Genes News and Research

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Specific transporters could be exploited to deliver toxic substances into cancer cells

Whitehead Institute scientists report that certain molecules present in high concentrations on the surfaces of many cancer cells could be exploited to funnel lethal toxic molecules into the malignant cells. In such an approach, the overexpression of specific transporters could be exploited to deliver toxic substances into cancer cells.

3 Dec 2012

Researchers discover four new gene regions that contribute to low birth weight

An international team of genetics researchers has discovered four new gene regions that contribute to low birth weight. Three of those regions influence adult metabolism, and appear to affect longer-term outcomes such as adult height, risk of type 2 diabetes and adult blood pressure.

3 Dec 2012

Scientists identify 15 new genetic regions associated with coronary artery disease

Fifteen new genetic regions associated with coronary artery disease have been identified by a large, international consortium of scientists - including researchers at the Stanford University School of Medicine - taking a significant step forward in understanding the root causes of this deadly disease. The new research brings the total number of validated genetic links with heart disease discovered through genome-wide association studies to 46.

3 Dec 2012

Children with changes in bully genes have poor survival

In a genome sequencing study of 74 neuroblastoma tumors in children, scientists at the Johns Hopkins Kimmel Cancer Center and the Children's Hospital of Philadelphia (CHOP) found that patients with changes in two genes, ARID1A and ARID1B, survive only a quarter as long as patients without the changes. The discovery could eventually lead to early identification of patients with aggressive neuroblastomas who may need additional treatments.

3 Dec 2012

Scientists discover how humans and mammals develop intelligence

Scientists have discovered for the first time how humans - and other mammals - have evolved to have intelligence.

3 Dec 2012

TINCR molecule plays a master role in epidermal differentiation

The surface of your skin, called the epidermis, is a complex mixture of many different cell types - each with a very specific job. The production, or differentiation, of such a sophisticated tissue requires an immense amount of coordination at the cellular level, and glitches in the process can have disastrous consequences. Now, researchers at the Stanford University School of Medicine have identified a master regulator of this differentiation process.

2 Dec 2012

Scientists demonstrate how glowing fish can help screen drugs that control metabolic disorders

A tiny, translucent zebrafish that glows green when its liver makes glucose has helped an international team of researchers identify a compound that regulates whole-body metabolism and appears to protect obese mice from signs of metabolic disorders.

2 Dec 2012

Scientists sequence DNA of biopsied tissue from colon polyps

The causes underlying the development of certain types of common cancers have not yet been elucidated. In order to better determine the origin and the sequence of events responsible for the onset of colon cancer, the teams led by Thanos Halazonetis and Stylianos Antonarakis, professors at the University of Geneva (UNIGE), Switzerland, have sequenced the DNA of biopsied tissue from colon polyps.

2 Dec 2012

Researchers uncover molecular structure of master regulator central to melanoma

With the X-ray vision of DESY's light source DORIS, a research team from Hamburg and Iceland has uncovered the molecular structure of a master regulator central to the most deadly form of skin cancer, melanoma.

1 Dec 2012

Scientists can produce new proteins by following certain rules

By following certain rules, scientists can prepare architectural plans for building ideal protein molecules not found in the real world. Based on these computer renditions, previously non-existent proteins can be produced from scratch in the lab. The principles to make this happen appear this month in Nature magazine.

1 Dec 2012

New genetic study defines biology behind brain developmental disorder in children

This study describes how a combination of sequencing and mouse models were used to identify the gene responsible for a brain developmental disorder seen in four patients.

1 Dec 2012

New study on mice could open door to methods of regulating cell proliferation in humans

A newly-engineered strain of mice whose dividing cells express a fluorescent protein could open the door to new methods of regulating cell proliferation in humans.

1 Dec 2012

Caregiving associated with increased cardiovascular disease risk

People acting as caregivers for family members with cardiovascular disease may inadvertently increase their own risk for heart disease by neglecting their own health, according to a new study in the American Journal of Health Promotion.

1 Dec 2012

NAP and SAL injection during pregnancy improve memory, learning tasks in offsprings

Mice with a condition that serves as a laboratory model for Down syndrome perform better on memory and learning tasks as adults if they were treated before birth with neuroprotective peptides, according to researchers at the National Institutes of Health.

30 Nov 2012

HDAC6 enzyme could be possible target for therapies against Alzheimer's

Scientists from the DZNE sites in G-ttingen and Bonn, the UMG as well as from the US participated in this basic research project on Alzheimer's disease. The study is published in "EMBO Molecular Medicine".

30 Nov 2012

Fly model may help unravel genetic events that take place until development of a tumour

The wing of a fruit fly may hold the key to unraveling the genetic and molecular events that transform a normal cell into a cancerous one. The study, conducted on Drosophila melanogaster by scientists at the Institute for Research in Biomedicine (IRB Barcelona) and led by ICREA researcher Marco Mil-n, has reproduced each of the steps known to take place when a healthy cell turns cancerous.

30 Nov 2012

Scientists identify two genes involved in establishing neuronal circuits required for breathing

Scientists at NYU Langone Medical Center have identified two genes involved in establishing the neuronal circuits required for breathing. They report their findings in a study published in the December issue of Nature Neuroscience.

30 Nov 2012

Combination of chemotherapy and selumetinib shows promise against NSCLC

A new study by an international team of investigators led by Dana-Farber Cancer Institute scientists is the first to demonstrate that chemotherapy and a new, targeted therapy work better in combination than chemotherapy alone in treating patients with the most common genetic subtype of lung cancer.

30 Nov 2012

JQ1 cancer drug may be useful in purging latent HIV infection

Breakthrough drugs have made it possible for people to live with HIV longer than ever before, but more work must be done to actually cure the disease. One of the challenges researchers face involves fully eradicating the virus when it is latent in the body.

30 Nov 2012

Article highlights Asian-American children’s variable vulnerability to obesity

Asian-American children have been at low risk for being overweight or obese compared to other racial and ethnic groups in the U.S., but that may be changing. Yet as rates of overweight and obesity rise, the risk appears to vary depending on the Asian country of origin, according to an article in Childhood Obesity, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

30 Nov 2012

Genes News and Research

Specific transporters could be exploited to deliver toxic substances into cancer cells

Researchers discover four new gene regions that contribute to low birth weight

Scientists identify 15 new genetic regions associated with coronary artery disease

Children with changes in bully genes have poor survival

Scientists discover how humans and mammals develop intelligence

TINCR molecule plays a master role in epidermal differentiation

Scientists demonstrate how glowing fish can help screen drugs that control metabolic disorders

Scientists sequence DNA of biopsied tissue from colon polyps

Researchers uncover molecular structure of master regulator central to melanoma

Scientists can produce new proteins by following certain rules

New genetic study defines biology behind brain developmental disorder in children

New study on mice could open door to methods of regulating cell proliferation in humans

Caregiving associated with increased cardiovascular disease risk

NAP and SAL injection during pregnancy improve memory, learning tasks in offsprings

HDAC6 enzyme could be possible target for therapies against Alzheimer's

Fly model may help unravel genetic events that take place until development of a tumour

Scientists identify two genes involved in establishing neuronal circuits required for breathing

Combination of chemotherapy and selumetinib shows promise against NSCLC

JQ1 cancer drug may be useful in purging latent HIV infection

Article highlights Asian-American children’s variable vulnerability to obesity

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