Laboratory News and Research

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Cumulative amount of specific gene products affects changes in cell fate, say researchers

Johns Hopkins biologists have discovered that when biological signals hit cells in rhythmic waves, the magnitude of the cells' response can depend on the number of signaling cycles — not their strength or duration. Because such so-called “oscillating signaling cycles” are common in many biological systems, the scientists expect their findings in single-celled organisms to help explain the molecular workings of phenomena such as tissue and organ formation and fundamental forms of learning.

24 Mar 2014

Drugs fail to "wake up" dormant reservoirs of HIV inside immune system T cells

Scientists at Johns Hopkins report that compounds they hoped would "wake up" dormant reservoirs of HIV inside immune system T cells - a strategy designed to reverse latency and make the cells vulnerable to destruction - have failed to do so in laboratory tests of such white blood cells taken directly from patients infected with HIV.

24 Mar 2014

New way to make large concentrations of skeletal muscle cells from human stem cells

As stem cells continue their gradual transition from the lab to the clinic, a research group at the University of Wisconsin-Madison has discovered a new way to make large concentrations of skeletal muscle cells and muscle progenitors from human stem cells.

24 Mar 2014

Scientists develop unique cells to repair patient's defective and diseased bladder

For the first time, scientists have succeeded in coaxing laboratory cultures of human stem cells to develop into the specialized, unique cells needed to repair a patient's defective or diseased bladder.

24 Mar 2014

Misplaced protein provides promising drug target for kidney cancer

The shortage of oxygen, or hypoxia, created when rapidly multiplying kidney cancer cells outgrow their local blood supply can accelerate tumor growth by causing a nuclear protein called SPOP-which normally suppresses tumor growth-to move out of the nucleus to the cytoplasm, where it has the opposite effect, promoting rapid proliferation.

21 Mar 2014

UC San Diego Library becomes official repository for the papers of Jonas Salk

The University of California, San Diego Library has become the official repository for the papers of Jonas Salk, noted physician, virologist, and humanitarian, best known for his development of the world's first successful vaccine for the prevention of polio.

21 Mar 2014

NIH awarded five-year grant of up to $28 million to fight deadly Ebola virus

The National Institutes of Health (NIH) has awarded a five-year grant of up to $28 million to establish a new center for excellence to find an antibody "cocktail" to fight the deadly Ebola virus.

21 Mar 2014

New tool pinpoints genetic sources of disease

Many diseases are the result of either variations in the genome or reversible chemical changes to DNA, known as the epigenome. New data obtained by Johns Hopkins scientists show a connection between genetic variants and epigenetic information.

20 Mar 2014

LSTM and University of Liverpool receive GHIT Fund to target lymphatic filariasis and onchocerciasis

The Liverpool School of Tropical Medicine (LSTM) together with colleagues at the Department of Chemistry (University of Liverpool (UoL)) and Japanese pharmaceutical company Eisai are pleased to announce that they have been awarded a Global Health Innovative Technology (GHIT) Fund to develop new drugs to target lymphatic filariasis and onchocerciasis.

20 Mar 2014

New mobile phone app could monitor diabetes, kidney disease and urinary tract infections

A recently-developed mobile phone application could make monitoring conditions such as diabetes, kidney disease, and urinary tract infections much clearer and easier for both patients and doctors, and could eventually be used to slow or limit the spread of pandemics in the developing world.

20 Mar 2014

Tamiflu cuts H1N1 pandemic deaths by 25%, shows study

Adults hospitalised with H1N1 influenza during the 2009–2010 pandemic were 25% less likely to die from the disease if they were given antiviral drugs called neuraminidase inhibitors (NAIs) such as Tamiflu, according to a large meta-analysis involving more than 29 000 patients from 38 countries, published in The Lancet Respiratory Medicine journal. The findings also indicate that treatment within 2 days of flu symptoms developing halved the risk of death compared with later treatment or no treatment.

20 Mar 2014

Stress undermines our relationships with other people

Stress, this enemy that haunts us every day, could be undermining not only our health but also our relationships with other people, especially if we are men. In fact, stressed women apparently become more "prosocial". These are the main findings of a study carried out with the collaboration of Giorgia Silani, from the International School for Advanced Studies of Trieste.

