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C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance

New research shows that levels of C-reactive protein (CRP), produced by the liver and not at the lesion site, correlate with the degree of atherosclerosis.

28 Sep 2005

Dengue and other viruses may have developed tricks that let them reproduce inside macrophages

A monoclonal antibody that can effectively treat mice infected with West Nile virus has an intriguing secret: Contrary to scientists' expectations, it does not block the virus's ability to attach to host cells. Instead, the antibody somehow stops the infectious process at a later point.

28 Sep 2005

Discovery may lead to development of more effective antibiotics

Researchers at the Georgia Institute of Technology and the John Innes Centre in the United Kingdom have uncovered a mechanism with which disease-causing bacteria may thwart the body's natural defense responses. The findings, which could ultimately lead to the development of more effective antibiotics, appear in the September 29, 2005 issue of the journal Nature.

28 Sep 2005

New Stat1 and interferon findings

By altering a molecule called Stat1, which is involved in cellular immune signaling, scientists have succeeded in making the molecule more responsive and thus more efficient. This old protein with a new twist may eventually be used to improve the body's defense against infection.

28 Sep 2005

Discovered of gene mutations associated with hereditary neuralgic amyotrophy

In a significant advance toward understanding a perplexing and painful neurological disorder, an international team of researchers has discovered gene mutations associated with an inherited chronic pain and weakness syndrome known as hereditary neuralgic amyotrophy (also called HNA).

27 Sep 2005

Possibility of tailored treatments for addiction based on how a person's genes behave

Scientists have learned how a genetic variation long suspected in making some people susceptible to alcoholism and narcotic drug addiction actually does so.

27 Sep 2005

Pursuit of potential drugs and small molecules that target the IGF-1 receptor

Pharmaceutical companies around the world still come knocking on Renato Baserga, M.D.,'s door. And for good reason.

27 Sep 2005

Cancer vaccine based on the bacterium Listeria monocytogenes, can cure mice with breast tumors

A team from the University of Pennsylvania School of Medicine has shown that by using a cancer vaccine based on the bacterium Listeria monocytogenes, they can cure mice with established breast tumors. Cancer vaccines, which are more properly described as immunotherapy, work by boosting an immune response against tumor-associated antigens.

27 Sep 2005

Farnesyl transferase inhibitors may help chidren with Hutchinson-Gilford progeria syndrome

Johns Hopkins scientists have discovered that a drug currently being tested against cancers might help children with a rare, fatal condition called Hutchinson-Gilford progeria syndrome, which causes rapid, premature aging.

27 Sep 2005

Computer program helps explain how the same proteins can play different roles in a wide range of cellular processes

University of California, San Diego biochemists have developed a computer program that helps explain a long-standing mystery: how the same proteins can play different roles in a wide range of cellular processes, including those leading to immune responses and cancer.

27 Sep 2005

Gene responsible for Neuralgic Amyotrophy identified

Neuralgic Amyotrophy is a painful disorder of the peripheral nervous system. This heritable disease causes prolonged acute attacks of pain in the shoulder or arm, followed by temporary paralysis.

27 Sep 2005

Pulsing heart cell provides clues into how heart disease develops

A pulsing heart cell is giving Oregon Health & Science University researchers insight into how it sends and receives signals, and that's providing clues into how heart disease and other disorders develop.

27 Sep 2005

Researchers at Johns Hopkins have identified three new genetic mutations in brain tumors

...a discovery that could pave the way for more effective cancer treatments.

27 Sep 2005

Discovery of molecule that causes transverse myelitis

Hopkins researchers have discovered a single molecule that is a cause of an autoimmune disease in the central nervous system, called transverse myelitis (TM), that is related to multiple sclerosis.

26 Sep 2005

Antibody in humans that quickly fights the smallpox virus

Researchers at the La Jolla Institute for Allergy & Immunology (LIAI) have made a major advancement toward protecting society against a smallpox outbreak by identifying an antibody in humans that quickly fights the smallpox virus.

26 Sep 2005

Deep-sea sponges harbor toxins that potentially can act as powerful anti-cancer drugs

Vibrantly colored creatures from the depths of the South Pacific Ocean harbor toxins that potentially can act as powerful anti-cancer drugs, according to research findings from University of Wisconsin-Madison biochemists and their Italian colleagues.

26 Sep 2005

Increlex - first major innovation in 20 years for the treatment of growth failure

Rush University Medical Center is participating in a clinical trial to evaluate the potential benefit of the first major innovation in 20 years for the treatment of growth failure.

26 Sep 2005

Tumor formation is generated by a complex interaction of both mechanical as well as chemical signals

The relationship between tissue rigidity and tumor formation is fairly well established; however, what is not so well understood is what happens on a molecular level that contributes to such stiffness.

26 Sep 2005

First step towards effective drug-addiction therapies

A novel chemical compound that blocks memory-related drug cravings has the potential to be the basis of new therapies to aid drug-addiction recovery efforts, UC Irvine neurobiologists have found.

26 Sep 2005

Chronically high levels of insulin may block specific hormones that trigger energy release into the body

Their findings, which may point to new approaches to developing improved treatment options for the disease, are published in the journal Nature.

26 Sep 2005

G Protein News and Research

C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance

Dengue and other viruses may have developed tricks that let them reproduce inside macrophages

Discovery may lead to development of more effective antibiotics

New Stat1 and interferon findings

Discovered of gene mutations associated with hereditary neuralgic amyotrophy

Possibility of tailored treatments for addiction based on how a person's genes behave

Pursuit of potential drugs and small molecules that target the IGF-1 receptor

Cancer vaccine based on the bacterium Listeria monocytogenes, can cure mice with breast tumors

Farnesyl transferase inhibitors may help chidren with Hutchinson-Gilford progeria syndrome

Computer program helps explain how the same proteins can play different roles in a wide range of cellular processes

Gene responsible for Neuralgic Amyotrophy identified

Pulsing heart cell provides clues into how heart disease develops

Researchers at Johns Hopkins have identified three new genetic mutations in brain tumors

Discovery of molecule that causes transverse myelitis

Antibody in humans that quickly fights the smallpox virus

Deep-sea sponges harbor toxins that potentially can act as powerful anti-cancer drugs

Increlex - first major innovation in 20 years for the treatment of growth failure

Tumor formation is generated by a complex interaction of both mechanical as well as chemical signals

First step towards effective drug-addiction therapies

Chronically high levels of insulin may block specific hormones that trigger energy release into the body

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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