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Altered activity in receptor pair points to further complexity in schizophrenia pathology

Researchers at the University of Pennsylvania School of Medicine, in collaboration with scientists at the City University of New York, have identified a striking dysregulation in neuronal receptor activity in the postmortem brain tissue from patients with schizophrenia.

18 Jun 2006

New roles for growth factors

During embryonic development, nerve cells hesitantly extend tentacle-like protrusions called axons that sniff their way through a labyrinth of attractive and repulsive chemical cues that guide them to their target.

18 Jun 2006

Sonic hedgehog may help overcome problems associated with FGF2 and VEGF therapy

The newest concept for treating coronary artery disease is to induce hearts to grow their own new blood vessels to bypass damaged tissue or clogged arteries.

18 Jun 2006

From DNA to RNA to protein

Of the thousands of proteins produced in our cells, few are as important as the enzyme RNA polymerase (RNAP), which has the unique ability to faithfully copy genetic information from DNA.

18 Jun 2006

Fly research sheds light on sleep regulation and its role in memory

Researchers at the University of Pennsylvania School of Medicine have discovered that a brain region previously known for its role in learning and memory also serves as the location of sleep regulation in fruit flies.

18 Jun 2006

Transcription factors act not only in isolation to regulate distinct sets of genes

Scientists eager to help develop a new generation of pharmaceuticals are studying cellular proteins called transcription factors, which bind to upstream sequences of genes to turn the expression of those genes on or off.

18 Jun 2006

Discovery of gene behind iron accumulation in brain has implications for Parkinson's, Alzheimer's

Oregon Health & Science University researchers have identified the gene behind a group of rare, progressive childhood disorders caused by an abnormal buildup of iron in the brain.

18 Jun 2006

Protein represents new target in the treatment of diabetes

According to a new study elevated levels of a molecule called RBP4 (retinol binding protein 4) forecast the early stages of the development of insulin resistance, a major cause of type 2 diabetes as well as cardiovascular disease and metabolic syndrome.

18 Jun 2006

Elevation of fat-derived molecule foretells early insulin resistance

A study in the June 15 issue of The New England Journal of Medicine (NEJM) reveals that elevated levels of a molecule called RBP4 (retinol binding protein 4) can foretell early stages in the development of insulin resistance.

14 Jun 2006

Circulating bone-marrow derived cells do not contribute to egg formation

Ovulated egg cells, or oocytes, in adult female mice are not formed from germ cells in the blood or bone marrow.

14 Jun 2006

Scientists watch the behavior of a single gene in real time

Scientists at the Albert Einstein College of Medicine of Yeshiva University have observed for the first time that gene expression can occur in the form of discrete "pulses" of gene activity.

14 Jun 2006

Scientists reveal two paths of neurodegeneration

Wiring the developing brain is like creating a topiary garden. Shrubs don't automatically assume the shape of ornamental elephants, and neither do immature nerve cells immediately recognize the "right" target cell.

14 Jun 2006

Evidence of RNA in structures essential to cell division

Evidence for the first time that centrosomes, which play a key role in cell division, may carry their own genetic machinery, answering a controversial question of long standing.

14 Jun 2006

AUA podium session on stone disease

2-phase randomized crossover study on a constant diet with calcium carbonate supplementation at 250 mg 4 times daily.

13 Jun 2006

New test identifies patients who benefit from targeted cancer drugs

New lab test accurately identified patients who would benefit from treatment with the molecularly-targeted anti-cancer therapies gefitinib (Iressa, AstraZeneca) and erlotinib (Tarceva, Genentech).

13 Jun 2006

Mechanism for neurodenegerative diseases linked to transport proteins

Hampering the transport of proteins within cells may underlie several adult-onset neurodegenerative diseases, such as Huntington's, ALS and Kennedy disease. Understanding how this cell transport is blocked in these diseases may offer targets for future therapy.

9 Jun 2006

Research explains how pathogenic bacteria evolved over millions of years

Bacteria like Salmonella have a complicated immune system that helps them recognize and isolate foreign DNA trying to invade their cell membrane, according to a University of Washington-led study in the June 8 issue of Science Express.

9 Jun 2006

New era in cancer prevention

Nearly two decades ago, researchers at the National Cancer Institute (NCI) and other institutions began searching for the underlying causes of cervical cancer.

9 Jun 2006

Protein called Elk-1appears to play role in neurodegeneration and schizophrenia

Pprotein called Elk-1 interacts with mitochondria, the energy storehouse of a cell, suggesting that this protein - typically active in the nucleus - could play a role in cell death and mitochondria-related diseases such as neurodegeneration and schizophrenia.

9 Jun 2006