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Researchers test experimental drug Neuprex on infants undergoing heart surgery

UT Southwestern Medical Center is the only institution in the nation approved by the Food and Drug Administration to test an experimental drug on infants undergoing heart surgery to see whether it can help them avoid potentially lethal infections and improve survival.

22 Aug 2005

First proof of how the rare disorder Fanconi anemia causes chromosomal instability

The scientists found a gene mutation not previously known to be related to Fanconi anemia, and they say that BRIP1 is the first gene associated with the disease whose protein has a known function.

22 Aug 2005

Novel vaccine strain with high efficacy against tuberculosis

Tuberculosis remains a major global health threat. Although more than 3 billion doses of the BCG vaccine have been administered to fight tuberculosis, the ability of the BCG vaccine to protect adults is very limited, as is its efficacy against newly emerging isolates.

22 Aug 2005

New method to predict protein separation behavior directly from protein structure

Applying math and computers to the drug-discovery process, researchers at Rensselaer Polytechnic Institute have developed a method to predict protein separation behavior directly from protein structure.

22 Aug 2005

Discovery of new gene FANCM sheds light on repair of damaged DNA

National Institute on Aging (NIA) researchers have discovered a new gene, FANCM, which sheds light on an important pathway involved in the repair of damaged DNA.

22 Aug 2005

Cancer Research Technology licenses novel cancer diagnostic markers

Cancer Research Technology Limited announced today that they have entered into a worldwide license agreement with TriPath Imaging, Inc.

22 Aug 2005

SH2-B enhances brain's leptin sensitivity - may lead to clues for treatment of obesity and diabetes

What do laboratory mice at the University of Michigan Medical School have in common with millions of overweight Americans? Like many of us, these mice just can't stop eating.

18 Aug 2005

Protein Sirt1 points to new therapies for type 2 diabetes

Opening the possibility of new therapies for type 2 diabetes, researchers at Washington University School of Medicine in St. Louis have found that a protein called Sirt1 enhances the secretion of insulin in mice and allows them to better control blood glucose levels. Their study appears in the August 17 issue of Cell Metabolism.

18 Aug 2005

Mutations in the targets of designer drugs critically influence their effectiveness

Two designer cancer drugs differed dramatically in a laboratory test comparing their ability to shut down a mutant, overactive growth signal in lung cancer cells, reports a team headed by scientists at the Dana-Farber Cancer Institute.

18 Aug 2005

Defects in newly discovered pathway may be an overlooked cause of anemia

Researchers studying zebrafish that die from anemia have discovered a new pathway for the synthesis of heme, the deep red, iron-containing molecule that is a component of hemoglobin and myoglobin.

18 Aug 2005

C. elegans has similar virus-fighting mechanism as humans and can be used in research

Researchers at the University of California, Riverside have discovered that a simple worm, called C. elegans, makes an excellent experimental host for studying some of the most virulent viruses that infect humans.

17 Aug 2005

Loss of a gene called p63 accelerates aging in mice

Researchers have discovered that the loss of a gene called p63 accelerates aging in mice. Similar versions of the gene are present in many organisms, including humans. Therefore, the p63 gene is likely to play a fundamental biological role in aging-related processes.

17 Aug 2005

Biochemical switch that affects how neurons fire in a part of the brain associated with learning

Researchers at UT Southwestern Medical Center have identified a biochemical switch that affects how neurons fire in a part of the brain associated with learning, findings that may aid in understanding schizophrenia and Alzheimer's disease.

17 Aug 2005

Low hemoglobin levels are a predictor of increased risk of death among heart failure patients

Hemoglobin (Hgb) is the major substance in red blood cells, and its level indicates the blood's ability to carry oxygen throughout the body. Studies have shown that low hemoglobin, which may result in anemia, is more common among patients with heart failure than it is among people in the general population.

17 Aug 2005

Interferon selectively kills colon cancer cells when combined with irinotecan chemotherapy agent

Johns Hopkins Kimmel Cancer Center scientists have found that interferon, used for 30 years to treat blood cancers, multiple sclerosis and hepatitis, selectively kills colon cancer cells when combined with another standard chemotherapy agent.

16 Aug 2005

Gene expression levels may reveal stage of Huntington's disease

A survey of the genome of patients with Huntington's Disease (HD) has identified potential markers of the progression of this devastating neurological disorder.

16 Aug 2005

Weight control protein may yield new approaches for treating obesity and type 2 diabetes

The findings in mice further suggest that particular variants of the protein SH2-B might underlie obesity in humans, the researchers said.

16 Aug 2005

Enzyme called matriptase, when left to its own devices, can cause cance

Scientists at the National Institute of Dental and Craniofacial Research (NIDCR) and colleagues report in animal studies that a single, scissor-like enzyme called matriptase, when left to its own devices, can cause cancer.

16 Aug 2005

New hope for those deaf from immune system attack

A new study may one day help those deafened by immune system attack, and possibly also lead to a test that could show which patients may be helped by immediate steroid treatment.

16 Aug 2005

Gene therapy success for the treatment of congenital muscular dystrophy (CMD) in mice

Researchers from the University of Pittsburgh report the first study to achieve success with gene therapy for the treatment of congenital muscular dystrophy (CMD) in mice, demonstrating that the formidable scientific challenges that have cast doubt on gene therapy ever being feasible for children with muscular dystrophy can be overcome.

15 Aug 2005

G Protein News and Research

Researchers test experimental drug Neuprex on infants undergoing heart surgery

First proof of how the rare disorder Fanconi anemia causes chromosomal instability

Novel vaccine strain with high efficacy against tuberculosis

New method to predict protein separation behavior directly from protein structure

Discovery of new gene FANCM sheds light on repair of damaged DNA

Cancer Research Technology licenses novel cancer diagnostic markers

SH2-B enhances brain's leptin sensitivity - may lead to clues for treatment of obesity and diabetes

Protein Sirt1 points to new therapies for type 2 diabetes

Mutations in the targets of designer drugs critically influence their effectiveness

Defects in newly discovered pathway may be an overlooked cause of anemia

C. elegans has similar virus-fighting mechanism as humans and can be used in research

Loss of a gene called p63 accelerates aging in mice

Biochemical switch that affects how neurons fire in a part of the brain associated with learning

Low hemoglobin levels are a predictor of increased risk of death among heart failure patients

Interferon selectively kills colon cancer cells when combined with irinotecan chemotherapy agent

Gene expression levels may reveal stage of Huntington's disease

Weight control protein may yield new approaches for treating obesity and type 2 diabetes

Enzyme called matriptase, when left to its own devices, can cause cance

New hope for those deaf from immune system attack

Gene therapy success for the treatment of congenital muscular dystrophy (CMD) in mice

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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