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Proteasome inhibitor treatment can lead to cardiovascular problems in multiple myeloma patients

The proteasome inhibitor carfilzomib has taken on an increasing role in the treatment of multiple myeloma, but new research from the Abramson Cancer Center of the University of Pennsylvania shows the therapy comes with the risk of cardiovascular problems in a higher than expected percentage of patients.

28 Dec 2017

UAB study shows missense mutations as key risk factor for severe symptoms of neurofibromatosis type 1

Research led by Ludwine Messiaen, Ph.D., professor of genetics at the University of Alabama at Birmingham, shows that missense mutations in a cluster of just five codons in the NF1 gene are an important risk factor for severe symptoms of the genetic disease neurofibromatosis type 1.

28 Dec 2017

UCLA study reveals positive effects of estrogen treatment in people with MS

A study by UCLA researchers reveals the cellular basis for how the hormone estrogen protects against damage to the central nervous system in people with multiple sclerosis (MS).

28 Dec 2017

Researchers reveal how tumor cells disrupt circadian rhythm to survive

Tumor cells use the unfolded protein response to alter circadian rhythm, which contributes to more tumor growth, Hollings Cancer Center researchers at the Medical University of South Carolina find.

28 Dec 2017

$Study uncovers genomic targets in refractory neuroblastoma$

Study uncovers genomic targets in refractory neuroblastoma

Neuroblastoma (NB) is the most common solid tumor found in children. It starts in some very early forms of nerve cells found in the embryo or fetus.

28 Dec 2017

Research provides new understanding of how cancer cells move during metastasis

A University of Hawai'i Cancer Center researcher has identified how some cancer cells are made to move during metastasis. The research provides a better understanding of how cancer spreads and may create new opportunities for cancer drug development.

28 Dec 2017

Reduced activity of transcription factor plays key role in triggering pulmonary fibrosis

To date, the molecular basis of pulmonary fibrosis has been poorly understood. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now shown that reduced activity of the transcription factor FoxO3 plays a key role in the development of the disease.

26 Dec 2017

Scientists provide detailed insight into molecular mechanisms of ALS

Scientists have revealed more details of the molecular mechanism behind neuronal cell death in amyotrophic lateral sclerosis (ALS), a step forward to find ways to control progression of the disease.

26 Dec 2017

Researchers find progenitor cells for all the heart's components, except right ventricle

Progenitor cells - undifferentiated cells that later become specified - for all the heart's components, except for the right ventricle, have been found by Hiroshima University researchers and detailed in a paper published in Nature Communications.

26 Dec 2017

Study finds role of ligands in allergic sensitization phase

Researchers from Universidad Politécnica de Madrid find direct evidence that the ligands, compounds carried by allergens, are actively involved in the allergic sensitization phase.

26 Dec 2017

International researchers find valuable clues for developing robust therapeutic agents against IBDs

Our immune system protects our bodies from numerous pathogenic microbes and toxins in the environment. The system comprises innate (non-specific) and adaptive (acquired) immunity.

26 Dec 2017

New method sifts through millions of molecular targets to find precise tumor beacon

By screening millions of molecular targets, researchers have uncovered a tumor beacon detected by the immune cells of two patients with colorectal cancer.

22 Dec 2017

Scientists elucidate why exercise slows progression of Parkinson's disease

While vigorous exercise on a treadmill has been shown to slow the progression of Parkinson's disease in patients, the molecular reasons behind it have remained a mystery.

22 Dec 2017

Study identifies biomarker targets to make existing drugs better at combating cancer

A new study published in Nature Communications and led by University of Kentucky Markey Cancer Center researcher Qing-Bai She identifies biomarker targets that may make existing drugs more effective in fighting certain cancers.

22 Dec 2017

UW study finds how tightly bound protein complexes are broken apart to become inactivated

A new study by University of Wisconsin-Madison researchers identified the structural basis for how tightly bound protein complexes are broken apart to become inactivated.

22 Dec 2017

Study suggests new target to treat prostate cancer

Hokkaido University researchers have uncovered a cellular protein that stabilizes a tumor promoting signaling pathway, suggesting a new target to treat prostate cancer.

22 Dec 2017

Salk scientists find simpler way to derive functioning cardiac cells from stem cells

The process by which embryonic stem cells develop into heart cells is a complex process involving the precisely timed activation of several molecular pathways and at least 200 genes.

22 Dec 2017

Ability to defend against environmental stress may affect longevity

A shorter life may be the price an organism pays for coping with the natural assaults of daily living, according to researchers at the National Institutes of Health and their colleagues in Japan.

21 Dec 2017

Multifunctional protein also plays role in development of blood cells

Like an actor who excels at both comedy and drama, proteins also can play multiple roles. Uncovering these varied talents can teach researchers more about the inner workings of cells.

21 Dec 2017

Scientists unravel structure of protein behind sense of touch

Scientists at The Scripps Research Institute have solved the mystery of the structure of Piezo1, a member of a family of proteins that convert physical stimuli such as touch or blood flow into chemical signals.

21 Dec 2017

Protein C News and Research

Proteasome inhibitor treatment can lead to cardiovascular problems in multiple myeloma patients

UAB study shows missense mutations as key risk factor for severe symptoms of neurofibromatosis type 1

UCLA study reveals positive effects of estrogen treatment in people with MS

Researchers reveal how tumor cells disrupt circadian rhythm to survive

Study uncovers genomic targets in refractory neuroblastoma

Research provides new understanding of how cancer cells move during metastasis

Reduced activity of transcription factor plays key role in triggering pulmonary fibrosis

Scientists provide detailed insight into molecular mechanisms of ALS

Researchers find progenitor cells for all the heart's components, except right ventricle

Study finds role of ligands in allergic sensitization phase

International researchers find valuable clues for developing robust therapeutic agents against IBDs

New method sifts through millions of molecular targets to find precise tumor beacon

Scientists elucidate why exercise slows progression of Parkinson's disease

Study identifies biomarker targets to make existing drugs better at combating cancer

UW study finds how tightly bound protein complexes are broken apart to become inactivated

Study suggests new target to treat prostate cancer

Salk scientists find simpler way to derive functioning cardiac cells from stem cells

Ability to defend against environmental stress may affect longevity

Multifunctional protein also plays role in development of blood cells

Scientists unravel structure of protein behind sense of touch

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