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Effect of COVID-19 mRNA vaccine on in vitro glial cells of the brain studied by Raman spectroscopy and imaging

Researchers studied how the mRNA-based BNT162b2 COVID-19 vaccine altered the biochemical composition of glial and glioma brain cells in vitro.

8 Mar 2022

The NFL has been using an unproven measure to get players with covid back on the field fast

Two months before the Super Bowl, the omicron surge was decimating NFL rosters as players tested positive for covid-19. In mid-December, the NFL postponed a game between the Los Angeles Rams and the Seattle Seahawks because the Rams, who would go on to win the Super Bowl, had 29 players out with covid.

8 Mar 2022

Roche Diagnostics introduces new molecular laboratory instrument in the UK

Roche Diagnostics has launched its new molecular laboratory instrument, the cobas® 5800 System, in the UK. Through improved automation the new system can help raise testing volumes, improve operational efficiency and manage the increasing demand that many laboratories are experiencing.

From Roche Sequencing and Life Science 8 Mar 2022

Development of RT-qPCR assays for differentiating SARS-CoV-2 Omicron BA.1 and BA.2 variants

In a recent study posted to the medRxiv*preprint server, a team of researchers from Israel developed and validated novel reverse transcriptase - quantitative polymerase chain reaction (RT-qPCR) assays. The new assays enable the rapid and high throughput identification and differentiation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.1 and BA.2 variants.

8 Mar 2022

Study identifies new ways to enhance SC-beta cell survivability through genetic manipulation

Recent advances in the transplantation of stem cell-derived insulin-producing beta cells (SC-beta cells) to treat type 1 diabetes (T1D) has generated considerable interest and excitement.

3 Mar 2022

Angiotensin-converting enzyme 2-based mutant decoy effectively reduces COVID-19 in mice

Researchers engineered a mutant ACE2 decoy that effectively protected human lung epithelia from SARS-CoV-2 infection by competitively binding to its spike protein.

3 Mar 2022

Study provides insight into what causes therapy failure in patients with myelodysplastic syndromes

Researchers from The University of Texas MD Anderson Cancer Center discovered that treatment resistance in patients with myelodysplastic syndromes (MDS) is caused by two distinct classes of stem cells and identified possible therapeutic approaches that target these cells.

3 Mar 2022

Study establishes that a low dose SARS-CoV-2 infection increases risk of pneumococcal coinfection

A new study published on the bioRxiv* preprint server has evaluated bacterial susceptibility during SARS-CoV-2 infection.

3 Mar 2022

Scientists find no connection between pandemic chilblains and SARS-CoV-2 infection

A recent study provides a better understanding of whether SARS-CoV-2 infection is linked with the occurrence of chilblains.

3 Mar 2022

Dual therapeutic potential of zapnometinib against COVID-19

Researchers assessed the impact of the drug zapnometinib on human immune response against coronavirus disease 2019.

2 Mar 2022

Phase 2/3 study of oral RHB-107 in non-hospitalized COVID-19 patients shows promising results

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced positive top-line results from the Phase 2 part of the Phase 2/3 study of once-daily oral RHB-107 (upamostat) in non-hospitalized symptomatic COVID-19 patients, predominantly conducted in the U.S. (60/61 patients) as well as South Africa.

1 Mar 2022

Research sheds light on the role of lipids in Alzheimer’s disease development

Neurons in the brain coexist with and rely on many other cell types to function properly. Astrocytes, which take their name from their star shape, ensure the survival of neurons by feeding and detoxifying them with the help of a multifunctional protein, APOE.

1 Mar 2022

Biophysical fitness profile of SARS-CoV-2 Delta variant

In a recent study posted to the bioRxiv* preprint server, researchers investigated the biophysical fitness landscape of the receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant.

1 Mar 2022

Encouraging in vitro results with SARS-CoV-2-spike-specific polyclonal antibody fragments

In a recent study posted to the bioRxiv* preprint server, researchers demonstrated the potent neutralizing ability of a polyclonal equine antibody (Ab), FBR-002, against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs), including Omicron.

