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Protein-dependent "switch" regulates intracellular trafficking in epithelial cells

With findings highlighted on a recent cover of Developmental Cell , researchers at Weill Cornell Medical College in New York City have shed important new light on key trafficking mechanisms within epithelial cells. Epithelial cells line the outside of nearly all organs.

12 Dec 2007

Biodegradable polymers with neurotransmitters promote nerve regrowth

Research reported December 11 in the journal Advanced Materials describes a potentially promising strategy for encouraging the regeneration of damaged central nervous system cells known as neurons.

12 Dec 2007

Exercise testing to predict mitral regurgitation

In as many as one in five people over age 55, when the heart contracts to send blood around the body, some degree of backward leakage occurs across the mitral valve, a condition known as mitral regurgitation (MR).

12 Dec 2007

Novel technique using computer modeling identifies potential side effects of pharmaceuticals

Early identification of adverse effects of drugs before they are tested in humans is crucial in developing new therapeutics, as unexpected effects account for a third of all drug failures during the development process.

12 Dec 2007

Kids more active when playground well equipped

Children play harder and longer when their child-care centers provide portable play equipment such as balls and jump ropes, more opportunities for active play and physical activity training and education for staff and students, according to researchers at the University of North Carolina at Chapel Hill School of Public Health.

12 Dec 2007

Epigenomic test that could improve treatment for specific gastric cancers

A study by researchers at the John Wayne Cancer Institute at Saint John's Health Center in a recent issue of Journal of Clinical Oncology identifies activation of the enzyme COX-2 in gastric cancer tumors as a prognostic indicator for poor outcome.

12 Dec 2007

FDA and Pharsight continue to collaborate under CRADA

Pharsight Corporation has provided an update on its Cooperative Research and Development Agreement (CRADA) with the Food and Drug Administration's (FDA) Center for Drug Evaluation and Research (CDER).

12 Dec 2007

Exercise testing may help predict seriousness of mitral regurgitation

12 Dec 2007

SEBIA joins EDMA corporate membership

EDMA , the European Diagnostic Manufacturers Association welcomes SEBIA as new corporate affiliate, bringing the Association's overall membership up to 33 major IVD companies and 21 National Associations.

12 Dec 2007

Bosutinib safe, effective for chronic myelogenous leukemia

A new drug for chronic myelogenous leukemia works for patients who have developed resistance to frontline therapy and causes fewer side effects than other medications in its class, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports at the 49th annual meeting of the American Society of Hematology.

12 Dec 2007

Data confirm Dasatinib's effectiveness in resistant chronic myelogenous leukemia

Updated clinical trial results show that the drug dasatinib (Sprycel) continues to be highly effective in patients with chronic myelogenous leukemia who were unable to tolerate Gleevec or who developed resistance to it, reports a team led by researchers at Dana-Farber Cancer Institute.

12 Dec 2007

$15 million boost for malaria treatment in rural Tanzania

The Global Program on Malaria at the Johns Hopkins Bloomberg School of Public Health's Center for Communication Programs (CCP) received a $15 million grant to develop communication strategies to prevent and treat malaria in rural Tanzania.

12 Dec 2007

Red meat and cancer

New findings provide evidence that people who eat a lot of red and processed meats have greater risk of developing bowel and lung cancer than people who eat small quantities.

12 Dec 2007

Cancer cell line developed that is resistant to new cancer therapy

A cancer cell line that is resistant to one of the newest classes of cancer treatments has been developed by researchers who already are using it to determine what else to give patients when this happens.

12 Dec 2007

Effects of space radiation on astronauts

Cold Spring Harbor Laboratory (CSHL) scientists recently led a team of researchers to study potential effects of space radiation on astronauts. The results of their study are revealing and will provide the foundation for ensuring the safety of crew members participating in long distance space travel.

12 Dec 2007