RNA Sequencing News and Research

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'Myeloid mimicry' identified as driver of immunotherapy resistance in renal medullary carcinoma

Researchers at The University of Texas MD Anderson Cancer Center have found that renal medullary carcinoma (RMC) cells use an adaptive mechanism called "myeloid mimicry" to hide from the immune system and promote disease hyper progression after immunotherapy, highlighting specific targets that overcome treatment resistance in preclinical models.

25 Nov 2025

Long-term calorie restriction can slow cellular markers of brain aging

As the brain ages, cells in the central nervous system experience metabolic dysfunction and increased oxidative damage.

25 Nov 2025

Scientists uncover how brain enzyme OTULIN controls tau expression

Scientists have uncovered a surprising mechanism by which a brain enzyme called OTULIN controls the expression of tau, the protein that forms toxic tangles in Alzheimer's disease.

25 Nov 2025

Single-cell RNA sequencing uncovers diverse CD4⁺ T-cell subtypes in pediatric lupus

Detailed mapping of CD4⁺ T cells from children with systemic lupus erythematosus (SLE) has revealed distinct immune cell subsets with likely roles in disease pathogenesis, according to a study led by Weill Cornell Medicine investigators.

24 Nov 2025

Kimchi consumption strengthens antigen recognition and immune regulation

Amid concerns about the simultaneous spread of multiple respiratory diseases, such as colds and influenza, with the change of seasons in current times, a recent clinical study has scientifically proven that kimchi, a traditional Korean fermented food, enhances the function of human immune cells and maintains the balance of the immune system.

24 Nov 2025

Study reveals how gestational diabetes disrupts the placenta at the molecular level

Gestational diabetes can cause a multitude of complications in the offspring, but to date, the reasons are incompletely understood.

18 Nov 2025

Single-cell study reveals how HPV shapes immune landscape in penile cancer

Although penile cancer represents less than 1% of male malignancies, it carries substantial physical and psychological burden, with a five-year survival rate near 50%.

13 Nov 2025

Common antibiotic can improve survival and neurological outcomes in CNS-TB

Researchers at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have demonstrated that doxycycline, a commonly available and inexpensive antibiotic, can improve survival rates and neurological outcomes in Central Nervous System Tuberculosis (CNS-TB) in a preclinical non-human study.

12 Nov 2025

AI chat box helps investigate complex biology in English language

Using sophisticated RNA sequencing technology, biomedical researchers can measure the activity of our genes across millions of single cells, creating detailed maps of tissues, organs, and diseases.

11 Nov 2025

Single-cell analysis reveals HPV-induced keratinocyte heterogeneity in cervical cancer

Cervical squamous cell carcinoma (CESC), the most prevalent subtype of cervical cancer, remains a major global health burden driven primarily by persistent high-risk HPV infection and genetic susceptibility.

7 Nov 2025

SPT Labtech and Alithea Genomics collaborate to automate ultra sensitive single-cell transcriptomic workflows

SPT Labtech, a global leader in the design and development of laboratory automation and liquid handling solutions, and Alithea Genomics, a pioneer in the field of large-scale RNA sequencing and transcriptomics, today announced a collaboration to provide an automated solution for single-cell transcriptomics.

5 Nov 2025

Stress hormones may silence crucial neuronal genes through specific RNA molecules

What if the brain's response to stress could be read not in fleeting neurotransmitter bursts, but in the quieting of genes deep inside chromatin? Researchers at the University of Alabama at Birmingham have now shown that stress hormones may silence crucial neuronal genes through an unexpected class of RNA molecules that operate not by encoding proteins, but by reshaping the genome's architecture.

4 Nov 2025

Mapping how the heart heals after a heart attack

Over the course of evolution, the human heart has largely lost its ability to regenerate. Our distant ancestors were not afflicted by heart attacks - a condition that emerged primarily with modern lifestyles marked by poor diet, obesity, and other cardiovascular risk factors.

3 Nov 2025

Kids First DRC releases 37th pediatric study on rare childhood cancers

The Gabriella Miller Kids First Data Resource Center (Kids First DRC) has released its 37th pediatric research study, available in the Kids First Data Resource Portal.

3 Nov 2025

Large-scale foundation model reconstructs how cells interact within tissues

Researchers at Helmholtz Munich and the Technical University of Munich (TUM) have developed Nicheformer, the first large-scale foundation model that integrates single-cell analysis with spatial transcriptomics.

3 Nov 2025

Urolithin A recharges aging immune cells and boosts mitochondrial fitness in midlife adults

Urolithin A, a natural postbiotic known to trigger mitophagy, rejuvenated key immune cell functions in healthy middle-aged adults after 28 days. The trial showed a shift toward a youthful, energy-efficient CD8⁺ T-cell profile and enhanced bacterial clearance without inflammatory side effects.

3 Nov 2025

RNA Sequencing News and Research

'Myeloid mimicry' identified as driver of immunotherapy resistance in renal medullary carcinoma

Long-term calorie restriction can slow cellular markers of brain aging

Scientists uncover how brain enzyme OTULIN controls tau expression

Single-cell RNA sequencing uncovers diverse CD4⁺ T-cell subtypes in pediatric lupus

Kimchi consumption strengthens antigen recognition and immune regulation

Study reveals how gestational diabetes disrupts the placenta at the molecular level

Single-cell study reveals how HPV shapes immune landscape in penile cancer

Common antibiotic can improve survival and neurological outcomes in CNS-TB

AI chat box helps investigate complex biology in English language

Single-cell analysis reveals HPV-induced keratinocyte heterogeneity in cervical cancer

SPT Labtech and Alithea Genomics collaborate to automate ultra sensitive single-cell transcriptomic workflows

Stress hormones may silence crucial neuronal genes through specific RNA molecules

Mapping how the heart heals after a heart attack

Kids First DRC releases 37th pediatric study on rare childhood cancers

Large-scale foundation model reconstructs how cells interact within tissues

Urolithin A recharges aging immune cells and boosts mitochondrial fitness in midlife adults

Proimmune Ltd introduces Prove® SL Self-Loading MHC Class I Monomers to improve T cell research flexibility

Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway

Fundamental challenges and cutting-edge strategies in developing new GBM CAR-T therapies

Research identifies biomarkers in blood to fine-tune breast cancer interventions

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