Protein C News and Research

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Research opens up new avenue to minimize risks of transplants

A bone marrow transplant is often the only therapy available to save leukemia patients, but the risk of complications is high. In spite of devoting considerable time and effort to finding a suitable donor, nearly half of all patients experience an unwanted reaction of their immune system, which often attacks their skin and liver and in up to 50% of cases the intestines.

21 Feb 2018

Penn study sheds new light on immune cell identity

Almost all cells in the human body have identical DNA sequences, yet there are 200-plus cell types with different sizes, shapes, and chemical compositions. Determining what parts of the genome are read to make protein and which are silenced is orchestrated by proteins called transcription factors.

21 Feb 2018

Researchers discover five new genetic changes that may increase pancreatic cancer risk

In what is believed to be the largest pancreatic cancer genome-wide association study to date, researchers at the Johns Hopkins Kimmel Cancer Center and the National Cancer Institute, and collaborators from over 80 other institutions worldwide discovered changes to five new regions in the human genome that may increase the risk of pancreatic cancer.

21 Feb 2018

Study finds novel therapeutic strategy that preserves neuromuscular synapses in ALS mouse model

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, causes lethal respiratory paralysis within several years of diagnosis. There are no effective treatments to slow or halt this devastating disease.

21 Feb 2018

Low protein levels linked to posture and gait problems in Parkinson’s, finds study

A new study has linked low levels of alpha-synuclein in the cerebrospinal fluid of patients with Parkinson’s to postural instability and gait difficulty.

21 Feb 2018

Bioactive compound limits collateral damage in the kidneys after heart attack

A heart attack triggers an acute inflammatory response at the damaged portion of the heart's left ventricle. If this acute inflammation lingers, it can lead to stretching of the ventricle and heart failure. The inflammation can claim another victim -- the kidneys.

21 Feb 2018

Clinical trial shows safety of promising TSRI stroke drug

A preliminary Phase 2 clinical trial has demonstrated that patients with acute ischemic stroke, the most common type of stroke, can safely tolerate high doses of 3K3A-APC, a promising anti-stroke drug invented at The Scripps Research Institute.

20 Feb 2018

Researchers target abnormal epigenetic mechanisms involved in childhood cancers

Several childhood cancer cell types show features of immature neural cells, and there is evidence suggesting that these tumors may arise from neural crest stem cells that underwent abnormal changes during embryonic development.

20 Feb 2018

Researchers discover potential new antimalarial treatment targets

Researchers have discovered crucial new processes that allow malaria parasites to escape red blood cells and infect other cells, offering potential new treatment targets.

20 Feb 2018

AbbVie and Voyager Therapeutics collaborate to develop new treatments for tauopathies

AbbVie, a global biopharmaceutical company, and Voyager Therapeutics, Inc., a clinical-stage gene therapy company, today announced that they have entered into an exclusive strategic collaboration and option agreement to develop and commercialize vectorized antibodies directed against tau for the treatment of Alzheimer's disease and other neurodegenerative diseases.

20 Feb 2018

Study describes new protection mechanisms to fight neurodegeneration in Parkinson's and Alzheimer's

A new research study reveals RAC1 protein could be a new therapeutic target to study the molecular mechanisms related to the neurodegenerative processes in Parkinson's disease.

20 Feb 2018

Brain's quality control process holds clues to obesity's roots

Deep in the middle of our heads lies a tiny nub of nerve cells that play a key role in how hungry we feel, how much we eat, and how much weight we gain. Around the clock, they produce a "grandfather" form of several hormones that help us regulate these crucial functions.

20 Feb 2018

Researchers aim to decipher molecular architecture of microtubule-organizing centers

Cell division is an intricately choreographed ballet of proteins and molecules that divide the cell. During mitosis, microtubule-organizing centers assemble the spindle fibers that separate the copying chromosomes of DNA.

20 Feb 2018

Scientists explore connection between bad sleep habits and stiff blood vessels

What do bad sleep habits and stiff blood vessels have in common? Nothing good, say scientists exploring what appears to be a direct connection between a circadian clock that isn't working as it should and an enzyme that promotes inflammation working overtime.

20 Feb 2018

Study: Diagnosis of celiac disease takes 3.5 years for patients who do not report GI symptoms

It takes an average of 3.5 years to diagnose celiac disease in patients who do not report gastrointestinal symptoms, a Loyola Medicine study has found.

19 Feb 2018

Autism could be predicted from blood or urine tests soon

Thousands of children are being diagnosed with autism on the basis of tests that are mainly based on the behaviour of the child and his or her responses to the tests and behavioural assessments. In short, there are no blood tests or urine tests that can be used to diagnose autism.

19 Feb 2018

Study reveals functional dynamics of ion channels

Most ion channels are very selective about the ions, which may or may not pass through them. They may be conductive for potassium ions and non-conductive for sodium ions or vice versa.

19 Feb 2018

Key protein involved in epigenetic regulation of gene expression guides skin cell renewal

Approximately once a month, our skin completely renews itself. If this highly coordinated process goes awry, it can lead to a variety of skin diseases, ranging from skin cancer to psoriasis.

19 Feb 2018

Lab-grown cerebellar cells may help explain how ASD develops at molecular level

Increasing evidence has linked autism spectrum disorder with dysfunction of the brain's cerebellum, but the details have been unclear. In a new study, researchers at Boston Children's Hospital used stem cell technology to create cerebellar cells known as Purkinje cells from patients with tuberous sclerosis complex, a genetic syndrome that often includes ASD-like features.

19 Feb 2018

Researchers uncover how excess calcium may influence development of Parkinson’s disease

Researchers have found that excess levels of calcium in brain cells may lead to the formation of toxic clusters that are the hallmark of Parkinson's disease.

19 Feb 2018

Protein C News and Research

Research opens up new avenue to minimize risks of transplants

Penn study sheds new light on immune cell identity

Researchers discover five new genetic changes that may increase pancreatic cancer risk

Study finds novel therapeutic strategy that preserves neuromuscular synapses in ALS mouse model

Low protein levels linked to posture and gait problems in Parkinson’s, finds study

Bioactive compound limits collateral damage in the kidneys after heart attack

Clinical trial shows safety of promising TSRI stroke drug

Researchers target abnormal epigenetic mechanisms involved in childhood cancers

Researchers discover potential new antimalarial treatment targets

AbbVie and Voyager Therapeutics collaborate to develop new treatments for tauopathies

Study describes new protection mechanisms to fight neurodegeneration in Parkinson's and Alzheimer's

Brain's quality control process holds clues to obesity's roots

Researchers aim to decipher molecular architecture of microtubule-organizing centers

Scientists explore connection between bad sleep habits and stiff blood vessels

Study: Diagnosis of celiac disease takes 3.5 years for patients who do not report GI symptoms

Autism could be predicted from blood or urine tests soon

Study reveals functional dynamics of ion channels

Key protein involved in epigenetic regulation of gene expression guides skin cell renewal

Lab-grown cerebellar cells may help explain how ASD develops at molecular level

Researchers uncover how excess calcium may influence development of Parkinson’s disease

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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