Genes News and Research

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Fat tissue different in men and women

The age-old question of why men store fat in their bellies and women store it in their hips may have finally been answered: Genetically speaking, the fat tissue is almost completely different.

15 May 2010

Oxygen levels induce X chromosome inactivation in female cells: Study

Oxygen levels in the lab can permanently alter human embryonic stem (ES) cells, specifically inducing X chromosome inactivation in female cells, according to Whitehead Institute researchers. Human ES cells have been routinely created and maintained at atmospheric levels of oxygen, which is about 20%. Cells in the body are usually exposed to only 1-9% oxygen.

14 May 2010

Measuring gene expression in healthy women may predict future breast cancer risk, say scientists

Researchers at Georgetown Lombard Comprehensive Cancer Center have been able to show, in mice, how just a little adjustment in the expression of two common genes can promote the kind of cellular changes that led to breast cancer. They say these tweaks likely mimic natural variation women have in expression of the two genes.

14 May 2010

Mild-mannered organelles can detect virus invasion signals: Researchers

Within cells, an ancient antiviral duo can deliver a one-two knockout to thwart invading viruses, report researchers who have just unmasked the cellular sidekick that throws the first punch. The findings mean scientists must rethink the design of antiviral immunity and how the body fends off viruses of all types, including influenza and HIV.

14 May 2010

CyGene Laboratories reports heightened interest in at-home genetic testing

CyGene Laboratories Inc. today announced that it has experienced unprecedented levels of interest and requests for information following recent media coverage of Walgreens' decision to offer genetics testing kits supplied by Pathway Genomics in certain of their retail stores.

13 May 2010

Research article focuses on how IECs respond to probiotic strain B. lactis HN019

Probiotics are a group of live microorganisms administered in adequate amounts which confer a beneficial health effect on the host. This bacterial community plays a pivotal role in human nutrition and health by promoting the supply of nutrients, preventing pathogen colonization and shaping and maintaining normal mucosal immunity.

13 May 2010

Researchers to discuss various implications for personalized medicine during one-day symposium

On May 27, researchers with the National Human Genome Research Institute and the National Cancer Institute, along with Group Health Cooperative in Seattle and Henry Ford Health System, will debate and discuss that question during the one-day symposium "Multiplex Initiative: Implications for Personalized Medicine."

13 May 2010

Four caged xanthones can inhibit growth of CCA cell lines: Research article

Cholangiocarcinoma is a malignant tumor, characterized by a poor prognosis and unresponsive to conventional chemotherapeutic agents. Therefore, searching for novel and effective therapeutic agents for CCA is necessary. In previous studies, several caged xanthones from G. hanburyi have been reported to be potent antiproliferatives as well as having anticancer and anti-tumor activities and they induce apoptosis in various cancer cell lines.

13 May 2010

NARSAD honours UNC's Patrick Sullivan with 2010 Distinguished Investigator Award

Patrick Sullivan, MD has received a 2010 Distinguished Investigator Award from NARSAD for a comparison of genetics in schizophrenia and bipolar disorder.

13 May 2010

Research sheds light on prenatal heart formation, chromosome 22q.11 deletion syndrome

Researchers studying the common genetic disorder chromosome 22q.11 deletion syndrome have identified key proteins that act together to regulate early embryonic development. One protein is essential to life; in animal studies, embryos without the protein do not survive past the first few days of gestation.

13 May 2010

Tracking genes in infant's intestine helps compare early development of breast-fed and formula-fed babies

Is breast milk so different from infant formula? The ability to track which genes are operating in an infant's intestine has allowed University of Illinois scientists to compare the early development of breast-fed and formula-fed babies. They say the difference is very real.

13 May 2010

Researchers develop new technology to manage prostate cancer treatment

Researchers at Queen's University have developed a new way of performing lab tests that could improve the way doctors manage prostate cancer treatment. It will allow them to identify with unprecedented accuracy losses of a gene called PTEN that is associated with an aggressive group of prostate cancers.

13 May 2010

Clinical Data expands PGxHealth's FAMILION tests to include two new tests to diagnose heart diseases

Clinical Data, Inc., announced today that its PGxHealth division is expanding its FAMILION family of genetic tests to include two new tests to diagnose heart diseases. With the launch of a test for Conduction Disease associated with Dilated Cardiomyopathy and a test for Short QT Syndrome, PGxHealth continues to lead the industry with the most comprehensive menu of genetic tests to diagnose or confirm familial heart diseases.

