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Common cardiac sodium channel variant associated with sudden infant death in African Americans

Steve A.N. Goldstein and colleagues from the Pritzker School of Medicine in Chicago have found that a specific mutation, called S1103Y, in a heart protein known as SCN5A is associated with a dramatic, 24-fold increased risk of sudden infant death syndrome (SIDS) in African American infants.

7 Feb 2006

Eosinophilic esophagitis gene discovery

Researchers at Cincinnati Children's Hospital Medical Center have discovered the first gene associated with eosinophilic esophagitis, one of a number of eosinophil-related diseases in which the body produces abnormally large amounts of white blood cells that can lead to allergy related illnesses.

7 Feb 2006

Two-drug treatment could help asthma and chronic bronchitis sufferers

Current treatments for asthma and chronic bronchitis aren't able to address the ultimate source of the problem--they can only alleviate symptoms.

7 Feb 2006

Link between dementia and cancer

By expressing a protein associated with Alzheimer's disease in the brain of the fruit fly, researchers have demonstrated an intriguing link between neuronal death and proteins previously associated with cancer.

7 Feb 2006

Soy's cardiovascular benefits may have been overestimated

Many soy food products carry health claims stating that they reduce the risk of heart disease. A review of the evidence, however, suggests that soy's cardiovascular benefits may have been overestimated by the early studies that formed the basis for its health claim.

7 Feb 2006

Abraham Lincoln may have suffered from movement disorder

Researchers at Johns Hopkins and the University of Minnesota have discovered a gene mutation in the descendants of Abraham Lincoln's grandparents that suggests the Civil War president himself might have also suffered from a disease that destroys nerve cells in the cerebellum-- the part of the brain that controls movement.

7 Feb 2006

Myosin VI can act as molecular transporter

Myosin VI has been thought to be a monomer, but Park et al. show that full-length myosin VI can be a dimer, and can walk processively on actin. By increasing the concentration, a greater and greater fraction dimerizes in vitro, and walks processively on actin.

7 Feb 2006

Research sheds light on origins of "junk" DNA

In experiments with transgenic mice, University of Pennsylvania School of Medicine researchers discovered the remaining steps in the complicated process of how the largest class of jumping genes replicates and inserts themselves within the human genome.

7 Feb 2006

Source of crucial immune cell in the skin discovered - may lead to tumor immunotherapy

Mount Sinai School of Medicine researchers have identified the precursors of cells in the skin that are part of the first line of defense against invading pathogens. The study appears on Nature Immunology's website.

7 Feb 2006

Intracellular observation of RNA metabolism will help identify disease-associated RNAs

For the first time, researchers can now peer inside intact cells to not only identify RNA-binding proteins, but also observe-in real-time-the intricate activities of these special molecules that make them key players in managing some of the cell's most basic functions.

7 Feb 2006

Alternative method to produce heparin

Researchers at Rensselaer Polytechnic Institute and University of North Carolina at Chapel Hill have discovered an alternative way to produce heparin, a drug commonly used to stop or prevent blood from clotting.

7 Feb 2006

First description of female-specific Ischemia Syndrome

Although ischemic heart disease - the reduction of blood flow that can lead to heart attacks - is often considered a "man's disease," it takes the lives of more women than men each year. In fact, in 2000, about 60,000 more women than men died from cardiovascular disease.

5 Feb 2006

Link between high levels of a protein HtrA1 and preeclampsia

Mayo Clinic researchers have found an association between abnormally high levels of a protein named HtrA1 and preeclampsia, a sudden and dangerous rise in blood pressure that can result in premature delivery, disability or death for mother and fetus.

5 Feb 2006

Simple method to diagnose preeclampsia

Researchers at Yale School of Medicine have found that analyzing proteins in urine is a simple and objective method to diagnose and classify preeclampsia (PE), a complication of pregnancy causing high blood pressure after 20 weeks of gestation.

5 Feb 2006

Scientists have determined the detailed structure of an essential piece of the telomerase enzyme

Scientists have determined the detailed structure of an essential piece of the telomerase enzyme, an important contributor to the vast majority of human cancers. Understanding the physical shape of the protein has led to a better understanding of how it acts to immortalize cells - and should help scientists design broadly effective cancer drugs.

5 Feb 2006

Researchers show how estrogen turns genes on and off during cancer progression

Ohio - A new study suggests that the hormone estrogen works in partnership with other proteins to activate or suppress gene activity in breast cancer cells.

2 Feb 2006

60 new genes controlled by regulatory sequences

Researchers worldwide are seeking to define ancient sections of our genetic code that may soon be as important to medical science as genes.

2 Feb 2006

HMRI researcher lights a path to understanding brain diseases

Neurologist Mike Harrington of Pasadena, California's Huntington Medical Research Institutes argues that soon we may be able to detect brain disease before symptoms even begin. The secret is in the cerebrospinal fluid, the clear liquid that cushions our brain and spinal cord.

2 Feb 2006

Bird flu jab for chickens could halt spread of the virus

U.S. researchers say they have produced a vaccine in less than a month which completely protects chickens from the deadly H5N1 virus.

29 Jan 2006

New research has implications for treating muscular dystrophy

In a surprising discovery with implications for treating muscular dystrophy, researchers at the University of Utah School of Medicine and other institutions have identified a major source of origin for two groups of adult cells that regulate muscle repair.

27 Jan 2006