Protein C News and Research

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Mutant mice administered with cocaine failed to exhibit hyperactivity, shows study

Cocaine is a highly addictive psychostimulant that induces complex molecular, cellular and behavioral responses. Despite various approaches and years of pre-clinical studies, effective, mechanism-based therapies to assist with cocaine misuse and dependence are still sorely lacking.

16 Jan 2019

Study: Ham bones contain peptides that could have cardioprotective effects

Drinking bone broth is a recent diet fad that proponents claim fights inflammation, eases joint pain and promotes gut health.

16 Jan 2019

Research finds large genome in tiny forest defoliator

The European gypsy moth is perhaps the country's most famous invasive insect - a nonnative species accidentally introduced to North America in the 1860s when a few escaped from a breeding experiment in suburban Boston.

16 Jan 2019

Researchers demonstrate how manganese produces parkinsonian syndrome

Using X-ray fluorescence at synchrotrons DESY and ESRF, researchers in the Centre d'Etudes Nucléaires de Bordeaux Gradignan have demonstrated the consequences of a mutation responsible for a hereditary parkinsonian syndrome: accumulated manganese in the cells appears to disturb protein transport.

16 Jan 2019

Breast cancer cells in mice coaxed to turn into harmless fat cells

As cancer cells respond to cues in their microenvironment, they can enter a highly plastic state in which they are susceptible to transdifferentiation into a different type of cell.

16 Jan 2019

Salk team uses new model to study health effects of AMP-activated protein kinase

The metabolic protein AMPK has been described as a kind of magic bullet for health. Studies in animal models have shown that compounds that activate the protein have health-promoting effects to reverse diabetes, improve cardiovascular health, treat mitochondrial disease--even extend life span.

16 Jan 2019

TGF-beta signaling pathway in uterine cells protects against cancer

Two new mouse models of uterine cancer shed light on how this disease - the most common gynecological cancer in the U.S. - happens.

16 Jan 2019

Researchers use gene-editing tool CRISPR/Cas9 to limit impact of parasitic diseases

For the first time, researchers at the George Washington University, together with colleagues at institutes in Thailand, Australia, the U.K. and the Netherlands, and more, have successfully used the gene-editing tool CRISPR/Cas9 to limit the impact of parasitic worms responsible for schistosomiasis and for liver fluke infection, which can cause a diverse spectrum of human disease including bile duct cancer.

16 Jan 2019

New immune response regulators discovered

The discovery was published in the new iScience journal for interdisciplinary research by Cell Press. The newly discovered regulatory proteins differ significantly from the regulators in mouse immune cells which have been reported earlier. Some of the proteins, such as SATB1 regulating the transcription of several genes, function in the opposite way in human compared to mouse.

16 Jan 2019

Study suggests key role for glial cells in Parkinson's disease

A team of scientists led by Prof. Antonella Consiglio from the IDIBELL and the University of Barcelona, and Prof. Angel Raya from the Center of Regenerative Medicine of Barcelona have discovered that defective versions of human brain cells called astrocytes are linked to the buildup of a toxic protein that is one the hallmarks of Parkinson's disease.

16 Jan 2019

Scientists reveal key mechanism in worms that controls cell's response to stress

Scientists have revealed a key mechanism in worms that is involved in controlling the cell's response to stress, a study in eLife reports.

16 Jan 2019

Scientists take another step in understanding bacteria that cause Salmonella epidemic

Scientists at the University of Liverpool have taken another step forward in understanding the bacteria that are causing a devastating Salmonella epidemic currently killing around 400,000 people each year in sub-Saharan Africa.

16 Jan 2019

New evidence shows how fever alters immune cells

Fever is known to help power up our immune cells, and scientists in Shanghai have new evidence explaining how.

16 Jan 2019

Researchers find how GREB1 gene promotes resistance to prostate cancer treatments

Researchers have discovered how a gene involved in regulating hormone receptors may contribute to drug resistance in some prostate cancer patients.

16 Jan 2019

Study points to potential new biomarker and drug target for amyotrophic lateral sclerosis

Research led by stem cell scientists at Harvard University points to a potential new biomarker and drug target for amyotrophic lateral sclerosis, a neurological disease that is extremely difficult to diagnose and treat.

16 Jan 2019

Researchers manipulate T cells to improve transplant success

Researchers have manipulated T cells in a way that prevents the rejection of transplanted organs, without affecting the immune system’s ability to fight microbial infection.

15 Jan 2019

Synthetic compound reverses mutant p53 aggregate accumulation, study shows

Cancer is a multidisciplinary disease, with different mutations leading to different prognoses and treatment necessities. Among the most important mutation targets in cancers, affecting more than 50% of all cancer cases, is TP53.

14 Jan 2019

Gut microbiome may help prevent development of cow's milk allergy

New research suggests that the gut microbiome may help prevent the development of cow's milk allergy. Scientists at the University of Chicago found that gut microbes from healthy human infant donors transplanted into mice protected animals exposed to milk from experiencing allergic reactions, while gut microbes transplanted from infants allergic to milk did not.

14 Jan 2019

Identifying genetic factors that lead to squamous cell carcinoma

Skin cancer is on the rise in the United States. Squamous cell carcinoma, the second most common form of cancer in the U.S., has the highest mortality rate of all non-melanoma skin cancers. In roughly two to five percent of patients, the disease will metastasize and spread throughout the body, making it difficult to treat.

14 Jan 2019

Scientists find link between colitis and colon cancer

Lingering inflammation in the colon is a known risk factor for colorectal cancer and now scientists report one way it resets the stage to enable this common and often deadly cancer.

14 Jan 2019