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Hap1 protein could lead to future drug targets for eating disorders

Researchers have discovered how the protein Hap1, which is abundant in the brain's hypothalamus, serves as the link between circulating insulin in the blood and the neural circuitry that controls feeding behavior in mice.

16 Apr 2006

First gene therapy human trial in the United States for a form of muscular dystrophy under way

The clinical trial for Duchenne muscular dystrophy (DMD) tests the safety and effectiveness of a therapy that was developed over two decades by scientists at the University of North Carolina Chapel Hill's School of Medicine and the University of Pittsburgh.

16 Apr 2006

Doses of DNA-gene-coated gold particles protect against harmful protein implicated in Alzheimer's disease

Doses of DNA-gene-coated gold particles protect mice against a protein implicated in Alzheimer's disease, researchers at UT Southwestern Medical Center have found.

16 Apr 2006

Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6

A novel growth factor significantly improves the ability of specialized stem cells derived from human fat to be transformed into cartilage cells, according to Duke University Medical Center and Pratt School of Engineering researchers.

16 Apr 2006

Mad cow disease appears again in Canadian cattle

According to Canada's Food Inspection Agency (CFIA), tests have confirmed that a six-year-old dairy cow in the Canadian province of British Columbia suffered from mad cow disease.

16 Apr 2006

Reversing cell division has implications for the treatment of cancer

A scientist in the United States has apparently found a way to reverse the process of cell division.

13 Apr 2006

The Notch effect steers stem cells into cells of the nervous system

Stem cell scientists at the University of Edinburgh have discovered that Notch, a protein first discovered more than 80 years ago in the fruit fly, directs unspecialized embryonic stem cells to become cells of the nervous system.

13 Apr 2006

Researchers suggest drug could block metastasis or reduce pain for bone cancer patients

An international research team has identified what may be a critical molecule in the ability of tumours to metastasize -- or spread -- into bone.

13 Apr 2006

Proteomic mass spectrometry helps identify viruses

Scientists have used mass spectrometry for decades to determine the chemical composition of samples but rarely has it been used to identify viruses, and never in complex environmental samples.

13 Apr 2006

Analysis of different sweeteners and sweet substances

The most important factor in what kind of sweetener people prefer has little to do with how sweet it tastes. Rather, it has more to do with other tastes in the sweetener, such as bitterness or sourness, new research suggests.

13 Apr 2006

IL-25 both promotes and limits inflammatory diseases

The same signal responsible for promoting the type of immune responses that cause asthma and allergy can also limit the type of inflammation associated with debilitating diseases like inflammatory bowel disease, arthritis and multiple sclerosis, according to researchers from the University of Pennsylvania School of Veterinary Medicine.

13 Apr 2006

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

Huntington disease (HD) is a degenerative brain disease in which brain cells called neurons die as a result of aggregations of the polyQ-huntingtin protein.

13 Apr 2006

Research provides clues to obesity's cause

Hot fudge sundaes and french fries aside, new research suggests obesity is due at least in part to an attraction between leptin, the hormone that signals the brain when to stop eating, and a protein more recently associated with heart disease.

13 Apr 2006

Dasatinib provides significant benefit in chronic myeloid leukemia patients resistant to Gleevec

A study led by researchers from the Howard Hughes Medical Institute has found that dasatinib provides significant benefit in chronic myeloid leukemia (CML) patients resistant to Gleevec. (imatinib), according to a study presented during the 97th Annual Meeting of the American Association for Cancer Research.

11 Apr 2006

Environmental change and viral mutations combine to fuel outbreaks of a deadly mosquito-borne disease

Environmental change and viral mutations have combined to fuel outbreaks of a deadly mosquito-borne disease that have plagued South and Central America for the last 100 years, a new study by University of Texas Medical Branch at Galveston (UTMB) and Colorado State University researchers reports.

11 Apr 2006

Researchers identify the role of a protein in hemoglobin gene silencing

Virginia Commonwealth University Massey Cancer Center researchers have identified the role of a protein in hemoglobin gene silencing that may one day be a potential target for the treatment of genetic blood disorders like sickle-cell anemia and beta-thalassemia on the molecular level.

11 Apr 2006

New model of p53 regulation has important implications for the development of anticancer drugs

Genetically engineered mice convinced scientists at the Salk Institute for Biological Studies that it was time to overhaul widely held beliefs about how a powerful tumor suppressor called p53 is controlled in cells. Their new model of p53 regulation has important implications for the development of anticancer drugs.

11 Apr 2006

Researchers determine factors that turn on protein production in bacteria

In the study, published in the journal Molecular Cell, researchers Sean Studer and Simpson Joseph in UCSD's Department of Chemistry and Biochemistry report how the messenger RNA instructions to make a protein are unfolded in a bacterial cell, so that they can be read by the cell's protein-making machinery.

11 Apr 2006

Research explains why recipients of growth hormone therapy may develop colon polyps

The use of growth hormone therapy has been linked in some people to the development of colon polyps, a possible precursor to colorectal cancer - but medical researchers have debated the extent of a cancer risk.

11 Apr 2006

Targeted mutations in mice uncover two key molecular events linked to learning

Johns Hopkins researchers have used mouse mutants to define critical steps involved in learning basic motor skills. The study focuses on the behavior of two proteins and the specific steps they take to control a neuron's ability to learn by adapting to signals from other nerve cells.

11 Apr 2006

G Protein News and Research

Hap1 protein could lead to future drug targets for eating disorders

First gene therapy human trial in the United States for a form of muscular dystrophy under way

Doses of DNA-gene-coated gold particles protect against harmful protein implicated in Alzheimer's disease

Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6

Mad cow disease appears again in Canadian cattle

Reversing cell division has implications for the treatment of cancer

The Notch effect steers stem cells into cells of the nervous system

Researchers suggest drug could block metastasis or reduce pain for bone cancer patients

Proteomic mass spectrometry helps identify viruses

Analysis of different sweeteners and sweet substances

IL-25 both promotes and limits inflammatory diseases

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

Research provides clues to obesity's cause

Dasatinib provides significant benefit in chronic myeloid leukemia patients resistant to Gleevec

Environmental change and viral mutations combine to fuel outbreaks of a deadly mosquito-borne disease

Researchers identify the role of a protein in hemoglobin gene silencing

New model of p53 regulation has important implications for the development of anticancer drugs

Researchers determine factors that turn on protein production in bacteria

Research explains why recipients of growth hormone therapy may develop colon polyps

Targeted mutations in mice uncover two key molecular events linked to learning

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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