Clinical Trial News and Research

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Distinct immune profiles linked to adverse reactions from immunotherapy

Distinct immune "signatures" in patients who develop adverse events while taking immunotherapy for cancer may help oncologists identify patients at risk and treat them early to prevent serious side effects, suggests a study by researchers from the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

15 Oct 2024

Emory University researchers shift focus to neuroinflammation in Alzheimer's treatment

For decades, Alzheimer's research has focused on examining amyloid plaques in the brain and prescribing antibody therapeutics that remove the plaques to slow cognitive decline in patients.

15 Oct 2024

Multidisciplinary approach improves quality of life in functional movement disorders

The research team of the Neurology Department Movement Disorders Unit at the Virgen del Rocío University Hospital and the Movement Disorders group of the Institute of Biomedicine of Seville - IBiS, in collaboration with researchers from the Mental Health Clinical Management Unit and the Translational Psychiatry group coordinated by Benedicto Crespo Facorro (HUVR-IBiS/CIBERSAM), has published a randomized clinical trial demonstrating for the first time that a multidisciplinary approach integrating specific physiotherapy and cognitive-behavioral therapy is effective in improving the symptoms and physical aspects of the quality of life of patients with functional movement disorders.

12 Oct 2024

New study reveals unique metabolic function of lung-resident NK immune cells

Trinity College Dublin researchers, based at St James's Hospital have provided important insights into the behavior and metabolic function of a previously largely unknown, but crucial 'natural killer' (NK) immune cell resident in the lungs.

12 Oct 2024

Mount Sinai launches new center for complex chronic illnesses

Mount Sinai's Department of Rehabilitation and Human Performance has announced the grand opening of the Cohen Center for Recovery From Complex Chronic Illnesses (CoRE), providing clinical care for patients with conditions such as long Lyme disease/Lyme+, long COVID, and other infection-associated complex chronic illnesses such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Ehlers-Danlos syndrome (EDS).

10 Oct 2024

Bed availability influences critical care admissions after surgery

Bed availability is a "significant" factor in determining whether or not a patient is admitted to a critical care bed after surgery, questioning whether some are getting the care they need, a new study from researchers at UCL and UCLH has found for the first time.

10 Oct 2024

Skin pigmentation may affect drug efficacy and safety

Skin pigmentation may act as a "sponge" for some medications, potentially influencing the speed with which active drugs reach their intended targets, a pair of scientists report in a perspective article published in the journal Human Genomics.

10 Oct 2024

Dual immunotherapy plus chemotherapy shows promise for specific lung cancer patients

Researchers from The University of Texas MD Anderson Cancer Center have demonstrated that patients with metastatic non-squamous non-small cell lung cancer (NSCLC) harboring specific mutations in the STK11 and/or KEAP1 tumor suppressor genes were more likely to benefit from adding the immunotherapy tremelimumab to a combination of durvalumab plus chemotherapy to overcome treatment resistance typically seen in this patient population.

9 Oct 2024

Incorrect arm positioning inflates blood pressure readings, risking misdiagnosis

Incorrect arm positioning during blood pressure measurement can overestimate readings, potentially leading to misdiagnosis and overtreatment of hypertension. Proper arm support is essential for accuracy.

8 Oct 2024

Concerns rise over increased industry sponsorship in cancer clinical trials

A growing reliance on industry-sponsored cancer clinical trials in the United States is a reason for concern, say researchers from the UNC Lineberger Comprehensive Cancer Center.

8 Oct 2024

Heat stress impacts development of babies during critical early years

Exposure to high levels of heat may both impact the growth of fetuses during pregnancy and infants up to the age of two, a new analysis suggests.

8 Oct 2024

Electro-acupuncture shows promise in obesity management

A team of scientists led by Nanyang Technological University Singapore (NTU Singapore) and Hong Kong University (HKU) has found evidence that electro-acupuncture - a form of traditional Chinese medicine (TCM) treatment - could be used to manage obesity.

8 Oct 2024

Doxycycline increases antimicrobial resistance in the gut without disrupting microbiome diversity

Doxycycline post-exposure prophylaxis increases tetracycline resistance genes in the gut, without significantly affecting microbiome diversity in men who have sex with men and transgender women.

7 Oct 2024

Researchers discover effective treatment strategy for lethal glioblastoma

Glioblastoma (GBM) is the most lethal brain tumor, with a median survival rate of merely 12-16 months after diagnosis. Despite surgical, radiation and chemotherapy treatments, the two-year survival rate for GBM patients is less than 10%.

7 Oct 2024

Less is more in octreotide therapy for esophageal variceal hemorrhage

Researchers at the Medical University of South Carolina revealed the need to clarify current treatment guidelines for octreotide therapy following an esophageal variceal hemorrhage in a recent study from the American Journal of Medical Sciences.

7 Oct 2024

New insights on 5-fluorouracil's mechanism in different cancers

Study reveals the drug, 5-fluorouracil, acts differently in different types of cancer — a finding that could help researchers design better drug combinations.

7 Oct 2024

Early blood test can predict treatment response and survival prospects in metastatic prostate cancer

A blood test, performed when metastatic prostate cancer is first diagnosed, can predict which patients are likely to respond to treatment and survive the longest.

7 Oct 2024

One-dose HPV vaccination could eliminate cervical cancer in Canada

Canadian vaccination programs could switch to a 1-dose gender-neutral human papillomavirus (HPV) vaccination approach and eliminate cervical cancer, suggests new modeling in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.240787.

7 Oct 2024

Researchers reveal mechanisms of how CDK12 alterations drive prostate cancer development

When researchers at the University of Michigan Rogel Cancer Center first identified a new subtype of aggressive prostate cancer, they knew they needed to understand how this genetic alteration was driving cancer and how to target it with treatment.

4 Oct 2024

New drug could extend the lives of breast cancer patients

LMU researchers have successfully tested a new drug which can significantly extend the lives of breast cancer patients.

4 Oct 2024

Clinical Trial News and Research

Distinct immune profiles linked to adverse reactions from immunotherapy

Emory University researchers shift focus to neuroinflammation in Alzheimer's treatment

Multidisciplinary approach improves quality of life in functional movement disorders

New study reveals unique metabolic function of lung-resident NK immune cells

Mount Sinai launches new center for complex chronic illnesses

Bed availability influences critical care admissions after surgery

Skin pigmentation may affect drug efficacy and safety

Dual immunotherapy plus chemotherapy shows promise for specific lung cancer patients

Incorrect arm positioning inflates blood pressure readings, risking misdiagnosis

Concerns rise over increased industry sponsorship in cancer clinical trials

Heat stress impacts development of babies during critical early years

Electro-acupuncture shows promise in obesity management

Doxycycline increases antimicrobial resistance in the gut without disrupting microbiome diversity

Researchers discover effective treatment strategy for lethal glioblastoma

Less is more in octreotide therapy for esophageal variceal hemorrhage

New insights on 5-fluorouracil's mechanism in different cancers

Early blood test can predict treatment response and survival prospects in metastatic prostate cancer

One-dose HPV vaccination could eliminate cervical cancer in Canada

Researchers reveal mechanisms of how CDK12 alterations drive prostate cancer development

New drug could extend the lives of breast cancer patients

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