28 Feb 2022

Mechanisms leading to Parkinson's disease following SARS-CoV-2 infection

In a recent study posted to the bioRxiv* preprint server, researchers demonstrated the impact of an amyloidogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein fragment named SFYVYSRVK (SK9) on the α-synuclein (aS) monomers and fibrils, a potential risk factor for Parkinson's disease.

28 Feb 2022

A study on the evolution of avian coronavirus escape mutants in vitro

A recent study included an in vitro assessment of the effect of antibody titers and vaccine combinations on the emergence of escape mutants of AvCoV.

28 Feb 2022

Scientists investigate the antiviral properties of cow milk protein against SARS-CoV-2 variants

As the COVID-19 pandemic continues to claim lives around the world, dairy scientists may have a surprising role to play. In a new report published in the Journal of Dairy Science, scientists from the University of Michigan (Ann Arbor, MI, USA) and Glanbia PLC Research and Development (Twin Falls, ID, USA) have collaborated to investigate the antiviral properties of cow milk protein against variants of SARS-CoV-2, the virus behind the illness.

28 Feb 2022

Studying coagulopathy in COVID-19

A new study published in the journal Diagnostics provided an overview of ROTEM with a particular focus on interpreting the symmetrical clot formation curve. Researchers also introduced new parameters that could aid in distinguishing between COVID-19 patients and outcomes.

28 Feb 2022

Noncovalent protease inhibitors against SARS-CoV-2 and other coronaviruses

In a new study published in ACS Infectious Diseases journal, scientists biochemically and structurally evaluated the PLpro from a subgroup 2b bat coronavirus, BtSCoV-Rf1.2004, to identify unique structural features or enzymatic biases of the subgroup 2b.

28 Feb 2022

Harvard’s new kidney engineering technology licensed to San Diego-based Trestle Biotherapeutics

A newly launched startup is building upon innovations developed over several years at the Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard John A. Paulson School of Engineering & Applied Sciences (SEAS), and Brigham and Women’s Hospital (Brigham) to engineer functional kidney tissue for renal repair and replacement therapy.

25 Feb 2022

in vitro News and Research

Effect of COVID-19 mRNA vaccine on in vitro glial cells of the brain studied by Raman spectroscopy and imaging

The NFL has been using an unproven measure to get players with covid back on the field fast

Roche Diagnostics introduces new molecular laboratory instrument in the UK

Development of RT-qPCR assays for differentiating SARS-CoV-2 Omicron BA.1 and BA.2 variants

Study identifies new ways to enhance SC-beta cell survivability through genetic manipulation

Angiotensin-converting enzyme 2-based mutant decoy effectively reduces COVID-19 in mice

Study provides insight into what causes therapy failure in patients with myelodysplastic syndromes

Study establishes that a low dose SARS-CoV-2 infection increases risk of pneumococcal coinfection

Scientists find no connection between pandemic chilblains and SARS-CoV-2 infection

Dual therapeutic potential of zapnometinib against COVID-19

Phase 2/3 study of oral RHB-107 in non-hospitalized COVID-19 patients shows promising results

Research sheds light on the role of lipids in Alzheimer’s disease development

Biophysical fitness profile of SARS-CoV-2 Delta variant

Encouraging in vitro results with SARS-CoV-2-spike-specific polyclonal antibody fragments

Mechanisms leading to Parkinson's disease following SARS-CoV-2 infection

A study on the evolution of avian coronavirus escape mutants in vitro

Scientists investigate the antiviral properties of cow milk protein against SARS-CoV-2 variants

Studying coagulopathy in COVID-19

Noncovalent protease inhibitors against SARS-CoV-2 and other coronaviruses

Harvard’s new kidney engineering technology licensed to San Diego-based Trestle Biotherapeutics

Driving innovation in drug discovery with in vitro biology solutions eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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