Genes News and Research

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Prosigna Breast Cancer Prognostic Gene Signature Assay study published in JCO

NanoString Technologies, Inc., a provider of life science tools for translational research and molecular diagnostic products, today announced that the TransATAC clinical validation study for its Prosigna Breast Cancer Prognostic Gene Signature Assay, which is based on the PAM50 gene signature, was published in the Journal of Clinical Oncology.

From NanoString Technologies 2 Jul 2013

Scientists find new links in gene networks that control movement

The idea that worms can be seen as waveforms allowed scientists at Rice University to find new links in gene networks that control movement.

2 Jul 2013

Study offers new insights into how genome gets regulated by signalling molecules within human cells

There's not much difference between what makes a man and what makes his beer - at least at the molecular level - according to a new study led by Professor John Schwabe at the University of Leicester.

2 Jul 2013

Osteoarthritis associated genes: an interview with Professor Jonathan Tobias, University of Bristol

Joints are lined by articular cartilage, loss of which is one of the hallmarks of osteoarthritis. Articular cartilage is made up of a number of proteins, such as type II collagen. In rare forms of osteoarthritis, one of these structural proteins is defective as a result of a genetic mutation.

2 Jul 2013

Increased expression of Scara1 protein might impede progression of Alzheimer's disease: Study

Identification of a protein that appears to play an important role in the immune system's removal of amyloid beta (A-beta) protein from the brain could lead to a new treatment strategy for Alzheimer's disease. The report from researchers at Massachusetts General Hospital (MGH) has been published online in Nature Communications.

2 Jul 2013

UCSF researchers find that vitamin C may help stem cells, in vitro fertilization

Vitamin C affects whether genes are switched on or off inside mouse stem cells, and may thereby play a previously unknown and fundamental role in helping to guide normal development in mice, humans and other animals, a scientific team led by UC San Francisco researchers has discovered.

2 Jul 2013

UNC scientists use GEMMs to develop biomarkers for molecular subtypes of human breast cancer

It's a GEMM of a system. Genetically engineered mouse models that is. Using them allows scientists to study cancer in a way that more naturally mimics how human tumors exist within the complex environment of the body.

2 Jul 2013

Study reveals strain of V. cholerae in Haiti cholera outbreak originated from single source

The strain of cholera that has sickened thousands in Haiti came from a single source and was not repeatedly introduced to the island over the past three years as some have thought, according to a new study published in mBio-, the online open-access journal of the American Society for Microbiology.

2 Jul 2013

RORA: A novel candidate gene for autism regulates large number of other genes

A new study by Valerie Hu, Ph.D., professor of biochemistry and molecular medicine at the George Washington University (GW) School of Medicine and Health Sciences (SMHS), reports that RORA, a novel candidate gene for autism discovered by her group in a 2010 study, regulates a large number of other genes associated with autism.

2 Jul 2013

Arizona State University physicist explains new theory of cancer

With death rates from cancer have remained largely unchanged over the past 60 years, a physicist is trying to shed more light on the disease with a very different theory of its origin that traces cancer back to the dawn of multicellularity more than a billion years ago.

1 Jul 2013

Tiny RNA molecules work as powerful regulators of immune response in mammals

A team led by scientists at The Scripps Research Institute (TSRI) has identified a family of tiny RNA molecules that work as powerful regulators of the immune response in mammals. Mice who lack these RNA molecules lose their normal infection-fighting ability, whereas mice that overproduce them develop a fatal autoimmune syndrome.

1 Jul 2013

Study shows autophagy blockers play a role in treatment of non-small-cell lung cancer

New research from Rutgers Cancer Institute of New Jersey, Princeton University and other collaborators suggests that inactivation of an essential gene responsible for the cell survival process known as autophagy can suppress the growth of non-small-cell lung cancer tumors and render them more benign.

1 Jul 2013

Synthetic biology technology could lead to new antibiotics, modified protein-generators

Synthetic biology researchers at Northwestern University, working with partners at Harvard Medical School, have for the first time synthesized ribosomes -- cell structures responsible for generating all proteins and enzymes in our bodies -- from scratch in a test tube.

30 Jun 2013

Biomarker indicates which women are at risk for breast cancer recurrence after tamoxifen

A biomarker reflecting expression levels of two genes in tumor tissue may be able to predict which women treated for estrogen-receptor (ER)-positive breast cancer should receive a second estrogen-blocking medication after completing tamoxifen treatment.

30 Jun 2013

Low doses of arsenic and estrogen can cause cancer in prostate cells, study finds

Science knows that arsenic and estrogen can cause cancer. At certain very low levels, the chemicals offer little to no threats to human health.

29 Jun 2013

Case Comprehensive Cancer Center secures "outstanding" rating from NCI

The Case Comprehensive Cancer Center (CCCC) again demonstrated the compelling power of partnership in securing an overall rating of "outstanding" and a five-year renewal of its grant from the National Cancer Institute (NCI).

28 Jun 2013

New approaches to regenerate insulin-producing cells for type I diabetes

They have also shown that any pancreatic β cells can be regenerated several times and that chemically-induced diabetes in mice can thus be "treated" repeatedly. The challenge for the researchers is now to show that these procedures can be applied to humans.

28 Jun 2013

Chromosomal deletion associated with changes in brain's white matter and delays language acquisition

A chromosomal deletion is associated with changes in the brain's white matter and delayed language acquisition in youngsters from Southeast Asia or with ancestral connections to the region, said an international consortium led by researchers at Baylor College of Medicine.

28 Jun 2013

Research shows food contaminants are responsible for metabolic changes in obese mice

In order to get a better understanding of these effects, researchers from the Inserm cardiovascular, metabolism, diabetology and nutrition unit introduced a "cocktail" of contaminants mixed with low doses of dioxin, PCB, bisphenol A and phtalates into the feeding of mice that had already been rendered obese by a high-fat diet.

28 Jun 2013

Decorin protein in blood inhibits tumor progression, say researchers

Researchers from Thomas Jefferson University's Kimmel Cancer Center have discovered that decorin, a naturally occurring protein that circulates in the blood, acts as a potent inhibitor of tumor growth modulating the tumor microenvironment.

28 Jun 2013

Genes News and Research

Prosigna Breast Cancer Prognostic Gene Signature Assay study published in JCO

Scientists find new links in gene networks that control movement

Study offers new insights into how genome gets regulated by signalling molecules within human cells

Osteoarthritis associated genes: an interview with Professor Jonathan Tobias, University of Bristol

Increased expression of Scara1 protein might impede progression of Alzheimer's disease: Study

UCSF researchers find that vitamin C may help stem cells, in vitro fertilization

UNC scientists use GEMMs to develop biomarkers for molecular subtypes of human breast cancer

Study reveals strain of V. cholerae in Haiti cholera outbreak originated from single source

RORA: A novel candidate gene for autism regulates large number of other genes

Arizona State University physicist explains new theory of cancer

Tiny RNA molecules work as powerful regulators of immune response in mammals

Study shows autophagy blockers play a role in treatment of non-small-cell lung cancer

Synthetic biology technology could lead to new antibiotics, modified protein-generators

Biomarker indicates which women are at risk for breast cancer recurrence after tamoxifen

Low doses of arsenic and estrogen can cause cancer in prostate cells, study finds

Case Comprehensive Cancer Center secures "outstanding" rating from NCI

New approaches to regenerate insulin-producing cells for type I diabetes

Chromosomal deletion associated with changes in brain's white matter and delays language acquisition

Research shows food contaminants are responsible for metabolic changes in obese mice

Decorin protein in blood inhibits tumor progression, say researchers

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