Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Study shows potential of avelumab plus axitinib as new treatment option for patients with advanced RCC

A combination of the immune checkpoint blocker, avelumab, plus the tyrosine kinase inhibitor, axitinib, significantly improves progression-free survival in previously untreated patients with advanced renal cell carcinoma in a phase 3 study, according to results presented at ESMO 2018 Congress.

22 Oct 2018

LYNPARZA Phase III SOLO-1 results show improved outcome for patients with advanced BRCA-mutated ovarian cancer

AstraZeneca and Merck & Co., Inc., Kenilworth, N.J., today announced detailed results from the Phase III SOLO-1 trial testing LYNPARZA (olaparib) 300 mg tablets twice-daily as a maintenance treatment for patients with newly diagnosed advanced BRCA-mutated ovarian cancer who were in complete or partial response following 1st-line standard platinum-based chemotherapy.

22 Oct 2018

Vertex gets European CHMP positive opinion for KALYDECO to treat patients with cystic fibrosis

Vertex Pharmaceuticals (Europe) Limited today announces that the European Medicines Agency's Committee for Medicinal Products for Human Use adopted a positive opinion for KALYDECO (ivacaftor) to include the treatment of people with cystic fibrosis (CF) aged 12 to <24 months who have at least one of the following nine mutations in their cystic fibrosis transmembrane conductance regulator gene: G551D, G1244E, G1349D, G178R, G551S, S1251N, S1255P, S549N or S549R.

22 Oct 2018

Immunotherapy increases survival in some patients with metastatic triple negative breast cancer

Immunotherapy improves survival in some patients with metastatic triple negative breast cancer, according to late-breaking results from the IMpassion130 trial reported at the ESMO 2018 Congress in Munich.

22 Oct 2018

Exelixis presents CABOSUN and METEOR trial results in patients with advanced renal cell carcinoma

Exelixis, Inc. today announced results from two analyses evaluating the effect of PD-L1 expression or prior treatment with immune checkpoint inhibitors on the efficacy of cabozantinib in patients with advanced renal cell carcinoma (RCC). The findings are being presented this week at the European Society for Medical Oncology 2018 Congress being held October 19-23 in Munich, Germany.

22 Oct 2018

Research provides insight into neurobiology of aggression and bullying

Duke-NUS researchers have discovered that a growth factor protein, called brain-derived neurotrophic factor, and its receptor, tropomyosin receptor kinase B affects social dominance in mice. The research has implications for understanding the neurobiology of aggression and bullying.

20 Oct 2018

ApoE4 gene linked with chronic inflammation increases risk for Alzheimer's disease

While it is widely shown that possessing the ApoE4 gene is the major genetic risk factor of Alzheimer's disease, not all ApoE4 carriers develop AD.

20 Oct 2018

Study reveals connection between two proteins known to be hyperactive in cancer

A team of researchers at Baylor College of Medicine and Texas Children's Hospital has revealed a connection between mTORC1 and Src, two proteins known to be hyperactive in cancer.

20 Oct 2018

Scientists uncover key regulator of mTORC1 in cancer growth

Scientists have discovered that Src is needed for activation of mTORC1, a major regulator of cellular metabolism, growth and proliferation in cancer.

19 Oct 2018

Breast Cancer as a Dynamic Disease

An interview with Dr. Andrew Ewald, discussing the influence of the myoepithelium on breast cancer growth and the importance of studying metastasis.

19 Oct 2018

Prion strain diversity may be greater than previously thought

The first example of prion strains that replicate independently in vitro and in vivo suggests that strain diversity may be greater than previously thought, according to a study published October 18 in the open-access journal PLOS Pathogens by Jason Bartz of Creighton University, and colleagues.

19 Oct 2018

Newly discovered toxin stands out from others in the battle for microbial domination

A newly discovered toxin that some bacteria deploy to fend off competing bacteria stands out from others in the battle for microbial domination. While many deadly substances have been identified among bacteria, this previously unknown toxin behaves in a familiar way.