19 Mar 2014

BU wins $2.75M grant from NIDCD to test and refine prototype Visually Guided Hearing Aid

Boston University (BU) College of Health & Rehabilitation Sciences: Sargent College was recently awarded a five-year, $2.75M grant from the National Institute on Deafness and Other Communication Disorders (NIDCD) to test and refine a prototype Visually Guided Hearing Aid (VGHA).

19 Mar 2014

New improved mass spectrometry for analysis of chemical and biological materials

When it comes to analyzing cell components or body fluids or developing new medications, there is no way around mass spectrometry. Mass spectrometry is a highly sensitive method of measurement that has been used for many years for the analysis of chemical and biological materials.

19 Mar 2014

Engineers design modified lens to improve efficiency of lithotripsy

Duke engineers have devised a way to improve the efficiency of lithotripsy -- the demolition of kidney stones using focused shock waves. After decades of research, all it took was cutting a groove near the perimeter of the shock wave-focusing lens and changing its curvature.

19 Mar 2014

Cellectricon, UCL to host webinar to explore use of primary cells for biomedical research

Cellectricon, a leading provider of advanced cell-based screening technologies and services, will co-host a webinar with top researchers at University College London. The webinar will explore the use of primary cells as a biologically-relevant model for biomedical research, and highlight the new high-throughput techniques and phenotypic screening approaches that are used by UCL to investigate cellular processes in such cells.

From Cellectricon 19 Mar 2014

Lung cancer cells use novel mechanism to block detection by natural killer cell

The immune system plays a pivotal role in targeting cancer cells for destruction. However, tumor cells are smart and have developed ways to avoid immune detection.

19 Mar 2014

Quail and chickens are likely sources of infection of H7N9 influenza virus to humans

Among the copious species of poultry in China, quail and chickens are the likely sources of infection of H7N9 influenza virus to humans, according to a paper published ahead of print in the Journal of Virology.

19 Mar 2014

Nine fellows selected to receive Dennis Weatherstone Predoctoral Fellowship for next two years

Autism Speaks, the world's leading autism science and advocacy organization, today announced the sixth class of The Dennis Weatherstone Predoctoral Fellows funded by the Stavros Niarchos Foundation.

19 Mar 2014

Eye abnormalities may help reveal features of early-stage Alzheimer's disease, says study

Investigators at the Cedars-Sinai Regenerative Medicine Institute have discovered eye abnormalities that may help reveal features of early-stage Alzheimer's disease. Using a novel laboratory rat model of Alzheimer's disease and high-resolution imaging techniques, researchers correlated variations of the eye structure, to identify initial indicators of the disease.

18 Mar 2014

Laboratory News and Research

Cumulative amount of specific gene products affects changes in cell fate, say researchers

Drugs fail to "wake up" dormant reservoirs of HIV inside immune system T cells

New way to make large concentrations of skeletal muscle cells from human stem cells

Scientists develop unique cells to repair patient's defective and diseased bladder

Misplaced protein provides promising drug target for kidney cancer

UC San Diego Library becomes official repository for the papers of Jonas Salk

NIH awarded five-year grant of up to $28 million to fight deadly Ebola virus

New tool pinpoints genetic sources of disease

LSTM and University of Liverpool receive GHIT Fund to target lymphatic filariasis and onchocerciasis

New mobile phone app could monitor diabetes, kidney disease and urinary tract infections

Tamiflu cuts H1N1 pandemic deaths by 25%, shows study

Stress undermines our relationships with other people

BU wins $2.75M grant from NIDCD to test and refine prototype Visually Guided Hearing Aid

New improved mass spectrometry for analysis of chemical and biological materials

Engineers design modified lens to improve efficiency of lithotripsy

Cellectricon, UCL to host webinar to explore use of primary cells for biomedical research

Lung cancer cells use novel mechanism to block detection by natural killer cell

Quail and chickens are likely sources of infection of H7N9 influenza virus to humans

Nine fellows selected to receive Dennis Weatherstone Predoctoral Fellowship for next two years

Eye abnormalities may help reveal features of early-stage Alzheimer's disease, says study

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