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Expression profiles and functional analyses of Wnt-related genes in human joint disorders

The cellular signaling protein Wnt, which is involved in embryonic development and cancer, contributes to disease progression of both rheumatoid arthritis and osteoarthritis.

26 Jun 2005

Researchers discover mechanism that causes a protein to clump together in brain cells of people with Parkinson's disease

The protein clumping is part of a "vicious cycle," the researchers said. As the proteins cluster, they inhibit an enzyme that normally breaks them down, leading to the formation of even more masses.

21 Jun 2005

Scientists identify inhibitors of the anthrax toxin

A collaborative team of scientists led by The Burnham Institute's Maurizio Pellecchia, Ph.D., has identified inhibitors of the anthrax toxin, termed lethal factor ("LF") that could be developed into an emergency treatment for exposure to inhalation anthrax.

21 Jun 2005

Rosetta Genomics identifies hundreds of novel human microRNAs

In a study published online this week and to be published as a cover story in the July issue of Nature Genetics, Rosetta Genomics' scientists report identification of hundreds of human microRNA genes, including the first report of primate specific microRNAs.

21 Jun 2005

Cyr61 gene transfer appears potent in stimulation of myocardial angiogenesis

French scientists, examining the possibility of using nuclear medicine with gene therapy to fight heart diseases, reported their findings at the Society of Nuclear Medicine's 52nd Annual Meeting June 18–22 in Toronto.

20 Jun 2005

Enzyme family plays role in Alzheimer's

The route to a treatment for Alzheimer's disease may have become more straightforward with the discovery that a key enzyme known to have a major role in this disease is in fact part of a family of enzymes. Only some family members play a role in the progression of this brain-wasting illness, new research at the University of Toronto has found.

20 Jun 2005

Fragile-X-syndrome research

The fragile-X-syndrome is the most common hereditary form of mental retardation and occurs much more often in boys than in girls.

20 Jun 2005

Elevated C-reactive protein can foil diet's ability to lower cholesterol

If you have high levels of C-reactive protein (CRP), a marker in blood for inflammation that is strongly associated with heart disease, trying to lower your LDL-cholesterol through modest diet changes alone may not work.

20 Jun 2005

Unique arrays of proteins tethered onto self-assembled DNA nanostructures

In the fifty-year history since the structure of DNA was first revealed, what was once a Nobel prize- winning research discovery has become an omnipresent cultural icon co-opted for promoting everything from fragrances to musical acts.

20 Jun 2005

Damage to DNA in sperm is significantly higher in older men

Damage to DNA in sperm is significantly higher in older men than in those who are younger, according to research presented today (Tuesday 21 June 2005) at the 21st annual conference of the European Society of Human Reproduction and Embryology.

20 Jun 2005

Studies show Alzheimer's prevented by drinking juice daily and having the occasional alcoholic drink

At a conference in the U.S. on Alzheimer's disease on June 19, researchers said that they think brain scans and simple blood tests may offer the best ways to predict who has the highest risk of Alzheimer's disease.

20 Jun 2005

First blood test to help predict a patient's risk for ischemic stroke

The U.S. Food and Drug Administration (FDA) has approved the first blood test designed to help predict a patient's risk for ischemic stroke, the most common type of stroke and one of the nation's leading causes of long-term disability affecting approximately 700,000 people per year.

19 Jun 2005

Most common form of lung cancer may begin in a group of newly isolated lung stem cells

Working in a mouse model, the researchers isolated a novel type of lung cell that can divide into fresh copies of itself and into the two more specialized kinds of cells deep in the lung.

16 Jun 2005

Findings may help scientists improve the existing vaccine for yellow fever

In one of the first molecular studies of the human antibody response to yellow fever, Howard Hughes Medical Institute (HHMI) researchers and their colleagues have found the crucial bit of virus that people's immune systems need to spot and quash this often-fatal re-emerging disease.

16 Jun 2005

Inactive gene may explain higher incidence of prostate cancer in African-Americans compared to Caucasians

Among African-Americans with prostate cancer, a tumor-suppressing gene called GSTP1 is inactivated at a rate 3.5 times higher than among Caucasians, according to a study conducted at the San Francisco VA Medical Center (SFVAMC).

16 Jun 2005

Scientists have tracked down the biological trigger that gives rise to Van Buchem disease

...a hereditary, disfiguring bone disorder that can cause blindness and deafness. The findings provide insight into long-range gene regulation and could lead to new treatments for osteoporosis and other crippling bone disorders.

16 Jun 2005

Pandemics such as Ebola, SARS, and avian influenza demands a more holistic approach to disease control

The threat of potential pandemics such as Ebola, SARS, and avian influenza demands a more holistic approach to disease control, one that prevents diseases from crossing the divide between humans, their livestock, and wildlife, according to the Wildlife Conservation Society (WCS) in the most recent issue of the journal Foreign Affairs.

16 Jun 2005

Hydroxyurea may prevent complications such as organ damage and stunted growth in treatment of sickle cell disease

Treating babies who have sickle cell disease (SCD) with oral liquid hydroxyurea appears to prevent the onset of long-term complications triggered by this disease, according to results of a preliminary study by investigators at St. Jude Children's Research Hospital.

16 Jun 2005

Wonder drug attacks range of cancers

A team of cancer research scientists from the Royal Marsden Hospital in London say the drug 17AAG has shown in early trials, promising signs of fighting a range of cancers.

16 Jun 2005

First demonstration of a vaccine for Parkinson's

Researchers at the University of California, San Diego (UCSD) School of Medicine working with scientists at Elan Pharmaceuticals, have reported promising results in mice of a vaccine approach to treating Parkinson’s and similar diseases. These results appear in the June edition of the journal Neuron.

15 Jun 2005

G Protein News and Research

Expression profiles and functional analyses of Wnt-related genes in human joint disorders

Researchers discover mechanism that causes a protein to clump together in brain cells of people with Parkinson's disease

Scientists identify inhibitors of the anthrax toxin

Rosetta Genomics identifies hundreds of novel human microRNAs

Cyr61 gene transfer appears potent in stimulation of myocardial angiogenesis

Enzyme family plays role in Alzheimer's

Fragile-X-syndrome research

Elevated C-reactive protein can foil diet's ability to lower cholesterol

Unique arrays of proteins tethered onto self-assembled DNA nanostructures

Damage to DNA in sperm is significantly higher in older men

Studies show Alzheimer's prevented by drinking juice daily and having the occasional alcoholic drink

First blood test to help predict a patient's risk for ischemic stroke

Most common form of lung cancer may begin in a group of newly isolated lung stem cells

Findings may help scientists improve the existing vaccine for yellow fever

Inactive gene may explain higher incidence of prostate cancer in African-Americans compared to Caucasians

Scientists have tracked down the biological trigger that gives rise to Van Buchem disease

Pandemics such as Ebola, SARS, and avian influenza demands a more holistic approach to disease control

Hydroxyurea may prevent complications such as organ damage and stunted growth in treatment of sickle cell disease

Wonder drug attacks range of cancers

First demonstration of a vaccine for Parkinson's

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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