19 Oct 2018

Understanding of metal-free enzymes used by bacteria could lead to new effective antibiotics

Some bacterial pathogens, including those that cause strep throat and pneumonia, are able to create the components necessary to replicate their DNA without the usually required metal ions.

19 Oct 2018

UT Southwestern biochemist receives 2019 Breakthrough Prize in Life Sciences for innate immunity discovery

UT Southwestern biochemist Dr. Zhijian "James" Chen today was named winner of the prestigious 2019 Breakthrough Prize in Life Sciences for his discovery of the cGAS enzyme that launches the body's immune defense against infections and cancers.

19 Oct 2018

Muscle mass plays a critical role in health, shows research

Adults go to the doctor roughly three times a year. During their visit, vitals are taken such as blood pressure, pulse, and weight, but are these measurements really showing the full picture of a person's overall health?

19 Oct 2018

Gene sequencing reveals crucial molecular aspects of Trypanosoma brucei

Trypanosoma brucei, which causes sleeping sickness, evades the immune system by repeatedly altering the structure of its surface coat. Sequencing of its genome and studies of its 3D genome architecture have now revealed crucial molecular aspects of this strategy.

19 Oct 2018

Next-generation RNA sequencing technology sheds new light on human mitochondrial diseases

The ability to translate the genetic code into proteins is an essential step in all living organisms. A cornerstone of this molecular process is the ability of transfer RNA (tRNA) molecules to couple recognition of the genetic code with the cognate amino acid, which are the building blocks of proteins.

19 Oct 2018

People with more copies of AMY1 gene digest starchy carbohydrates faster

Found in saliva, the protein enzyme encoded by the AMY1 gene begins the digestive process by breaking down starch when you chew your food.

19 Oct 2018

Healthy candies for diabetic patients

The technology of making sweets has been worked out for more than months, experiments have led to the invention of exclusive flavors, which are not yet available on the confectionery market.

19 Oct 2018

Midazolam-mediated alterations of PER2 expression may have functional consequences during myocardial ischemia

Innovative cardioprotective strategies are of imminent demand. Nonfatal myocardial ischemia (MI) poses a significant risk to patients undergoing major non-cardiac surgery and these non-cardiac surgeries account for around 8 million myocardial injuries per year

19 Oct 2018

Protein News and Research

Further Reading

Study shows potential of avelumab plus axitinib as new treatment option for patients with advanced RCC

LYNPARZA Phase III SOLO-1 results show improved outcome for patients with advanced BRCA-mutated ovarian cancer

Vertex gets European CHMP positive opinion for KALYDECO to treat patients with cystic fibrosis

Immunotherapy increases survival in some patients with metastatic triple negative breast cancer

Exelixis presents CABOSUN and METEOR trial results in patients with advanced renal cell carcinoma

Research provides insight into neurobiology of aggression and bullying

ApoE4 gene linked with chronic inflammation increases risk for Alzheimer's disease

Study reveals connection between two proteins known to be hyperactive in cancer

Scientists uncover key regulator of mTORC1 in cancer growth

Breast Cancer as a Dynamic Disease

Prion strain diversity may be greater than previously thought

Newly discovered toxin stands out from others in the battle for microbial domination

Understanding of metal-free enzymes used by bacteria could lead to new effective antibiotics

UT Southwestern biochemist receives 2019 Breakthrough Prize in Life Sciences for innate immunity discovery

Muscle mass plays a critical role in health, shows research

Gene sequencing reveals crucial molecular aspects of Trypanosoma brucei

Next-generation RNA sequencing technology sheds new light on human mitochondrial diseases

People with more copies of AMY1 gene digest starchy carbohydrates faster

Healthy candies for diabetic patients

Midazolam-mediated alterations of PER2 expression may have functional consequences during myocardial ischemia

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