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Mail-order drug provider identifies $163B in potential prescription drug savings

A study by Express Scripts, a mail-order prescription drug provider, said Tuesday that an "estimated $163 billion in health care spending could be saved each year if patients took their medicines as prescribed, chose generic drugs and other low-cost alternatives, and had their prescriptions delivered by mail," the St. Louis Post-Dispatch reports. Express Scripts released its report at a two-day conference for clients in St. Louis.

22 Apr 2010

FDA approves Novartis Pharmaceuticals' Zortress for preventing rejection of kidney transplants

The US Food and Drug Administration (FDA) has approved Zortress® (everolimus) oral tablets for the prevention of rejection of kidney transplants in adult patients at low-to-moderate immunologic risk. Zortress is to be given in combination with reduced doses of the calcineurin inhibitor (CNI) cyclosporine, as well as basiliximab and corticosteroids.

22 Apr 2010

As more reform specifics emerge, so do questions, answers and impacts

As details of health reform policies shake out, questions, answers and consequences are emerging.

22 Apr 2010

Agios Pharmaceuticals presents data on cancer-associated IDH1 mutations at 101st AACR meeting

Agios Pharmaceuticals, a biopharmaceutical company focused on discovering and developing novel drugs in the field of cancer metabolism, today announced multiple presentations at the American Association for Cancer Research (AACR) 101st Annual Meeting that highlight cancer metabolism as an approach to identify new ways to treat cancer, opening the potential for a new class of cancer drugs targeting metabolic enzymes.

22 Apr 2010

Children born very early have abnormal lung function: U.K. researchers

More than half of children who were born very early—at 25 weeks or less (normal gestation is around 40 weeks)— have abnormal lung function and are twice as likely as their full-term peers to have a diagnosis of asthma, according to U.K. researchers, who followed a national cohort of extremely preterm infants to age 11.

22 Apr 2010

SpectraCell Laboratories introduces apolipoprotein E genotyping

Effective immediately, SpectraCell Laboratories now offers apolipoprotein E genotyping. This test determines a person's genetic risk for heart disease associated with the commonly studied gene called apoE, which is involved in the metabolism of cholesterol and triglycerides (fats in the blood).

22 Apr 2010

Seattle Genetics, Agensys present ASG-5ME ADC preclinical data at 101st AACR

Seattle Genetics, Inc. and Agensys, Inc., an affiliate of Tokyo-based Astellas Pharma Inc., today reported preclinical data with ASG-5ME, an antibody-drug conjugate (ADC) that is being co-developed by both companies for the treatment of solid tumors. In models of human prostate and pancreatic cancer, ASG-5ME was found to have potent and long lasting antitumor activity. The findings were presented at the 101st Annual Meeting of the American Association for Cancer Research (AACR) being held in Washington, D.C.

22 Apr 2010

NO-naproxen blocks molecular changes leading to colorectal cancer development

Past randomized clinical trials have shown that non-steroidal anti-inflammatory drugs (NSAIDs), including naproxen, can reduce the risk of colon cancer and precancerous polyps in humans. Now, researchers at Fox Chase Cancer Center have found that an investigational form of naproxen, called nitric oxide-donating naproxen (NO-naproxen), can block one of the earliest molecular changes that lead to colorectal cancer development while also reducing gastrointestinal toxicity, a relatively common side effect associated with NSAIDs.

22 Apr 2010

Proposed Medicare payment changes for hospitals would lower reimbursements slightly

The Wall Street Journal: "Hospital stocks moved higher Tuesday after the agency that runs Medicare proposed new inpatient services rates for the next fiscal year that were somewhat better than many had expected. Monday evening the Centers for Medicare & Medicaid Services said it would like to cut Medicare operating payments to acute care hospitals for inpatient services occurring in the next fiscal year by $142 million, or 0.1%. These figures don't include the impact of the new health-care reform law, which analysts said would cut the rate by another 0.25%".

22 Apr 2010

Study links mutations in RAD51C gene to breast and ovarian cancer

The discovery 15 years ago that the genes BRCA1 and BRCA2 confer high risks for breast and ovarian cancer was a breakthrough for cancer prediction and therapy, especially for familial cases. Now the research group of Prof. Alfons Meindl (Klinikum rechts der Isar of the Technische Universitaet Muenchen), in collaboration with other groups from Germany, the U.K., and the U.S., can identify another gene that increases susceptibility to breast and ovarian cancer.

22 Apr 2010

AFP reflects on WHO's response to H1N1

Agence France-Presse examines the WHO's response to H1N1 (swine flu) one year since the virus was first reported in Mexico and the U.S. "A year on, questions linger as to whether a decision by the World Health Organization to declare swine flu a pandemic, thereby unleashing the slew of health measures, was over-dramatic or even tainted by commercial interests," the news service writes.

