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Artificial circular RNAs found to bypass cellular antiviral responses

Researchers produced artificial circular ribonucleic acid sponges in a permuted intron-exon system and showed that these did not activate innate immunity.

29 Apr 2022

Study reports an orally available SARS-CoV-2 Mpro inhibitor with potent in vivo antiviral activity

Researchers examined the efficiency of the main protease (Mpro) inhibitor against SARS-CoV-2.

29 Apr 2022

Study shows polysaccharides of seaweed and abalone inhibit SARS-CoV-2 in vitro

A new study published in Marine Drugs evaluated the inhibitory effect of three polysaccharides, crude polysaccharide from Hizikia fusiforme (CPHF), crude polysaccharide from Sargassum horneri (CPSH), and crude polysaccharide from abalone viscera (CPAV) on the propagation of SARS-CoV-2 in vitro.

28 Apr 2022

Researchers create 3D in vitro model that reveals the origins of human spine

The spinal column is the central supporting structure of the skeleton in all vertebrates. Not only does it provide a place for muscles to attach, it also protects the spinal cord and nerve roots. Defects in its development are known to cause rare hereditary diseases.

28 Apr 2022

Evaluating nano alum as a substitute for conventional alum-based vaccine adjuvant

Researchers evaluated the performance and safety of nano alum adjuvant as next-generation coronavirus disease 2019 (COVID-19) vaccine antigens.

28 Apr 2022

Identification of a SARS-CoV-2 neutralizing human monoclonal antibody with a remarkable broad-spectrum neutralization and protection efficacy

Researchers identified a human monoclonal antibody (mAb), 87G7, with in vitro neutralizing activity against several SARS-CoV-2 VOCs, including Alpha, Beta, Gamma, Delta, and Omicron.

28 Apr 2022

A cigarette smoke compound affects cartilage homeostasis

Cigarette smoke has been shown to deleteriously affect human health. For example, degenerative disc diseases are increasingly linked to cigarette smoking.

28 Apr 2022

Researchers demonstrate the efficiency of T-cell immune response against the Omicron variant

Scholars from HSE University and the RAS Institute of Bioorganic Chemistry have demonstrated the efficiency of T-cell immune response against the Omicron variant of SARS-CoV-2.

28 Apr 2022

The preclinical potential of a herb used in traditional Chinese medicine for the treatment of COVID-19

In a study published in Cells, researchers have been investigating the effects of this extract for use against COVID-19.

27 Apr 2022

UNC study introduces a novel opportunity to democratize obstetric ultrasound

Establishing accurate gestational age with ultrasound early in pregnancy is essential to delivering high-quality care.

26 Apr 2022

Evidence of increased intrinsic cleavability of SARS-CoV-2 Omicron spike protein by host cell furin

Researchers conducted an in vitro analysis to assess the host cell furin-mediated cleavability of the spike protein of the SARS-CoV-2 Omicron (B.1.529) variant.

26 Apr 2022

Nanobody effectively neutralizes pseudotyped ancestral SARS-CoV-2 and Omicron spike proteins

Researchers identified a nanobody inhibiting SARS-CoV-2 variants.

26 Apr 2022

Study explores SARS-CoV-2 antibody responses in mild COVID-19 cases

In a new study, researchers evaluated antibody responses in mild cases of coronavirus disease 2019.

26 Apr 2022

Quantum dot biomimetic for SARS-CoV-2 examines neurovascular dysregulation related to brain inflammation

Researchers developed SARS-CoV-2 virus-like nanoparticles with a quantum dots core.

26 Apr 2022

CN Bio introduces PhysioMimix NASH ‘in-a-box’ reagent kit

First product within new ‘in-a-box’ range, which harnesses next-generation, human-relevant Liver-on-a-Chip technology to improve the accuracy and efficiency of NASH drug discovery.

From CN Bio 26 Apr 2022

The potency of halicin against the main protease of SARS-CoV-2

A new paper published in Current Research in Chemical Biology discusses the potential of a molecule called halicin against SARS-CoV-2.

26 Apr 2022

Role of complement factor H-related protein 5 in venous thromboembolism and COVID-19

A new study discussed the role of complement factor H-related protein 5 (CFHR5) in venous thromboembolism (VTE) patients and hospitalized COVID-19 patients.

25 Apr 2022

Marine resources could be promising drug candidates against SARS-CoV-2 Omicron

A recent review paper, published in the MDPI’s specialized journal COVID, highlights key features of the Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – and examines the potential and roadblocks in using renewable marine resources in the fight against the coronavirus disease 2019 (COVID-19).

24 Apr 2022

Quercetin and other plant flavonols show anti-SARS-CoV-2 activity

A new study discusses the potential of certain plant compounds to block SARS-CoV-2 replication within host cells.

24 Apr 2022

Study shows safety, feasibility of intranasal milk therapy for infants with intraventricular hemorrhage

A new study demonstrates that intranasal human milk is a safe and feasible intervention for intraventricular hemorrhage, a serious cause of morbidity in preterm infants.

22 Apr 2022

in vitro News and Research

Artificial circular RNAs found to bypass cellular antiviral responses

Study reports an orally available SARS-CoV-2 Mpro inhibitor with potent in vivo antiviral activity

Study shows polysaccharides of seaweed and abalone inhibit SARS-CoV-2 in vitro

Researchers create 3D in vitro model that reveals the origins of human spine

Evaluating nano alum as a substitute for conventional alum-based vaccine adjuvant

Identification of a SARS-CoV-2 neutralizing human monoclonal antibody with a remarkable broad-spectrum neutralization and protection efficacy

A cigarette smoke compound affects cartilage homeostasis

Researchers demonstrate the efficiency of T-cell immune response against the Omicron variant

The preclinical potential of a herb used in traditional Chinese medicine for the treatment of COVID-19

UNC study introduces a novel opportunity to democratize obstetric ultrasound

Evidence of increased intrinsic cleavability of SARS-CoV-2 Omicron spike protein by host cell furin

Nanobody effectively neutralizes pseudotyped ancestral SARS-CoV-2 and Omicron spike proteins

Study explores SARS-CoV-2 antibody responses in mild COVID-19 cases

Quantum dot biomimetic for SARS-CoV-2 examines neurovascular dysregulation related to brain inflammation

CN Bio introduces PhysioMimix NASH ‘in-a-box’ reagent kit

The potency of halicin against the main protease of SARS-CoV-2

Role of complement factor H-related protein 5 in venous thromboembolism and COVID-19

Marine resources could be promising drug candidates against SARS-CoV-2 Omicron

Quercetin and other plant flavonols show anti-SARS-CoV-2 activity

Study shows safety, feasibility of intranasal milk therapy for infants with intraventricular hemorrhage

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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