Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Researchers discover new active substance effective against gram negative bacteria

More and more bacterial pathogens of infectious diseases become resistant to customary antibiotics. Typical hospital germs such as Escherichia coli and Klebsiella pneumoniae have become resistant to the most - and in some cases even all - currently available antibiotics. Their additional external membrane makes these bacteria difficult to attack.

21 Nov 2019

Researchers uncover critical role of PKM2 protein in multiple inflammatory diseases

A research team in Trinity College Dublin has uncovered a critical role for a protein called 'PKM2' in the regulation of immune cell types at the heart of multiple inflammatory diseases.

21 Nov 2019

Extra DNA scooped up alongside cancer-causing genes helps drive tumor growth

One of the ways a cancer-causing gene works up enough power to turn a normal cell into a cancer cell is by copying itself over and over, like a Xerox machine.

21 Nov 2019

Tips for avoiding holiday headaches

Six tips for avoiding holiday headache triggers from Houston Methodist neurologist Bing Liao, M.D., M.Sc.

21 Nov 2019

Researchers design new antitumoral drug release strategy for breast cancer treatment

The local release of antitumoral drugs through bacterial proteins in the treatment of breast cancer can mark a before and after in precision medicine.

21 Nov 2019

Gene linked to Alzheimer’s plays indirect role in increasing delirium risk

Marked by acute temporary confusion, disorientation and/or agitation, postoperative delirium is the most common post-surgical complication in older adults, striking as many as half of adults older than 65 who undergo high-risk procedures such as cardiac surgery or hip replacements.

21 Nov 2019

Doughnut-shaped circles of ecDNA provide tumor cells with a malignant twist

Deoxyribonucleic acid or DNA encodes information, not only in its sequence but also in its shape.

21 Nov 2019

Experimental vaccine elicits antibodies that can neutralize multiple HIV strains

An experimental HIV vaccine developed by scientists at Scripps Research and the nonprofit vaccine research organization IAVI has reached an important milestone by eliciting antibodies that can neutralize a wide variety of HIV strains.

21 Nov 2019

Recently discovered protein may play key role in obesity and metabolic disease

With unexpected findings about a protein that's highly expressed in fat tissue, scientists at Scripps Research have opened the door to critical new understandings about obesity and metabolism.

21 Nov 2019

Exploring the links between chronic stress, inflammation and depression

Chronic stress can inflame our brain, destroy the connections between our neurons and result in depression, scientists say.

21 Nov 2019

Consumption of beans and other legumes benefits cardiovascular health

Consuming beans, lentils, peas, and other legumes reduces the risk for cardiovascular disease, coronary heart disease, and high blood pressure, according to a review published in Advances in Nutrition.

20 Nov 2019

Researchers identify a promising drug pair to attack deadly childhood brain cancers

Researchers have devised a new plan of attack against a group of deadly childhood brain cancers collectively called diffuse midline gliomas, including diffuse intrinsic pontine glioma, thalamic glioma and spinal cord glioma.

20 Nov 2019

Inflammatory processes drive progression of neurodegenerative brain diseases

Inflammation drives the progression of neurodegenerative brain diseases and plays a major role in the accumulation of tau proteins within neurons.

20 Nov 2019

Researchers uncover novel pathogenic mechanism in Huntington’s disease

Researchers from the Institute of Neurosciences of the University of Barcelona and the August Pi i Sunyer Biomedical Research Institute described a mechanism, the increase of proteinaceous synthesis, which takes part in the degeneration of the type of neurons that are affected in Huntington's disease, a genetic neurodegenerative disease.

20 Nov 2019

Newly developed ChiTaRS database can collect cases of druggable fusion targets

When sections from two separate genes merge due to various factors, such as translocation or splicing, the hybrid that is formed is called a gene fusion. In recent years, it has been discovered that these fusion events play a vital role in the development of cancers and other complex diseases.

20 Nov 2019

Fosun Pharma, MimiVax to jointly develop and commercialize SurVaxM therapy in U.S.

The inventors of a new and unique cancer immunotherapy developed at Roswell Park Comprehensive Cancer Center have announced a major step forward with that therapy, known as SurVaxM. MimiVax LLC principals Robert Fenstermaker, MD, and Michael Ciesielski, PhD, have announced that the company, spun off from Roswell Park in 2012, has entered into a China-exclusive licensing agreement for SurVaxM with Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd., a wholly-owned subsidiary of Shanghai Fosun Pharmaceutical Co. Ltd. based in Shanghai, China.

20 Nov 2019

ETVAX vaccine candidate shows promise against enterotoxigenic E. coli diarrhea

University of Gothenburg reports first successful results of the oral, inactivated vaccine candidate ETVAX against enterotoxigenic E. coli diarrhea in a placebo-controlled phase I/II study in infants and children from 6 months to 5 years of age in Bangladesh.

20 Nov 2019

Breakthrough therapy could improve health and survival in people with cystic fibrosis

Researchers at the Children's Hospital Colorado Breathing Institute, one of the largest cystic fibrosis clinical care centers in the U.S., are part of a Therapeutics Development Network that oversaw clinical trials leading to FDA approval of TRIKAFTA, a new, highly-effective CF treatment for people with CF 12 years of age and older.

20 Nov 2019