patients

When patients with COVID-19 arrive in emergency rooms, there are relatively few ways for doctors to predict which ones are more likely to become critically ill and require intensive care and which ones are more likely to enjoy a quick recovery.

26 Feb 2021

NLRP3 inflammasome inhibitors may help treat early COVID-19, says study

A new study by researchers in the U.S. further supports the hypothesis that the unregulated release of inflammatory cytokines is responsible for the local and systemic inflammation that is associated with multi-organ damage and death in severe COVID-19.

26 Feb 2021

FDA permits marketing of new device to protect athletes from harmful effects of head impacts

Today, the U.S. Food and Drug Administration authorized marketing of a new device intended to be worn around the neck of athletes aged 13 years and older during sports activities to aid in the protection of the brain from the effects associated with repetitive sub-concussive head impacts.

26 Feb 2021

Structure of SARS-CoV-2 envelope protein-epithelial cell junction protein complex explains virulence

A new study by researchers at Brookhaven National Laboratory and Stony Brook University in the U.S. describes the key interaction between the viral envelope (E) protein and the human cell junction protein, PALS1. The latter is necessary to establish and maintain cell polarity and tight junctions between cells.

26 Feb 2021

Inhalable nanobody shows potent anti-SARS-CoV-2 activity in vivo

Researchers have developed a stable and ultrapotent homotrimeric Pittsburgh inhalable Nanobody 21 (PiN-21) against SARS-CoV-2 infection in Syrian hamsters. They demonstrated the high therapeutic efficacy of this homotrimeric Nb, leveraging both intranasal and aerosol delivery.

26 Feb 2021

Single dose of Pfizer BioNTech vaccine can reduce asymptomatic SARS-CoV-2 infections

New data from Addenbrooke's Hospital in Cambridge suggests that a single dose of the Pfizer BioNTech vaccine can reduce by four-fold the number of asymptomatic SARS-CoV-2 infections.

26 Feb 2021

Is one dose of Pfizer-BioNTech mRNA vaccine for COVID-19 convalescents sufficient?

Researchers evaluated the immune response in a cohort of 1,089 healthcare workers who received the Pfizer-BioNTech vaccine in Southern California.

26 Feb 2021

Biden’s straight-talking CDC director has long used data to save lives

In early December, Dr. Katy Stephenson was watching TV with her family and scrolling through Twitter when she saw a tweet that made her shout.

26 Feb 2021

New tool predicts trends and outcomes in individual patients

Clinical research requires that data be mined for insights. Machine learning, which develops algorithms to find patterns, has difficulty doing this with data related to health records because this type of information is neither static nor regularly collected.

26 Feb 2021

New approach can help treat hypertrophic cardiomyopathy with precision medicine

Hypertrophic cardiomyopathy (HCM) is a cardiovascular disease characterized by thickening of the left ventricle, otherwise known as the main squeezing chamber of the heart. HCM is best known for causing sudden death in athletes but can occur in persons of any age, often without symptoms.

26 Feb 2021

Blood News and Research

Efficacy of polymeric nano-micelles depends on expression level of c-Myc

MicroRNAs predict heart and kidney health in children without disease

Newly identified genes increase risk of obesity and also protect against this disease

Diverse patient population helps identify gene variant associated with childhood asthma

Atherosclerosis can speed up the development of clonal hematopoiesis

Study: Heart problems cause disturbed gene activity in the brain's memory center

Neanderthal-derived protein may protect against COVID-19 susceptibility and severity

Biomarkers in the blood can predict severe outcomes in COVID-19 patients

NLRP3 inflammasome inhibitors may help treat early COVID-19, says study

FDA permits marketing of new device to protect athletes from harmful effects of head impacts

Structure of SARS-CoV-2 envelope protein-epithelial cell junction protein complex explains virulence

Inhalable nanobody shows potent anti-SARS-CoV-2 activity in vivo

Single dose of Pfizer BioNTech vaccine can reduce asymptomatic SARS-CoV-2 infections

Is one dose of Pfizer-BioNTech mRNA vaccine for COVID-19 convalescents sufficient?

Biden’s straight-talking CDC director has long used data to save lives

New tool predicts trends and outcomes in individual patients

New approach can help treat hypertrophic cardiomyopathy with precision medicine

Programmed magnetic nanobeads rapidly diagnose COVID-19

New device accelerates transdermal penetration of drug molecules and extraction of interstitial fluid

Study examines the future psyche of post-COVID-19 traveler

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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