22 Apr 2010

No more needles for vaccines – a two minute Nanopatch may suffice, say researchers

Vaccines have been associated with painful injections for a very long time. In a new and important discovery researchers have developed special ‘nano patches’ that can deliver vaccines without needles in just two minutes using 100 times less dose than used conventionally.

22 Apr 2010

New Department of Neurosurgery for UNC School of Medicine

The University of North Carolina at Chapel Hill School of Medicine is establishing a new Department of Neurosurgery, effective July 1, 2010.

22 Apr 2010

Infinity Pharmaceuticals initiates Phase 1b/2 trial of IPI-926 Hedgehog pathway inhibitor for pancreatic cancer

Infinity Pharmaceuticals, Inc., an innovative drug discovery and development company, today announced that it has initiated a randomized Phase 1b/2 clinical trial evaluating IPI-926, its novel, oral Hedgehog pathway inhibitor, in combination with gemcitabine in patients with pancreatic cancer.

22 Apr 2010

Study: Scientists advance toward development of urine test for detecting colon cancer

Scientists are reporting an advance toward development of a urine test for detecting colon cancer, the third most common cancer in the United States. Such a test could eventually compliment or even reduce the need for colonoscopy, the mainstay screening test used today. The study, which analyzes chemical differences in the urine of humans with and without colon cancer, is in ACS' Journal of Proteome Research, a monthly publication.

22 Apr 2010

Senate Democrats seek legislation to regulate insurer rate hikes

The New York Times: "Fearing that health insurance premiums may shoot up in the next few years, Senate Democrats laid a foundation on Tuesday for federal regulation of rates, four weeks after President Obama signed a law intended to rein in soaring health costs." Sen. Dianne Feinstein, D-Calif., introduced legislation that would allow the federal health secretary to block "any rate increase found to be unreasonable," an authority that would be shared with some state insurance officials.

22 Apr 2010

DDW2010 Investor Event to provide update on TARGET 1 and TARGET 2 Phase 3 trials

Salix Pharmaceuticals, Ltd. today announced that the Company will host a DDW2010 Investor Event on Monday, May 3 2010 from 9:00 p.m. to 10:00 p.m. Central Time (10:00 p.m. to 11:00 p.m. ET).

22 Apr 2010

Obama puts health care on 'back burner'

The Washington Post: President Barack Obama seems to have put health care on the back burner as he focuses on financial reform and nuclear proliferation.

22 Apr 2010

Affymetrix reports first-quarter total revenue of $80.2M

Affymetrix, Inc., today reported its operating results for the first quarter of 2010. Total revenue for the quarter was $80.2 million, as compared to total revenue of $78.6 million in the first quarter of 2009.

22 Apr 2010

People with vitiligo may have less risk of developing malignant melanoma: Research

People with the skin pigmentation disorder vitiligo may have less risk of developing life-threatening malignant melanoma, according to new research. The study also further confirms the suspicion that vitiligo is an autoimmune disease, which occur when the body's immune system reacts against its own tissues or organs.

22 Apr 2010

Research News and Research

Mail-order drug provider identifies $163B in potential prescription drug savings

FDA approves Novartis Pharmaceuticals' Zortress for preventing rejection of kidney transplants

As more reform specifics emerge, so do questions, answers and impacts

Agios Pharmaceuticals presents data on cancer-associated IDH1 mutations at 101st AACR meeting

Children born very early have abnormal lung function: U.K. researchers

SpectraCell Laboratories introduces apolipoprotein E genotyping

Seattle Genetics, Agensys present ASG-5ME ADC preclinical data at 101st AACR

NO-naproxen blocks molecular changes leading to colorectal cancer development

Proposed Medicare payment changes for hospitals would lower reimbursements slightly

Study links mutations in RAD51C gene to breast and ovarian cancer

AFP reflects on WHO's response to H1N1

No more needles for vaccines – a two minute Nanopatch may suffice, say researchers

New Department of Neurosurgery for UNC School of Medicine

Infinity Pharmaceuticals initiates Phase 1b/2 trial of IPI-926 Hedgehog pathway inhibitor for pancreatic cancer

Study: Scientists advance toward development of urine test for detecting colon cancer

Senate Democrats seek legislation to regulate insurer rate hikes

DDW2010 Investor Event to provide update on TARGET 1 and TARGET 2 Phase 3 trials

Obama puts health care on 'back burner'

Affymetrix reports first-quarter total revenue of $80.2M

People with vitiligo may have less risk of developing malignant melanoma: Research

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