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Antibody that neutralizes most HIV strains

A group of scientists from The Scripps Research Institute and several other institutions has solved the structure of a rare human antibody that broadly neutralizes human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS).

22 Feb 2005

Researchers have identified a protein called HIF-2a, which is important in retina formation

Hoping to prevent blindness in premature babies, UT Southwestern Medical Center researchers have identified a protein that responds to oxygen levels in cells and tissues and also affects the developing eye.

22 Feb 2005

Lack of magnesium in diet linked to disease

The Gordon Research International Conference on Magnesium was held during the second week in February in Ventura, California, to discuss the research findings on the links between deficiencies in the mineral magnesium and a host of life-threatening diseases, including heart disease and arteriosclerosis.

22 Feb 2005

Dietary protein and bone health revisited

Agricultural Research Service (ARS) scientists first compared high-meat protein diets with low-meat protein diets. Now, they've compared animal-protein diets with vegetable-protein diets. This "sequel" study rocks the foundation, again, of a commonly held belief that high-protein diets can be bad for bones.

22 Feb 2005

Differing forms of taste genes mean that we all live in our own unique taste world

A study published in the February 22 issue of Current Biology confirms the influential role of genetics in determining the wide range of human sensitivity to taste, ultimately impacting how we each perceive the world in a slightly different way.

22 Feb 2005

Secreted signaling protein called Wnt10b secret to new drugs for preventing or treating osteoporosis

Leaping tall buildings in a single bound may be out of the question, but the genetically engineered "supermice" in Ormond MacDougald's laboratory at the University of Michigan Medical School are definitely stronger than average.

22 Feb 2005

Diagnosis of prions in patients should utilize novel strategy, conformation-dependent immunoassay

A technique for detecting prions in tissue, developed in recent years by UCSF scientists, is significantly more sensitive than the diagnostic procedures currently used to detect the lethal particles in samples of brain tissue from patients, according to a study performed by a UCSF team.

22 Feb 2005

Why some lung cancers stop responding to the drugs erlotinib (Tarceva) and gefitinib (Iressa)

Researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) have found an explanation for why some lung cancers stop responding to the drugs erlotinib (Tarceva) and gefitinib (Iressa).

22 Feb 2005

New compound, AMN107, 20 times more potent than Gleevec for chronic myelogenous leukemia treatment

A laboratory study led by researchers at Dana-Farber Cancer Institute has shown that a potent and highly selective therapy for chronic myelogenous leukemia (CML) may ultimately be more effective than Gleevec®, the current standard of care.

21 Feb 2005

New clues to amyloidoses

Familial amyloid polyneuropathy (FAP), a hereditary disease characterised by abnormal deposits of insoluble protein in the organs, results from a mutation in a single gene (the transthyretin or TTR gene). Nevertheless, disease incidence and age of onset can vary significantly between patients what have always puzzled scientists.

21 Feb 2005

New findings on the regulation of cellular growth

A greatly increased synthesis of new proteins is one of the first and most important events that occur in both normal and tumour cells upon growth stimulation.

21 Feb 2005

Lack of collagen increases likelihood of osteoarthritis

Duke University Medical Center researchers have found that joints whose cartilage lacks a specific type of collagen will develop osteoarthritis – the so-called "wear-and-tear" form of the disease – at a greatly accelerated rate.

20 Feb 2005

Vaccine that boosts the immune response could improve the effect of conventional treatment for patients with chronic myeloid leukaemia

CML is caused by the breakage and swapping of chromosomes 9 and 22, which results in a shortened chromosome called the Philadelphia chromosome. Cells with the abnormal chromosome make a protein that encourages aberrant growth and division. Patients with CML can be treated with a drug called imatinib or interferon alfa.

20 Feb 2005

Shedding new LIGHT on disease

New drugs for the 270,000 people who suffer heart attacks every year in the UK will be among the projects in Leeds' new research institute. The Leeds Institute of Genetics Health and Therapeutics (LIGHT) was opened by head of the Medical Research Council chief executive Professor Colin Blakemore yesterday.

17 Feb 2005

Studies reveal methods viruses use to sidestep immune system

A series of studies by researchers at UT Southwestern Medical Center sheds light on the mechanisms used by viruses to thwart a host's immune defenses and may aid in the development of more effective drugs to fight hepatitis C and West Nile viruses, as well as the flu and the common cold.

17 Feb 2005

GenoMed files gene patents

GenoMed has filed a patent application on two additional genes linked to common cancers. These genes are the third and fourth identified as a result of GenoMed's research in 2005 to date. They have the potential to improve the outcomes for those individuals afflicted with these cancers.

16 Feb 2005

Young blood revives aging muscles

Any older person can attest that aging muscles don't heal like young ones. But it turns out that's not the muscle's fault. A study in the Feb. 17 issue of Nature shows that it's old blood that keeps the muscles down.

16 Feb 2005

Single gene variant may increase a man's risk of prostate cancer by 50%

In 2001, Mount Sinai researchers published a study in Science that showed that a gene, known as KLF6, fails to function properly in at least 50 to 60 percent of all prostate cancers. This was the first single gene shown to be responsible for the majority of cases of this disease, which affects approximately 200,000 men each year.

16 Feb 2005

Protein may provide a powerful new therapeutic tool for fighting kidney failure

Kidney failure is a significant risk for patients undergoing cardiopulmonary bypass surgery, radiologic testing, antibiotic therapy or in patients suffering from severe infections. More than 80 percent of patients with postoperative acute renal failure die.

16 Feb 2005

Antigens produced by the Epstein Barr virus may provide an ideal target for cancer therapy

A typically innocuous virus found in 90 percent of people worldwide is the key to a new treatment for a cancer particularly common in North Africa and Southeast Asia.

16 Feb 2005

G Protein News and Research

Antibody that neutralizes most HIV strains

Researchers have identified a protein called HIF-2a, which is important in retina formation

Lack of magnesium in diet linked to disease

Dietary protein and bone health revisited

Differing forms of taste genes mean that we all live in our own unique taste world

Secreted signaling protein called Wnt10b secret to new drugs for preventing or treating osteoporosis

Diagnosis of prions in patients should utilize novel strategy, conformation-dependent immunoassay

Why some lung cancers stop responding to the drugs erlotinib (Tarceva) and gefitinib (Iressa)

New compound, AMN107, 20 times more potent than Gleevec for chronic myelogenous leukemia treatment

New clues to amyloidoses

New findings on the regulation of cellular growth

Lack of collagen increases likelihood of osteoarthritis

Vaccine that boosts the immune response could improve the effect of conventional treatment for patients with chronic myeloid leukaemia

Shedding new LIGHT on disease

Studies reveal methods viruses use to sidestep immune system

GenoMed files gene patents

Young blood revives aging muscles

Single gene variant may increase a man's risk of prostate cancer by 50%

Protein may provide a powerful new therapeutic tool for fighting kidney failure

Antigens produced by the Epstein Barr virus may provide an ideal target for cancer therapy

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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