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Hedgehog protein plays a role in regulating fat and bone

A protein that guides the early development of creatures as diverse as fruit flies and humans also plays a role in regulating fat and bone formation in adult organisms, researchers at UT Southwestern Medical Center have discovered.

10 Jan 2006

Gene that increases risk for Alzheimer's disease

An international team of researchers, led by investigators at Washington University School of Medicine in St. Louis, are zeroing in on a gene that increases risk for Alzheimer's disease. They have identified a region of chromosome 10 that appears to be involved in risk for the disease that currently affects an estimated 4.5 million Americans.

10 Jan 2006

Evidence for impaired retroviral defense genes in humans

Researchers Harmit Malik and Michael Emerman and colleagues at the Fred Hutchinson Cancer Research Center have found that a surprisingly large fraction of humans may be impaired in the function of a recently discovered arm of the body's defense against invading retroviruses such as HIV.

10 Jan 2006

Detecting MRSA outbreaks

German researchers have proposed an automated DNA sequence-based early warning system to detect methicillin-resistant Staphylococcus aureus (MRSA) outbreaks in hospitals, which they say could replace traditional slower techniques.

10 Jan 2006

Diet rich in veggies lowers blood pressure

Researchers say that a diet rich in vegetables rather than meat can help to reduce blood pressure, and the more plant protein consumed the better.

10 Jan 2006

Value of prostate tests dubious

According to new research, men screened for prostate cancer using blood tests or digital examinations die of the disease at much the same rate as those who were not checked.

10 Jan 2006

Study finds short-term lifestyle changes improve health even without major weight loss

Obese and overweight individuals suffering metabolic syndrome and Type 2 diabetes showed significant health improvements after only three weeks of diet and moderate exercise even though the participants remained overweight.

10 Jan 2006

Human Genome Sciences announces license agreement with Amgen

Human Genome Sciences has announced a license agreement with Amgen under which Amgen has acquired exclusive worldwide rights to develop and commercialize therapeutic biological products for human use based on a human gene discovered by Human Genome Sciences that may have potential applications in autoimmune diseases, immune deficiencies or suppression, and cancer.

10 Jan 2006

Polyphosphate speeds blood clotting and helps clots last longer

A serendipitous comparison prompted by an old scientific image and involving an ancient but understudied molecule may lead to a new treatment strategy for injuries or illnesses in which blood clotting is paramount to survival.

9 Jan 2006

The effectiveness of screening for prostate cancer

A screening test for prostate cancer that measures prostate-specific antigen (PSA) levels does not improve survival, researchers at the Veterans Affairs (VA) Connecticut Healthcare System and Yale School of Medicine report in the January 9 Archives of Internal Medicine.

9 Jan 2006

Genetic mutation that protects against HIV increases the risk of West Nile Virus infection

A genetic mutation that protects against HIV increases the risk of developing clinical West Nile Virus infection, according to a new study appearing online on January 9th in The Journal of Experimental Medicine.

9 Jan 2006

New research reveals a protein involved in lifting depression

Paul Greengard, Ph.D.,a Nobel Laureate researcher says that mice deficient in a protein, called p11, display depression-like behaviours, while those with sufficient amounts behave as if they have been treated with antidepressants.

9 Jan 2006

Myelin breakdown appears to be key contributor to Alzheimer disease later in life

A new UCLA imaging study shows that age-related breakdown of myelin, the fatty insulation coating the brain's internal wiring, correlates strongly with the presence of a key genetic risk factor for Alzheimer disease.

8 Jan 2006

Researchers uncover new toxic mechanism in ALS - Lou Gehrig's disease

Exactly how ALS - Lou Gehrig's disease - damages motor neurons is one of medical science's lingering mysteries. At least six mishaps within cells appear to contribute to the death of the nerves that enable muscle movement, but nothing stands out as the key problem.

6 Jan 2006

Evidence that the eye has complementary brain-signaling systems at work

A new retinal photoreceptor adjusts its sensitivity in different lighting conditions, according to scientists at Brown University, where the rare eye cells were discovered.

6 Jan 2006

DNA polymerase zeta gives cells with damaged DNA a new lease on life

Fortunately, our cells contain many enzymes devoted strictly to detecting and repairing any damage caused by these insults. In fact, failure of these enzymes to make needed repairs to genes can lead to the accumulation of mutations and, eventually, cell death or possibly cancer.

6 Jan 2006

Scientists describe phenomenon in the human genome called transcription-induced chimerism

In the January issue of the journal Genome Research, two teams of scientists describe a widespread phenomenon in the human genome called transcription-induced chimerism (TIC), where two adjacent genes produce a single, fused RNA transcript.

6 Jan 2006

Research indicates birth control pill could cause long-term problems with testosterone

In the January issue of The Journal of Sexual Medicine, researchers have published a new investigation measuring sex hormone binding globulin (SHBG) before and after discontinuation of the oral contraceptive pill.

6 Jan 2006

alphaB-crystallin may be a useful molecular marker to identify women with aggressive breast cancer

A groundbreaking study led by Northwestern University researchers has demonstrated that a protein called alphaB-crystallin, which normally protects cells from stress damage, triggers events that may cause breast cancer when overactive.

6 Jan 2006

Soy diet worsens heart disease in mice

Researchers from the University of Colorado have shown that mice carrying a genetic mutation that is linked to altered heart growth and function in humans, have significantly worse heart problems if fed a soy diet, when compared to mice fed a soy-free (milk protein-based) diet.

6 Jan 2006