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DLX5 gene may play a role in the pathology of Rett Syndrome

A research team led by Terumi Kohwi-Shigematsu of the Life Sciences Division of Lawrence Berkeley National Laboratory has identified a gene, DLX5, that may play a role in the pathology of Rett Syndrome, a devastating neurological disorder diagnosed almost exclusively in girls.

20 Dec 2004

Tentative approval for Topiramate Tablets

Ranbaxy Pharmaceuticals announced tentative approval from the U.S. Food and Drug Administration to manufacture and market Topiramate Tablets, 25 mg, 100 mg, and 200 mg. Total annual market sales for Topiramate were $1,184 million with sales of these three strengths of tablets totaling $1,129 million.

20 Dec 2004

Rett Syndrome, the first identified epigenetic disease - linked to specific defects in the three-dimensional folding of chromatin

Sometime between the age of 6 and 18 months, after a period of seemingly normal development, girls affected with Rett Syndrome lose interest in play; they gradually become withdrawn and anxious, develop autistic-like behaviors, and acquire specific symptoms like repetitive teeth-grinding and hand-wringing.

20 Dec 2004

The regulation of physical activity in young children

The evidence at present suggests that neither better facilities, nor an increase in the amount of time allocated to PE to four hours a week, will improve physical activity levels in children as a whole and thereby impact on the rising tide of obesity.

16 Dec 2004

M.E. emerges from the wilderness

In 1955 medical literature first defined and described M.E., an illness that had probably been with us for hundreds of years. But with a wide range of symptoms, no diagnostic test and much misunderstanding about its cause, people with M.E. often had to struggle to manage the illness with little support from specialist services.

14 Dec 2004

Start today of human tests for a preventive vaccine against the respiratory disease SARS

Powerful research tools that speed up vaccine development have led to the start today of human tests for a preventive vaccine against the respiratory disease SARS. The disease killed hundreds of people around the world before it was brought under control in 2003 with aggressive conventional public health measures.

13 Dec 2004

Association between gastrointestinal disorders and sleep disturbances

Mayo Clinic researchers report in the current issue of Mayo Clinic Proceedings an association between gastrointestinal disorders and sleep disturbances. The association is important because these problems cause significant health issues including greater need for general medical and mental health treatment.

13 Dec 2004

Obesity rate among American workers of all ages grew from 20% to 29% over the past decade

The obesity rate among American workers of all ages grew from 20% to 29% over the past decade, leading to serious repercussions in the workplace and a demand for solutions, according to a new Pfizer Inc study published today in the Journal of Occupational and Environmental Medicine.

13 Dec 2004

A new study has found fatty liver disease in nearly one third of American adults in a large urban population sample

The prevalence of the disease varied significantly among ethnic groups. Hispanics had a higher prevalence than whites, while blacks had a lower prevalence than whites.

8 Dec 2004

Zarnestra, a farnesyl transferase inhibitor, can help treat high-risk myelodysplastic syndrome patients

An oral targeted therapy gentle enough to be used by patients in their 70s or 80s is showing benefit in treating high-risk myelodysplastic syndrome (MDS), a pre-leukemic disorder that can progress to acute myelogenous leukemia (AML), according to a study presented at the annual meeting of the American Society of Hematology (ASH).

7 Dec 2004

Babies who do not sleep on their stomachs fail to learn behaviors that may lessen their risk SIDS

Babies who never sleep on their stomachs don't learn behaviors that may lessen their risk of sudden infant death syndrome (SIDS), researchers at Washington University School of Medicine in St. Louis have found. Even so, the researchers caution that infants should always be placed on their backs to sleep.

6 Dec 2004

New insight into anticoagulation therapies

Anticoagulation therapies, or treatments that reduce the amount of clotting factors in the blood, are quite common and used for a variety of reasons.

6 Dec 2004

New advances in sickle cell disease

Excruciating pain episodes, recurrent pneumonias, strokes, severe infections, chronic hemolytic anemia, and secondary pulmonary hypertension are common complications of sickle cell disease, a life-threatening inherited defect in blood that causes normally disc-shaped red blood cells to take on a sickle shape.

6 Dec 2004

Cognitive behaviour therapy helps adolescents with chronic fatigue syndrome

Psychological support, in the form of cognitive behaviour therapy, is an effective treatment for adolescents with chronic fatigue syndrome, finds a new study published on bmj.com today.

6 Dec 2004

Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Modern research is delving deep into the human genome to find the answers to medical mysteries and, hopefully, cures for the most deadly diseases. According to four new studies presented during the 46th Annual Meeting of the American Society of Hematology

5 Dec 2004

Researchers step closer to cure for common childhood cancer

Acute lymphoblastic leukemia (ALL) is a malignant disease caused by the abnormal growth and development of white blood cells (WBC) in the bone marrow and blood. ALL is the most common cancer occurring in children with an annual rate of approximately 30 to 40 new cases per million.

5 Dec 2004

Positive results from phase 2 trial of Telintra, drug candidate in myelodysplastic syndrome

Telik, Inc. reported positive interim data from a Phase 2 trial of its Telintra (TLK199) drug candidate in myelodysplastic syndrome (MDS). The data were reported in two presentations at the annual meeting of the American Society of Hematology in San Diego.

5 Dec 2004

Syndrome News and Research

DLX5 gene may play a role in the pathology of Rett Syndrome

Tentative approval for Topiramate Tablets

Rett Syndrome, the first identified epigenetic disease - linked to specific defects in the three-dimensional folding of chromatin

The regulation of physical activity in young children

M.E. emerges from the wilderness

Start today of human tests for a preventive vaccine against the respiratory disease SARS

Association between gastrointestinal disorders and sleep disturbances

Obesity rate among American workers of all ages grew from 20% to 29% over the past decade

A new study has found fatty liver disease in nearly one third of American adults in a large urban population sample

Zarnestra, a farnesyl transferase inhibitor, can help treat high-risk myelodysplastic syndrome patients

Babies who do not sleep on their stomachs fail to learn behaviors that may lessen their risk SIDS

New insight into anticoagulation therapies

New advances in sickle cell disease

Cognitive behaviour therapy helps adolescents with chronic fatigue syndrome

Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Researchers step closer to cure for common childhood cancer

Positive results from phase 2 trial of Telintra, drug candidate in myelodysplastic syndrome

Oral targeted therapy shows benefit in treating high-risk myelodysplastic syndrome

Novel anti-obesity compound shows promise for treatment of obesity

Rimonabant could be safer for treating obesity than previous weight-loss drugs

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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