Biochemistry News and Research

RSS

Dynamics of crucial immune system proteins revealed

Of the many marvels of the human immune system, the processing of antigens by the class I proteins of the major histocompatability complex (MHC-I) is among the most mind-boggling. Exactly how these proteins carry out their crucial functions has not been well understood.

3 Dec 2019

Researchers identify brain networks that play key role in suicide risk

An international team of researchers has identified key networks within the brain they say interact to increase the risk that an individual will think about - or attempt - suicide.

2 Dec 2019

Changes in certain brain networks seem to be linked to suicide risk

Scientists have identified patterns of brain activity that may be associated with increased risk of suicide.

2 Dec 2019

Over €12 million funding to advance autophagy research

Four years ago, Collaborative Research Centre (CRC) 1177 on selective autophagy was established under the leadership of Goethe University - now the German Research Foundation has given the green light for its further funding.

27 Nov 2019

Research could help design better flu vaccines

Each year millions of Americans become sick with the flu, hundreds of thousands are hospitalized and tens of thousands die. Getting the flu shot can reduce the chances of infection. But, at best, the vaccine is only effective 40% to 60% of the time, according to the CDC.

26 Nov 2019

Mcl-1 inhibition blocks cell survival in ER+ breast cancers

While estrogen receptor - + breast cancers express high levels of three anti-apoptotic Bcl-2 family members, pharmacological inhibition of Bcl-2 and/or Bcl-xL fails to induce cell death in ER + breast cancer cell lines, due to rapid and robust Mcl-1 upregulation.

26 Nov 2019

Hops compounds may combat metabolic syndrome by changing the gut microbiome

Compounds from hops may combat metabolic syndrome by changing the gut microbiome and altering the metabolism of acids produced in the liver, new research at Oregon State University suggests.

26 Nov 2019

FDA-approved drug to prevent organ rejection may slow skin aging

The search for youthfulness typically turns to lotions, supplements, serums and diets, but there may soon be a new option joining the fray.

25 Nov 2019

Research yields potent antimicrobial that works against staph infection

Research led by scientists from McMaster University has yielded a potent antimicrobial that works against the toughest infectious disease strains. The find could be the beginning of developing new therapeutics to combat drug-resistant infections.

25 Nov 2019

Potent antimicrobial could combat antibiotic-resistant MRSA infections

Scientists have discovered a strong antimicrobial that is effective against some of the strongest infectious diseases.

25 Nov 2019

New study provides better understanding of blood clot formation in cancer patients

Researchers have identified a potential new signaling pathway that may help further the understanding of blood clot formation in cancer patients and ultimately help prevent this complication from occurring.

22 Nov 2019

Researchers uncover critical role of PKM2 protein in multiple inflammatory diseases

A research team in Trinity College Dublin has uncovered a critical role for a protein called 'PKM2' in the regulation of immune cell types at the heart of multiple inflammatory diseases.

21 Nov 2019

Immunity within the lung tissue provides most protection for preventing pneumonia

Previous research has shown that recovery from bacterial pneumonia hugely improves our defense against further infections by seeding the lungs with immune cells called lung resident memory T (TRM) cells, but how these cells actually protect the lungs against future bacterial infections has been unknown until now.

21 Nov 2019

New gene mutation involved in familial thyroid cancers identified

Researchers from Penn State College of Medicine identified a new gene mutation that may cause a type of familial thyroid cancer.

20 Nov 2019

Applying a Proteomics-based Approach to the Clinic

Matthias Mann explains why applying proteomics-based technologies such as timsTOF could accelerate the diagnosis and prediction of human disease.

From Bruker Daltonics 20 Nov 2019

Oral vaccination with cholera toxin helps counteract age-associated obesity

Here the research team tested a safe and well-established microbe-based immune adjuvant to restore immune homeostasis and counteract inflammation-associated obesity in animal models.

19 Nov 2019

New database helps identify therapeutic targets to fight infectious diseases

Infectious diseases are caused by pathogenic microorganisms capable of entering, colonizing and growing within a host organism, thus producing an infection. Bacterial infections have been on the rise worldwide in recent years, but many mechanisms underlying bacterial pathogenesis are still poorly understood.

19 Nov 2019

Researchers identify new mechanism to resist fungal infection in cells

Indiana University researchers have identified a mechanism involving the body's ability to resist fungal infection. The work could help advance research on cancer therapies that use the body's own immune system to fight disease.

18 Nov 2019

Scientists reverse learning and memory deficits with drugs in animal model of Down syndrome

In a surprising finding using the standard animal model of Down syndrome (DS), scientists were able to correct the learning and memory deficits associated with the condition -- the leading genetic cause of cognitive disability and the most frequently diagnosed chromosomal disorder in the U.S. -- with drugs that target the body's response to cellular stresses.

15 Nov 2019

Study unravels how insulin interacts with its receptor

Since the discovery of insulin nearly 100 years ago, scientists have explored how it interacts with its receptor with the goal of improving the ability of therapeutic insulins to mimic the way insulin works in the body.

14 Nov 2019