12 May 2010

Genetic variations do not improve ability to predict risk of AD: Study

Although genome-wide analysis identified two genetic variations associated with Alzheimer disease, these variations did not improve the ability to predict the risk of AD, according to a study in the May 12 issue of JAMA.

12 May 2010

Response Genetics, GSK sign non-exclusive license agreement for BRAF mutational analysis technology

Response Genetics, Inc., a company focused on the development and sale of molecular diagnostic tests for cancer, today announced it has signed a non-exclusive license agreement with GlaxoSmithKline ("GSK"). Under the terms of the agreement, GSK gains certain rights to Response Genetics' proprietary PCR analysis technology and diagnostic expertise to assess BRAF gene mutations in human tumor samples. Payments will be made to Response Genetics upon achivement of agreed-to milestones.

12 May 2010

Researchers develop new method for tracing carbon flux

Microbial communities are performing important functions all around us - from the earth in our flowerpots to the human gut. Now researchers have developed a method for studying the metabolic functions of microbial communities in detail.

12 May 2010

Johns Hopkins Bloomberg School of Public Health awarded Grand Challenges Explorations grant

The Johns Hopkins Bloomberg School of Public Health announced today that it has received a $100,000 Grand Challenges Explorations grant from the Bill & Melinda Gates Foundation. The grant will support an innovative global health research project conducted by Jason Rasgon, PhD, an assistant professor with the Johns Hopkins Malaria Research Institute, and his research to develop an evolution-proof pesticide for eliminating mosquitoes that transmit malaria to humans.

12 May 2010

Pathway Genomics personal genetic testing kits to be sold at Walgreens

Pathway Genomics, a U.S.-based genetic testing company, today announced that Pathway's personal genetic testing kits will be available at Walgreens. Starting in mid-May the Pathway Genomics Insight™ Saliva Collection Kit will be sold at many of Walgreens' nearly 7,500 stores nationwide (with the exception of New York, due to a New York state law). The Insight™ Saliva Collection Kit will retail in the $20 to $30 price range.

11 May 2010

Gene variations may increase risk of developing schizophrenia: Study

By analyzing the genomes of patients with schizophrenia, genetics researchers have discovered numerous copy number variations—deletions or duplications of DNA sequences—that increase the risk of developing schizophrenia. Significantly, many of these variations occur in genes that affect signaling among brain cells.

11 May 2010

New combination therapy may help treat anti-estrogen resistant ER+ breast cancer

A study by researchers from the Georgetown Lombardi Comprehensive Cancer Center at Georgetown University Medical Center (GUMC) identifies a potential new combination therapy to "rescue" treatment sensitivity to fulvestrant in estrogen receptor positive breast cancers.

11 May 2010

Genes News and Research

Fat tissue different in men and women

Oxygen levels induce X chromosome inactivation in female cells: Study

Measuring gene expression in healthy women may predict future breast cancer risk, say scientists

Mild-mannered organelles can detect virus invasion signals: Researchers

CyGene Laboratories reports heightened interest in at-home genetic testing

Research article focuses on how IECs respond to probiotic strain B. lactis HN019

Researchers to discuss various implications for personalized medicine during one-day symposium

Four caged xanthones can inhibit growth of CCA cell lines: Research article

NARSAD honours UNC's Patrick Sullivan with 2010 Distinguished Investigator Award

Research sheds light on prenatal heart formation, chromosome 22q.11 deletion syndrome

Tracking genes in infant's intestine helps compare early development of breast-fed and formula-fed babies

Researchers develop new technology to manage prostate cancer treatment

Clinical Data expands PGxHealth's FAMILION tests to include two new tests to diagnose heart diseases

Genetic variations do not improve ability to predict risk of AD: Study

Response Genetics, GSK sign non-exclusive license agreement for BRAF mutational analysis technology

Researchers develop new method for tracing carbon flux

Johns Hopkins Bloomberg School of Public Health awarded Grand Challenges Explorations grant

Pathway Genomics personal genetic testing kits to be sold at Walgreens

Gene variations may increase risk of developing schizophrenia: Study

New combination therapy may help treat anti-estrogen resistant ER+ breast cancer

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