Protein C News and Research

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Innovative synthetic technique opens door to new world of cutting-edge medicinal compounds

In pharmacology, not all molecular structures are created equal. Some frameworks are overrepresented in nature, making them especially attractive to scientists on the hunt for more effective drugs.

4 Jul 2018

Researchers investigate role of MTSS1 protein in neuron branch development

A protein called "MetastasisMetastasis-suppressor 1"activates one pathway and inhibits another competing pathway, thus playing a dual role that determines how neuron branches in the brain form, according to research published in the journal Cell Reports.

4 Jul 2018

Specific type of satellite RNA induces breast cancer, shows study

Only some of us have satellite TV in our homes, but all of us have satellite DNA in cells in our bodies. Working copies of satellite DNA are high in certain types of cancer, such as breast and ovarian.

4 Jul 2018

Researchers develop switch that can control genome editing

Researchers have developed a biological switch that reliably triggers protein expression and enables the control of genome editing tools.

3 Jul 2018

Mayo researchers determine how DNA repair protein gets to the site of damage

Damage to DNA is a daily occurrence but one that human cells have evolved to manage. Now, in a new paper published in Nature Structural & Molecular Biology, Mayo researchers have determined how one DNA repair protein gets to the site of DNA damage. The authors say they hope this discovery research will help identify new therapies for ovarian cancer.

3 Jul 2018

Researchers find elevated biomarkers of brain injury after high-acceleration head impacts

Researchers from the University of Michigan found that serum levels of two biomarkers of traumatic brain injury, tau and ubiquitin C-terminal hydrolase L1, are elevated following high-acceleration head impacts, even when there is no clinical diagnosis of concussion.

3 Jul 2018

Increase in marker of inflammation from mid to late life linked with dementia

Researchers at Johns Hopkins have added to evidence that rising and chronic inflammation as measured by a biomarker in the blood in middle and late age are linked to visible structural changes in the brains of people with poor cognition and dementia.

2 Jul 2018

Low-dose aspirin may reduce amyloid plaques in the brain, study shows

A regimen of low-dose aspirin potentially may reduce plaques in the brain, which will reduce Alzheimer's disease pathology and protect memory, according to neurological researchers at Rush University Medical Center, who published the results of their study today in the July issue of The Journal of Neuroscience.

2 Jul 2018

Researchers identify molecular mechanism leading to cortical malformation from brain-only mutations

Focal malformations of cortical development are a heterogeneous group of brain cortical abnormalities.

2 Jul 2018

Novel sensing technology enables live and super-sensitive monitoring of biomarkers

The human body is an extremely complex molecular machine, the details of which can be followed through certain substances; so-called biomarkers.

2 Jul 2018

Established lung fibrosis can be reversed using diabetes drug treatment

Researchers at the University of Alabama at Birmingham have shown - for the first time - that established lung fibrosis can be reversed using a drug treatment that targets cell metabolism.

2 Jul 2018

Cilia appears to play key role in formation of melanoma

Most cells in the human body have a cilium, a slender cell protuberance that picks up signals from the cell's external environment.

2 Jul 2018

Study finds that several existing anti-cancer drugs may work in part by binding to RNA

Bolstering the notion that RNA should be considered an important drug-discovery target, scientists at Scripps Research have found that several existing, FDA-approved anti-cancer drugs may work, in part, by binding tightly to RNA, the regulators of the basic activities of life within cells.

30 Jun 2018

KU Cancer Center launches clinical trial to eliminate radiation therapy for HER2-positive breast cancer

Researchers at The University of Kansas Cancer Center have launched a clinical trial that eliminates radiation from the treatment protocol for an invasive type of breast cancer that accounts for one-fifth of all breast cancer patients.

30 Jun 2018

Timing may be key to evading destruction for bacteria facing antibiotics

For bacteria facing a dose of antibiotics, timing might be the key to evading destruction. In a series of experiments, Princeton researchers found that cells that repaired DNA damaged by antibiotics before resuming growth had a much better chance of surviving treatment.

30 Jun 2018

City of Hope receives $3.7 million from CIRM to develop phase 1 glioblastoma trial

The California Institute for Regenerative Medicine board has awarded City of Hope $3.7 million to develop a phase 1 clinical trial for glioblastoma patients that will genetically engineer their stem cells to better tolerate chemotherapy's side effects, allowing them to receive higher doses of the therapy.

30 Jun 2018

Research shows why new cancer therapies fail to work on some patients

University of Otago research provides insights into an underlying mechanism that could explain why new cancer therapies to help treat metastatic melanoma do not always work on patients, paving the way for predicting which patients will benefit from certain drugs.

30 Jun 2018

Protein C News and Research

Innovative synthetic technique opens door to new world of cutting-edge medicinal compounds

Researchers investigate role of MTSS1 protein in neuron branch development

Specific type of satellite RNA induces breast cancer, shows study

Researchers develop switch that can control genome editing

Mayo researchers determine how DNA repair protein gets to the site of damage

Researchers find elevated biomarkers of brain injury after high-acceleration head impacts

Increase in marker of inflammation from mid to late life linked with dementia

Low-dose aspirin may reduce amyloid plaques in the brain, study shows

Researchers identify molecular mechanism leading to cortical malformation from brain-only mutations

Novel sensing technology enables live and super-sensitive monitoring of biomarkers

Established lung fibrosis can be reversed using diabetes drug treatment

Cilia appears to play key role in formation of melanoma

Study finds that several existing anti-cancer drugs may work in part by binding to RNA

KU Cancer Center launches clinical trial to eliminate radiation therapy for HER2-positive breast cancer

Timing may be key to evading destruction for bacteria facing antibiotics

City of Hope receives $3.7 million from CIRM to develop phase 1 glioblastoma trial

Research shows why new cancer therapies fail to work on some patients

Tau protein allows microtubules to grow and remain dynamic, shows study

Scientists focus on critical regulatory protein to find clues on cancer, neurodegenerative diseases

Enzyme TLK2 could serve as potential therapies for breast cancer, brain condition

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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