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Immune mechanism in COVID-19 patients triggers cytokine storm

Researchers at the University of São Paulo (USP) in Brazil have demonstrated for the first time that in COVID-19 patients an immune mechanism known as the inflammasome participates in activation of the inflammatory process that can damage several organs and even lead to death.

2 Dec 2020

Repurposed mouse model sheds light on spectrum of COVID-19 disease symptoms

A repurposed mouse model can develop symptoms of both severe COVID-19 (lung damage, blood clots, abnormal blood vessels, and death) and also of milder disease, including loss of the sense of smell, according to a recent University of Iowa study published in Nature.

1 Dec 2020

PTC299 inhibits SARS-CoV-2 replication and suppresses production of inflammatory cytokines

In an article published in the journal Virus Research, a team of researchers from various US institutions discussed their study that evaluated the antiviral activity of PTC299 against a group of RNA viruses in vitro.

1 Dec 2020

OHDSI awarded $10 million FDA contract to support Biologics Effectiveness and Safety program

Researchers within the Observational Health Data Services and Informatics (OHDSI) community were recently awarded a $10 million contract from the U.S. Food and Drug Administration (FDA) to provide support to the Biologics Effectiveness and Safety (BEST) program, which was launched by the FDA Center for Biologics Evaluation and Research (CBER) in 2017.

1 Dec 2020

Researchers describe cellular mediator that makes muscle adaptation to exercise possible

The onset of any physical exercise program causes muscle pain that can hinder movements as simple as getting up from a sofa. With time and a little persistence, the muscles become accustomed to the effort, developing more strength and endurance.

1 Dec 2020

Microfiber- and nanofiber-based wearable monitors could keep track of patient’s vital signs

A shirt that monitors your blood pressure or a pair of socks that can keep track of your cholesterol levels might be just a few years away from becoming reality.

1 Dec 2020

More than 40 Dana-Farber studies to be presented at the virtual 62nd ASH Annual Meeting

Dana-Farber Cancer Institute researchers will present more than 40 research studies at the virtual 62nd American Society of Hematology Annual Meeting on December 5-8, including two studies that were selected for inclusion in the official press program.

1 Dec 2020

HIV 'wonder drug' may not be as effective as hoped in sub-Saharan Africa, study suggests

Dolutegravir, the current first-line treatment for HIV, may not be as effective as hoped in sub-Saharan Africa, suggests new research published on World AIDS Day. The study finds that this so-called 'wonder drug' may be less effective in patients resistant to older drugs.

1 Dec 2020

2018 anthrax outbreak in Uganda tied to infected cow meat, study finds

On April 18, 2018, 7 suspected human anthrax cases were reported from the Kween District Health Office in Kween District, Uganda. Ugandan researchers from the Uganda Public Health Fellowship Program, Kampala, Uganda, have now published their findings on the outbreak's source in the latest issue of the CDC's (Centre for Disease Prevention and Control) Emerging Infectious Diseases.

1 Dec 2020

How COVID-19 highlights the uncertainty of medical testing

Dr. Jacqueline Chu considered the man with a negative coronavirus test on the other end of the phone, and knew, her heart dropping, that the test result was not enough to clear him for work.

1 Dec 2020

Researchers uncover the role of protein in identifying common cold virus

The role of a protein in detecting the common cold virus and kickstarting an immune response to fight infection has been uncovered by a team of scientists from Nanyang Technological University, Singapore (NTU Singapore), the Agency for Science, Technology and Research (A*STAR) and the National University of Singapore.

1 Dec 2020

Direct oral anticoagulant does not appear to offer protection against severe COVID-19

DOAC (direct oral anticoagulant) pills are used in the treatment of atrial fibrillation by preventing blood clots. Even though blood clots are thought to contribute to complications from the new coronavirus infection, users of this class of drug do not seem to be protected against severe COVID-19, reports a large Swedish registry study from Karolinska Institutet published in The Journal of Internal Medicine.

1 Dec 2020

Chinese woman still sheds SARS-CoV-2 over four months post-infection

A new study by Chinese scientists explore an unusual case of extended viral shedding in a 68-year-old woman up to four months post-infection.

1 Dec 2020

Experimental stem cell gene therapy may give a new lease of life for patient with sickle cell disease

"But it's a marathon whereas you keep going, the trail gets rockier and then you lose your shoes," the 27-year-old said. "It gets harder as you get older. Things start to fail and all you can think about is how much worse it's going to get down the road."

1 Dec 2020

Multiple pregnancies may affect the body's physical aging process

Having children doesn't just make you feel like you've aged overnight -- a new study led by Penn State researchers found that the number of times a person gives birth may also affect the body's physical aging process.

1 Dec 2020

Gut microbiota directly shapes the makeup of human immune system, shows study

MSK researchers have uncovered an important finding about the relationship between the microbiota and the immune system, showing for the first time that the concentration of different types of immune cells in the blood changes in relation to the presence of different bacterial strains in the gut.

1 Dec 2020

Researchers successfully edit SIV virus from genomes of non-human primates

Taking a major step forward in HIV research, scientists at the Lewis Katz School of Medicine at Temple University have successfully edited SIV - a virus closely related to HIV, the cause of AIDS - from the genomes of non-human primates.

1 Dec 2020

Researchers report AI solution that could revolutionize medical research

Inside every cell, thousands of different proteins from the machinery that keeps all living things - from humans and plants to microscopic bacteria - alive and well. Almost all diseases, including cancer, dementia, and even infectious diseases such as COVID-19, are related to the way these proteins function.

1 Dec 2020

Clonal hematopoiesis linked to severe COVID-19

Now, an international team of researchers from the USA, South Korea and Canada has found that clonal hematopoiesis is tied to the risk of severe COVID-19.

30 Nov 2020

Researchers reveal how SARS-CoV-2 reaches the brain

Using post-mortem tissue samples, a team of researchers from Charité - Universitätsmedizin Berlin have studied the mechanisms by which the novel coronavirus can reach the brains of patients with COVID-19, and how the immune system responds to the virus once it does.

30 Nov 2020

Blood News and Research

Immune mechanism in COVID-19 patients triggers cytokine storm

Repurposed mouse model sheds light on spectrum of COVID-19 disease symptoms

PTC299 inhibits SARS-CoV-2 replication and suppresses production of inflammatory cytokines

OHDSI awarded $10 million FDA contract to support Biologics Effectiveness and Safety program

Researchers describe cellular mediator that makes muscle adaptation to exercise possible

Microfiber- and nanofiber-based wearable monitors could keep track of patient’s vital signs

More than 40 Dana-Farber studies to be presented at the virtual 62nd ASH Annual Meeting

HIV 'wonder drug' may not be as effective as hoped in sub-Saharan Africa, study suggests

2018 anthrax outbreak in Uganda tied to infected cow meat, study finds

How COVID-19 highlights the uncertainty of medical testing

Researchers uncover the role of protein in identifying common cold virus

Direct oral anticoagulant does not appear to offer protection against severe COVID-19

Chinese woman still sheds SARS-CoV-2 over four months post-infection

Experimental stem cell gene therapy may give a new lease of life for patient with sickle cell disease

Multiple pregnancies may affect the body's physical aging process

Gut microbiota directly shapes the makeup of human immune system, shows study

Researchers successfully edit SIV virus from genomes of non-human primates

Researchers report AI solution that could revolutionize medical research

Clonal hematopoiesis linked to severe COVID-19

Researchers reveal how SARS-CoV-2 reaches the brain

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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