Protein C News and Research

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Continuous tracking of melanoma cell invasion helps scientists explain key regulators of metastasis

A team of Italian scientists reported this week that blocking the interaction between urokinase receptor (uPAR) and formyl peptide receptor type 1 (FPR1) suppresses the ability of melanoma cells to migrate, invade through an extracellular matrix, and to burrow through a layer of endothelial cells.

13 Mar 2018

Study sheds new light on viral replication

Viruses are intracellular parasites that cause disease by infecting the cells in the body and, in a study published today in Nature Microbiology, researchers at Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine showed how a common virus hijacks a host cell's protein to help assemble new viruses before they are released.

13 Mar 2018

Study identifies two new biomarkers for common form of childhood cancer

Two new biomarkers for a type of cancer in children called neuroblastoma have been identified in a study published in the journal Cancer Cell. The findings are expected to have immediate significance for disease prognosis, and eventually also for treatment.

13 Mar 2018

International research consortium identifies 22 new genetic risk factors for stroke

An international research consortium studying 520,000 individuals from around the world has identified 22 new genetic risk factors for stroke, thus tripling the number of gene regions known to affect stroke risk.

13 Mar 2018

Southern Research scientists target mutated protein to combat prostate cancer

Southern Research scientists are exploring how a mutated protein implicated in prostate cancer plays a role in the development of the disease and whether it holds a key to better treatment outcomes.

13 Mar 2018

Protein pathways linked to heart disease, diabetic complications identified in patients with diabetes

Protein pathways that are closely linked to changes in both triglyceride and hemoglobin A1c levels in diabetic patients have been identified in new research by the Intermountain Medical Center Heart Institute in Salt Lake City.

12 Mar 2018

Study validates Xpresys Lung 2 for differential diagnosis of early stage lung cancer

Integrated Diagnostics today announced the e-publication of full results of a large prospective clinical trial validating its Xpresys Lung 2 in the peer-reviewed medical journal CHEST¸ the official journal of the American College of Chest Physicians, titled: Assessment of Plasma Proteomics Biomarker’s Ability to Distinguish Benign From Malignant Lung Nodules: Results of the PANOPTIC trial.

12 Mar 2018

Researchers find specific cellular structures that orchestrate rapid immunologic memory

With every infection or vaccination, memory cells form that the body uses to remember the pathogen. This has been known for decades - but the structure of this cellular immunologic memory has previously proven impossible to pin down.

9 Mar 2018

Impaired transport processes in neurons contribute to neurodegenerative disorders

Two partners have to find their way to each other in order to transport substances to the remote ends of special nerve fibers to maintain their function. If this partnering process is disturbed, the cells may die in the worst case, resulting in neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) or spinal muscular atrophy.

9 Mar 2018

Novel screening tool aids search for curative kidney treatment

Researchers have developed a screening tool for identifying compounds that restore functionality of the protein that is dysfunctional in Alport syndrome.

9 Mar 2018

Surprise discovery may lead potential treatment for multiple sclerosis

A surprise finding by medical scientists may lead to the development of a possible treatment for multiple sclerosis (MS).

9 Mar 2018

Mice study illustrates potential risks associated with prion transmission

Familial human prion diseases are passed within families and are associated with 34 known prion protein mutations.

9 Mar 2018

TSRI researchers show path to developing treatments for Charcot-Marie-Tooth disease

Scientists at The Scripps Research Institute have now shown a path to developing treatments for disease subtype CMT2D.

8 Mar 2018

Discovery may lead to effective research and better treatments for Ebola, other viral diseases

University of Alberta researchers have found the Ebola polymerase (enzyme), which may lead to more effective research and better treatments for the often fatal infection, and other related viral diseases.

8 Mar 2018

Study shows how fly's circadian clock network takes temperature cues to control sleep

Circuits in the brain act as an internal clock to tell us it is time to sleep and to control how long we then stay asleep. A new study in flies suggests a part of that clock constantly monitors changes in external temperature and integrates that information into the neural network controlling sleep.

8 Mar 2018

Blood samples can soon reflect a person’s lifestyle

People who use moist snuff 'snus' have significantly higher levels of the protein cornulin in their blood than non-snusers. This previously unknown relationship was found in a new study from Umeå University, Sweden. Whether higher levels per se increase the risk of disease has, however, not yet been clarified.

8 Mar 2018

Researchers find link between increased proteostasis and immortality of stem cells

Stem cells are considered to be immortal in culture and, therefore, of great interest for aging research. This immortality is regulated by increased proteostasis, which controls the quality of proteins.

8 Mar 2018

Newly-discovered hereditary mutation leads to increased production of EPO in the blood

A newly-discovered hereditary mutation is responsible for an increased production of erythropoietin (EPO) in the blood.

8 Mar 2018

Study reveals key function of ALS-linked protein

The protein FUS, whose mutation or disruption causes many cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), works as a central component of one of the most important regulatory systems in cells, according to a new study in Molecular Cell from scientists at Johns Hopkins Bloomberg School of Public Health.

8 Mar 2018

Boosting the brain's immune cells may prevent or reduce severity of Alzheimer's disease

Sanford Burnham Prebys Medical Research Institute researchers have published two new studies in Neuron that describe how TREM2, a receptor found on immune cells in the brain, interacts with toxic amyloid beta proteins to restore neurological function.

8 Mar 2018

Protein C News and Research

Continuous tracking of melanoma cell invasion helps scientists explain key regulators of metastasis

Study sheds new light on viral replication

Study identifies two new biomarkers for common form of childhood cancer

International research consortium identifies 22 new genetic risk factors for stroke

Southern Research scientists target mutated protein to combat prostate cancer

Protein pathways linked to heart disease, diabetic complications identified in patients with diabetes

Study validates Xpresys Lung 2 for differential diagnosis of early stage lung cancer

Researchers find specific cellular structures that orchestrate rapid immunologic memory

Impaired transport processes in neurons contribute to neurodegenerative disorders

Novel screening tool aids search for curative kidney treatment

Surprise discovery may lead potential treatment for multiple sclerosis

Mice study illustrates potential risks associated with prion transmission

TSRI researchers show path to developing treatments for Charcot-Marie-Tooth disease

Discovery may lead to effective research and better treatments for Ebola, other viral diseases

Study shows how fly's circadian clock network takes temperature cues to control sleep

Blood samples can soon reflect a person’s lifestyle

Researchers find link between increased proteostasis and immortality of stem cells

Newly-discovered hereditary mutation leads to increased production of EPO in the blood

Study reveals key function of ALS-linked protein

Boosting the brain's immune cells may prevent or reduce severity of Alzheimer's disease

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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