G Protein News and Research

RSS

Link between PKC enzyme and kidney disease in diabetes confirmed

Researchers at Joslin Diabetes Center have investigated PKC-beta - a critical enzyme implicated in the devastating complications of type 1 and type 2 diabetes - for more than two decades.

12 Jun 2005

Poor diet during pregnancy increases risk of child being obese

It is common knowledge that a well balanced diet in pregnancy is crucial, but now scientists say they believe a poor diet during pregnancy appears to raise the chances of having an obese child.

12 Jun 2005

Link between hyperglycemia (high blood glucose), overexpression of PKC-beta 2 and kidney disease

Scientists at Joslin Diabetes Center have investigated PKC-beta -- a critical enzyme implicated in the devastating complications of type 1 and type 2 diabetes -- for more than two decades.

10 Jun 2005

If a dividing cell's activity is a pop song, then the same process in an immune cell is an extended-play dance remix

The basics of cell division are the same in both, but there's a heck of a lot more going on in immune cells, Johns Hopkins scientists have discovered.

10 Jun 2005

First clues as to why stem cells ignore stop signs in the cell cycle

Everyone knows that stem cells are controversial. Many people know that stem cells can grow into virtually any cell type found in the body, from a red blood cell to a muscle cell to a brain cell. But no one really knows why stem cells continue to divide and renew themselves long after the point where other cells stop dividing.

10 Jun 2005

DNA discovery may help explain disorders such as autism

Researchers have made a discovery that may in future help to explain many aspects of human social behavior and disorders such as autism.

10 Jun 2005

Researchers discover how hepatic-C virus evades immune system in acute and chronic infections

Researchers at Johns Hopkins have uncovered how a majority of the genetic changes in the hepatic-C virus, the most common cause of liver disease, allow it to evade the body's immune system during infection.

10 Jun 2005

Researchers explain how ubiquitin function is determined

University of Maryland researchers have explained, for the first time, why the linkage between the cell-regulating protein molecules called ubiquitins determines their function.

10 Jun 2005

Scientists produce for the first time an infectious form of the hepatitis C virus in laboratory cultures of human cells

The finding, reported in the June 9 issue of Science Express, will allow scientists to study every stage of the HCV life cycle and develop drugs to treat this life-threatening disease that affects more than 170 million people around the world.

9 Jun 2005

Molecule called Smad7 may open doors to future treatments in pancreatic and other forms of cancer

Making new strides in their ongoing effort to understand mechanisms behind the relentless growth of cancer cells, researchers at Dartmouth Medical School have found a promising key that may open doors to future treatments in pancreatic and other forms of cancer.

9 Jun 2005

Accumulation of genetic changes is not solely determined by natural selection

New data suggest that the accumulation of genetic changes is not solely determined by natural selection. A study by University of Chicago researchers contradicts conventional theory by showing that the percentage of mutations accepted in evolution is also strongly swayed by the speed at which new mutations arrive at a gene: the faster the speed of new mutations, the greater the percentage of those mutations accepted.

9 Jun 2005

Study of glial cells in the roundworm C. elegans may provide insight into a variety of human brain diseases

The key to understanding our brains may lie within a one-millimeter long worm, new research from Rockefeller University indicates. Reporting in the June issue of Developmental Cell, Shai Shaham, Ph.D., and graduate student Elliot Perens use the roundworm, C. elegans, to investigate the mysterious glial cell, which makes up 90 percent of the human brain and, when it malfunctions, can contribute to diseases like Parkinson's disease and schizophrenia.

9 Jun 2005

Exposing SMA-affected cells to aminoglycoside drugs can increase SMN

MDA grantee Christian Lorson at the University of Missouri was on a team that found that exposing cells carrying a mutation that causes spinal muscular atrophy (SMA) to drugs in the aminoglycoside family helps them produce more of the needed SMN protein, a lack of which leads to SMA.

9 Jun 2005

Research opens up new directions for studying prion diseases in humans

The mysterious, highly infectious prions, which cause the severe destruction of the brain that characterizes "mad cow disease" and several human brain degenerative disorders, can be rendered harmless in the laboratory by a slight alternation of the three-dimensional conformation or shape of the prion protein's structure.

9 Jun 2005

Fundamental insights in how amyloid fibers form

Amyloid fibers are best known as the plaque that gunks up neurons in people with neurodegenerative illnesses such as Alzheimer's and Creutzfeldt-Jacob disease--the human analog of mad cow disease.

9 Jun 2005

Discovery of molecular mechanism that seems to play an important role in Alzheimer's disease

An international team of chemists and molecular biologists has discovered a fundamental molecular mechanism that seems to play an important role in Alzheimer's disease, Parkinson's disease, mad cow disease and two-dozen other degenerative and fatal diseases.

8 Jun 2005

New understanding of microRNAs

Ribonucleic acid, or RNA, has long been thought to be important only to translate a gene's DNA into the proteins that are cells' workhorses. But new evidence shows that tiny bits of RNA not used to make proteins actually play central roles in normal biology and in the development of cancers.

8 Jun 2005

Prototype drug shows promise in slowing replication of the virus responsible for SARS

A prototype drug created by researchers at the University of Illinois at Chicago shows promise in slowing replication of the virus responsible for severe acute respiratory syndrome, or SARS.

8 Jun 2005

Novel targets found for the development of drugs to complement, or replace, statins

A team of investigators from the Uppsala Branch of the Ludwig Institute for Cancer Research (LICR) and Harvard Medical School has uncovered novel targets for the development of drugs that would potentially complement, or replace, statins in treating heart disease.

8 Jun 2005

New device has the potential to significantly reduce sequencing of the human genome

The sequencing of the human genome was only the beginning of a much more complex task – deciphering the secrets of cellular chemistry and the mechanisms of disease. While the genome serves as a blueprint to understanding the body, proteins represent the materials that carry out these plans.

8 Jun 2005

G Protein News and Research

Link between PKC enzyme and kidney disease in diabetes confirmed

Poor diet during pregnancy increases risk of child being obese

Link between hyperglycemia (high blood glucose), overexpression of PKC-beta 2 and kidney disease

If a dividing cell's activity is a pop song, then the same process in an immune cell is an extended-play dance remix

First clues as to why stem cells ignore stop signs in the cell cycle

DNA discovery may help explain disorders such as autism

Researchers discover how hepatic-C virus evades immune system in acute and chronic infections

Researchers explain how ubiquitin function is determined

Scientists produce for the first time an infectious form of the hepatitis C virus in laboratory cultures of human cells

Molecule called Smad7 may open doors to future treatments in pancreatic and other forms of cancer

Accumulation of genetic changes is not solely determined by natural selection

Study of glial cells in the roundworm C. elegans may provide insight into a variety of human brain diseases

Exposing SMA-affected cells to aminoglycoside drugs can increase SMN

Research opens up new directions for studying prion diseases in humans

Fundamental insights in how amyloid fibers form

Discovery of molecular mechanism that seems to play an important role in Alzheimer's disease

New understanding of microRNAs

Prototype drug shows promise in slowing replication of the virus responsible for SARS

Novel targets found for the development of drugs to complement, or replace, statins

New device has the potential to significantly reduce sequencing of the human genome

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Applications Engineer

Latest News